Difference between revisions of "Team:XJTLU-CHINA"

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         <title>XJTLU-CHINA 2017</title>
 
         <title>XJTLU-CHINA 2017</title>
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     <!-- Slider
 
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     ================================================== -->
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     <div class="center-block">
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     <div class="cd-slider-wrapper">
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    <div id="myCarousel" class="carousel slide" data-ride="carousel">
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    <h2>S. aureus Intestinal Colonization</h2>
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<p>Human intestine is a highly complex microbial ecosystem. It accommodates commensal microflora species, various types of secretory fluids, fermentation metabolites and host defense molecules that promote colonization resistance to pathogenic bacteria. However, Staphylococcus aureus, one of the most opportunistic and invasive pathogens, is capable of disrupting this colonization resistance and infecting the intestine. Patients with S. aureus intestinal colonization suffer from fecal incontinence, diarrhea, pseudomembranous colitis and so on.</p>
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      <div class="carousel-inner" role="listbox">
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<p><a class="btn btn-lg btn-primary" href="#" role="button">Learn more</a></p>
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        <!-- First slide -->
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        <div class="item active">
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          <img class="first-slide" src="https://static.igem.org/mediawiki/2017/8/8c/Home-1.png" alt="First slide">
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          <div class="container">
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            <div class="carousel-caption">
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<!-- Second slide -->
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              <h1>S. aureus Intestinal Colonization</h1>
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<li>
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              <p>Human intestine is a highly complex microbial ecosystem. It accommodates commensal microflora species, various types of secretory fluids, fermentation metabolites and host defense molecules that promote colonization resistance to pathogenic bacteria. However, Staphylococcus aureus, one of the most opportunistic and invasive pathogens, is capable of disrupting this colonization resistance and infecting the intestine. Patients with S. aureus intestinal colonization suffer from fecal incontinence, diarrhea, pseudomembranous colitis and so on.</p>
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<div class="cd-half-block image"></div>
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              <p><a class="btn btn-lg btn-primary" href="#" role="button">Learn more</a></p>
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            </div>
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        <!-- Second slide -->
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        <div class="item">
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          <img class="second-slide" src="https://static.igem.org/mediawiki/2017/3/37/Home-2.png" alt="Second slide">
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          <div class="container">
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            <div class="carousel-caption">
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              <h1>Antibiotic Overuse and Superbacteria</h1>
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              <p>Due to antibiotic overuse, Staphylococcus aureus develops resistance to various antibiotics and it becomes increasingly difficult to be eliminated. As a leading cause of hospital-acquired infections, methicillin-resistant S. aureus (MRSA) strains are multi-antibiotic resistant. Even the use of vancomycin — one of the last therapeutic resorts against S. aureus, becomes futile. Worse still, community-acquired MRSA strains are much more virulent and cause more morbidity and mortality than hospital-acquired MRSA.</p>
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              <p><a class="btn btn-lg btn-primary" href="#" role="button">Learn more</a></p>
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            </div>
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          </div>
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        <!-- Third slide -->
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        <div class="item">
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          <img class="third-slide" src="https://static.igem.org/mediawiki/2017/b/b5/Home-3.png" alt="Third slide">
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          <div class="container">
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            <div class="carousel-caption">
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              <h1>Antimicrobial Peptides — A Promising Alternative To Antibiotics.</h1>
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              <p>Antimicrobial peptides (AMPs) have a reputation for their efficient antimicrobial activity against bacteria, fungi and protozoa. Despite of some promising results in clinical trials, AMPs have difficulties to be made into drugs due to their poor metabolic stability in human body. Therefore, our project aims to genetically engineer Lactococcus lactis (Grenadier Guards) to closely detect S. aureus and throw AMPs (grenades) to eradicate them within a short time after infection.</p>
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              <p><a class="btn btn-lg btn-primary" href="#" role="button">Learn more</a></p>
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            </div>
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        <!-- Fourth slide -->
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          <img class="fourth-slide" src="https://static.igem.org/mediawiki/2017/5/55/Home-4.png" alt="Fourth slide">
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          <div class="container">
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            <div class="carousel-caption">
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              <h1>Further Applications</h1>
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              <p>Our genetically engineered Lactococcus lactis can be made into medicines, such as enteric coated tablets, together with anti-diarrheal medicines, to cure enteritis. In addition, as an important industrial microorganism, L. lactis can be used as food additives in fermented dairy products such as cheese, and yogurt. When they inhabit in the intestinal tract, not only do they regulate micro-ecological balance, but also prevent or reduce the chance of infection.</p>
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              <p><a class="btn btn-lg btn-primary" href="#" role="button">Learn more</a></p>
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        <span class="sr-only">Next</span>
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    </div><!-- /.carousel -->
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<div class="cd-half-block content light-bg">
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<div>
 +
<h2>Antibiotic Overuse and Superbacteria</h2>
 +
<p>Due to antibiotic overuse, Staphylococcus aureus develops resistance to various antibiotics and it becomes increasingly difficult to be eliminated. As a leading cause of hospital-acquired infections, methicillin-resistant S. aureus (MRSA) strains are multi-antibiotic resistant. Even the use of vancomycin — one of the last therapeutic resorts against S. aureus, becomes futile. Worse still, community-acquired MRSA strains are much more virulent and cause more morbidity and mortality than hospital-acquired MRSA.</p>
 +
<p><a class="btn btn-lg btn-primary" href="#" role="button">Learn more</a></p>
 +
</div>
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</div>
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</li> <!-- .cd-half-block.content -->
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<!-- Third slide -->
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<li>
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<div class="cd-half-block image"></div>
  
 +
<div class="cd-half-block content light-bg">
 +
<div>
 +
<h2>Antimicrobial Peptides — A Promising Alternative To Antibiotics</h2>
 +
<p>Antimicrobial peptides (AMPs) have a reputation for their efficient antimicrobial activity against bacteria, fungi and protozoa. Despite of some promising results in clinical trials, AMPs have difficulties to be made into drugs due to their poor metabolic stability in human body. Therefore, our project aims to genetically engineer Lactococcus lactis (Grenadier Guards) to closely detect S. aureus and throw AMPs (grenades) to eradicate them within a short time after infection.</p>
 +
<p><a class="btn btn-lg btn-primary" href="#" role="button">Learn more</a></p>
 +
</div>
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</div>
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</li> <!-- .cd-half-block.content -->
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<!-- Fourth slide -->
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<li>
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<div class="cd-half-block image"></div>
  
 +
<div class="cd-half-block content light-bg">
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<div>
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<h2>Further Applications</h2>
 +
<p>Our genetically engineered Lactococcus lactis can be made into medicines, such as enteric coated tablets, together with anti-diarrheal medicines, to cure enteritis. In addition, as an important industrial microorganism, L. lactis can be used as food additives in fermented dairy products such as cheese, and yogurt. When they inhabit in the intestinal tract, not only do they regulate micro-ecological balance, but also prevent or reduce the chance of infection.</p>
 +
                    <p><a class="btn btn-lg btn-primary" href="#" role="button">Learn more</a></p>
 +
</div>
 +
</div>
 +
</li> <!-- .cd-half-block.content -->
 +
</ul> <!-- .cd-slider -->
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</div> <!-- .cd-slider-wrapper -->
  
 
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     </body>
 
</html>
 
</html>

Revision as of 02:40, 2 August 2017

XJTLU-CHINA 2017

Overview

  • S. aureus Intestinal Colonization

    Human intestine is a highly complex microbial ecosystem. It accommodates commensal microflora species, various types of secretory fluids, fermentation metabolites and host defense molecules that promote colonization resistance to pathogenic bacteria. However, Staphylococcus aureus, one of the most opportunistic and invasive pathogens, is capable of disrupting this colonization resistance and infecting the intestine. Patients with S. aureus intestinal colonization suffer from fecal incontinence, diarrhea, pseudomembranous colitis and so on.

    Learn more

  • Antibiotic Overuse and Superbacteria

    Due to antibiotic overuse, Staphylococcus aureus develops resistance to various antibiotics and it becomes increasingly difficult to be eliminated. As a leading cause of hospital-acquired infections, methicillin-resistant S. aureus (MRSA) strains are multi-antibiotic resistant. Even the use of vancomycin — one of the last therapeutic resorts against S. aureus, becomes futile. Worse still, community-acquired MRSA strains are much more virulent and cause more morbidity and mortality than hospital-acquired MRSA.

    Learn more

  • Antimicrobial Peptides — A Promising Alternative To Antibiotics

    Antimicrobial peptides (AMPs) have a reputation for their efficient antimicrobial activity against bacteria, fungi and protozoa. Despite of some promising results in clinical trials, AMPs have difficulties to be made into drugs due to their poor metabolic stability in human body. Therefore, our project aims to genetically engineer Lactococcus lactis (Grenadier Guards) to closely detect S. aureus and throw AMPs (grenades) to eradicate them within a short time after infection.

    Learn more

  • Further Applications

    Our genetically engineered Lactococcus lactis can be made into medicines, such as enteric coated tablets, together with anti-diarrheal medicines, to cure enteritis. In addition, as an important industrial microorganism, L. lactis can be used as food additives in fermented dairy products such as cheese, and yogurt. When they inhabit in the intestinal tract, not only do they regulate micro-ecological balance, but also prevent or reduce the chance of infection.

    Learn more