Difference between revisions of "Team:BGIC-Union"

m
Line 10: Line 10:
  
 
   <head>
 
   <head>
 +
 
 +
        <link href='http://fonts.googleapis.com/css?family=Lato:400,300' rel='stylesheet' type='text/css'>
 +
        <link href='http://fonts.googleapis.com/css?family=Raleway:400,300,500' rel='stylesheet' type='text/css'>
 +
 
   <!-- Bootstrap core CSS -->
 
   <!-- Bootstrap core CSS -->
 
     <link href="https://2017.igem.org/Template:BGIC-Union/bootstrap-css?action=raw&amp;ctype=text/css" rel="stylesheet">
 
     <link href="https://2017.igem.org/Template:BGIC-Union/bootstrap-css?action=raw&amp;ctype=text/css" rel="stylesheet">
Line 16: Line 20:
 
   <!-- carousel -->
 
   <!-- carousel -->
 
   <link href="https://2017.igem.org/Template:BGIC-Union/owlcarousel-css?action=raw&amp;ctype=text/css" rel="stylesheet">
 
   <link href="https://2017.igem.org/Template:BGIC-Union/owlcarousel-css?action=raw&amp;ctype=text/css" rel="stylesheet">
−
   <link href=" https://2017.igem.org/Template:BGIC-Union/fontawesomemin-css?action=raw&amp;ctype=text/css" rel="stylesheet">
+
   <link href=" https://2017.igem.org/Template:BGIC-Union/fontawesomemin2-css?action=raw&amp;ctype=text/css" rel="stylesheet">
−
    
+
   <!-- light -->
 +
<style type="text/css">
 +
/* fixed line holder */
 +
.timelineLight .timeline_line {c
 +
margin-top:10px;
 +
margin-bottom:10px;
 +
width:900px;
 +
}
 +
 
 +
/* full (including months that are not shown) line holder */
 +
.timelineLight .t_line_holder {
 +
height:80px;
 +
background:url('https://static.igem.org/mediawiki/2017/3/35/Line.jpg') repeat-x 0px 39px;
 +
}
 +
 
 +
/* 2 months are stored in one view */
 +
.timelineLight .t_line_view {
 +
height:20px;
 +
width:900px;
 +
}
 +
 
 +
/* holder for year number */
 +
.timelineLight h3.t_line_year {
 +
margin:0;
 +
color:#545454;
 +
}
 +
 
 +
/* holder for 1 month (constist of nodes and month caption) - we use borders to separate months thats why it has width 2px less then 50% */
 +
.timelineLight .t_line_m {
 +
margin-top:35px;
 +
height:10px;
 +
border-left:1px solid #545454;
 +
border-right:1px solid #545454;
 +
width:448px;
 +
}
 +
 
 +
/* month on the right side - has left set at 459 so border would overlap border from first element (to evade duplicated borders) */
 +
.timelineLight .t_line_m.right {
 +
left:449px;
 +
width:449px;
 +
}
 +
 
 +
/* month caption */
 +
.timelineLight h4.t_line_month {
 +
margin:-30px 0 0;
 +
color:#545454;
 +
}
 +
 
 +
/* used in responsive layout when only one month is shown (it is span containing year) */
 +
.t_line_month_year {
 +
display:none;
 +
}
 +
 
 +
/* node on the timeline */
 +
.timelineLight a.t_line_node {
 +
text-decoration:none;
 +
padding:38px 0 4px;
 +
height:10px;
 +
font-size:12px;
 +
top:-25px;
 +
background:url('https://static.igem.org/mediawiki/2017/2/2a/Dot.png') no-repeat center 24px;
 +
color:#141817;
 +
}
 +
.timelineLight a.t_line_node:hover {
 +
background:url('https://static.igem.org/mediawiki/2017/6/65/Dot-rollover.png') no-repeat center 24px;
 +
}
 +
.timelineLight a.t_line_node.active {
 +
background:url('https://static.igem.org/mediawiki/2017/d/d7/Dot-selected.png') no-repeat center 24px;
 +
}
 +
 
 +
/* node description */
 +
.timelineLight .t_node_desc {
 +
background: rgba(26,134,172,0.9);
 +
top:0;
 +
color:#fff;
 +
padding:1px 5px;
 +
}
 +
 
 +
/* descriptions on right side go from right to left */
 +
.timelineLight .t_node_desc.pos_right {
 +
right:0;
 +
}
 +
 
 +
/* line arrow left */
 +
.timelineLight #t_line_left {
 +
cursor:pointer;
 +
left:-30px;
 +
top:30px;
 +
width:14px;
 +
height:19px;
 +
background:url('https://static.igem.org/mediawiki/2017/9/95/Bgic-arrow.png') no-repeat left top;
 +
}
 +
 
 +
.timelineLight #t_line_left:hover {
 +
background:url('https://static.igem.org/mediawiki/2017/9/95/Bgic-arrow.png') no-repeat left bottom;
 +
}
 +
 
 +
/* line arrow right */
 +
.timelineLight #t_line_right {
 +
cursor:pointer;
 +
right:-30px;
 +
top:30px;
 +
width:14px;
 +
height:19px;
 +
background:url('https://static.igem.org/mediawiki/2017/9/95/Bgic-arrow.png') no-repeat right top;
 +
}
 +
 
 +
.timelineLight #t_line_right:hover {
 +
background:url('https://static.igem.org/mediawiki/2017/9/95/Bgic-arrow.png') no-repeat right bottom;
 +
}
 +
.timelineLight {
 +
display:none;
 +
}
 +
 
 +
/* items container */
 +
.timelineLight .timeline_items {
 +
padding:10px 0;
 +
}
 +
 
 +
/* single item (margines set from javascript) */
 +
.timelineLight .item {
 +
height:380px;
 +
text-align:center;
 +
background:url('../images/timeline/light/background-white.jpg') repeat;
 +
color:#545454;
 +
-moz-box-shadow: -3px 1px 6px rgba(0,0,0,0.4);
 +
-webkit-box-shadow: -3px 1px 6px rgba(0,0,0,0.4);
 +
box-shadow: -3px 1px 6px rgba(0,0,0,0.4);
 +
width:200px;
 +
}
 +
 
 +
/* ----- content - non-plugin elements ----- */
 +
.timelineLight .item img {
 +
margin-top:0;
 +
width:200px;
 +
}
 +
 
 +
.timelineLight .item span{
 +
display:block;
 +
margin:0px 20px 10px;
 +
height:150px;
 +
}
 +
.timelineLight .item .read_more {
 +
padding:2px 8px 2px 10px;
 +
font-family: 'BebasNeueRegular';
 +
font-size:20px;
 +
float:right;
 +
color:#ffffff;
 +
background: rgba(0,0,0,0.35);
 +
cursor:pointer;
 +
}
 +
.timelineLight .item .read_more:hover {
 +
background:rgb(26,134,172);
 +
}
 +
/* ----------------------------------------- */
 +
 
 +
/* item details (margines set from javascript) */
 +
.timelineLight .item_open {
 +
height:380px;
 +
background:url('../images/timeline/light/background.jpg') repeat;
 +
position:relative;
 +
color:#545454;
 +
z-index:2;
 +
-moz-box-shadow: 0px 0px 6px rgba(0,0,0,0.4);
 +
-webkit-box-shadow: 0px 0px 6px rgba(0,0,0,0.4);
 +
box-shadow: 0px 0px 6px rgba(0,0,0,0.4);
 +
width:490px;
 +
 +
}
 +
 
 +
/* item details content wrapper (used for animation - shuld have same width as .item_open) */
 +
.timelineLight .item_open_cwrapper {
 +
width:490px;
 +
}
 +
 
 +
/* ----- content - non-plugin elements ----- */
 +
.timelineLight .timeline_open_content {
 +
padding:20px;
 +
}
 +
 
 +
.timelineLight .item_open h2 {
 +
margin-top:10px;
 +
padding-top:0;
 +
font-size:28px;
 +
}
 +
.timelineLight .item_open .t_close {
 +
position:absolute;
 +
top:10px;
 +
right:10px;
 +
padding:2px 8px 2px 10px;
 +
font-family: 'BebasNeueRegular';
 +
font-size:20px;
 +
color:#ffffff;
 +
background: rgba(0,0,0,0.25);
 +
cursor:pointer;
 +
}
 +
.timelineLight .item_open .t_close:hover {
 +
background:rgb(26,134,172);
 +
}
 +
/* ----------------------------------------- */
 +
 
 +
/* left/right controles */
 +
.timelineLight .t_controles {
 +
margin:10px auto;
 +
text-align:center;
 +
}
 +
.timelineLight .t_left,
 +
.timelineLight .t_right {
 +
display:inline-block;
 +
height:50px;
 +
width:29px;
 +
margin:10px;
 +
cursor:pointer;
 +
}
 +
.timelineLight .t_left, 
 +
.timelineLight .t_left:hover:active {
 +
background: url('https://static.igem.org/mediawiki/2017/b/ba/Big-arrow.png') no-repeat left top;
 +
}
 +
.timelineLight .t_left:hover {
 +
background: url('https://static.igem.org/mediawiki/2017/b/ba/Big-arrow.png') no-repeat left bottom;
 +
}
 +
 
 +
.timelineLight .t_right,
 +
.timelineLight .t_right:hover:active{
 +
background: url('https://static.igem.org/mediawiki/2017/b/ba/Big-arrow.png') no-repeat right top;
 +
}
 +
 
 +
.timelineLight .t_right:hover {
 +
background: url('https://static.igem.org/mediawiki/2017/b/ba/Big-arrow.png') no-repeat right bottom;
 +
}
 +
 
 +
/* -----------------------------------------------------------------------*/
 +
/* ------------------------------ RESPONSIVE -----------------------------*/
 +
/* -----------------------------------------------------------------------*/
 +
 
 +
 
 +
 
 +
/* --- 768px --- */
 +
@media screen and (max-width:980px) {
 +
 +
.timelineLight .timeline_line {
 +
width:680px;
 +
}
 +
 +
.timelineLight .t_line_view {
 +
width:680px;
 +
}
 +
 +
.timelineLight .t_line_m {
 +
width: 338px;
 +
}
 +
.timelineLight .t_line_m.right {
 +
left: 339px;
 +
width: 339px;
 +
}
 +
}
 +
 
 +
 
 +
/* --- 610px --- */
 +
@media screen and (max-width:767px) {
 +
 +
.timelineLight .timeline_line {
 +
width:530px;
 +
}
 +
 +
.timelineLight .t_line_view {
 +
width:1060px;
 +
}
 +
 +
.timelineLight .t_line_m {
 +
width: 528px;
 +
}
 +
.timelineLight .t_line_m.right {
 +
left: 530px;
 +
width: 528px;
 +
}
 +
.timelineLight .t_line_year {
 +
opacity:0;
 +
filter:alpha(opacity=0)
 +
}
 +
.timelineLight .t_line_month_year {
 +
display:inline;
 +
}
 +
 +
.timelineLight .t_line_node span {
 +
 +
}
 +
.timelineLight .t_node_desc {
 +
font-size:8px;
 +
}
 +
.timelineLight .t_node_desc.pos_right {
 +
right:auto;
 +
left:0;
 +
}
 +
}
 +
 
 +
 
 +
/* --- 300px --- */
 +
@media screen and (max-width:
 +
 
 +
) {
 +
.timelineLight .timeline_line {
 +
width:240px;
 +
}
 +
 +
.timelineLight .t_line_view {
 +
width:480px;
 +
}
 +
 +
.timelineLight .t_line_m {
 +
width: 238px;
 +
}
 +
.timelineLight .t_line_m.right {
 +
left: 240px;
 +
width: 238px;
 +
}
 +
 +
.timelineLight .item_open {
 +
width:280px;
 +
height:390px;
 +
}
 +
.timelineLight .item_open_cwrapper {
 +
width:280px;
 +
}
 +
}
 +
 
 +
 
 +
 
 +
 
 +
</style>
 +
 
 
   <!-- main -->
 
   <!-- main -->
 
   <style type="text/css">
 
   <style type="text/css">
Line 253: Line 587:
 
     position:relative;  
 
     position:relative;  
 
     overflow:hidden;  
 
     overflow:hidden;  
−
     background:transparent url(../img/loader.gif) no-repeat center;
+
     background:transparent url(https://static.igem.org/mediawiki/2017/f/fe/Bgic_loader.gif) no-repeat center;
 
}
 
}
  
Line 284: Line 618:
 
   <!-- slider -->
 
   <!-- slider -->
 
   <style type="text/css">
 
   <style type="text/css">
 +
 
   /* Section Slider
 
   /* Section Slider
 
========================================================= */
 
========================================================= */
Line 290: Line 625:
 
============================================== */
 
============================================== */
 
#slider_part {
 
#slider_part {
−
     height: 800px;
+
     height: 900px;
 
     width: 100%;
 
     width: 100%;
 
     overflow: hidden;
 
     overflow: hidden;
 +
background-color: #f2f2f2;
 
}
 
}
  
Line 480: Line 816:
 
   <!-- script -->
 
   <!-- script -->
 
   <script src="https://code.jquery.com/jquery-1.10.2.min.js"></script>
 
   <script src="https://code.jquery.com/jquery-1.10.2.min.js"></script>
 +
  <script type="text/javascript">
 +
  /*
 +
* jQuery Easing v1.3 - http://gsgd.co.uk/sandbox/jquery/easing/
 +
*
 +
* Uses the built in easing capabilities added In jQuery 1.1
 +
* to offer multiple easing options
 +
*
 +
* TERMS OF USE - jQuery Easing
 +
*
 +
* Open source under the BSD License.
 +
*
 +
* Copyright © 2008 George McGinley Smith
 +
* All rights reserved.
 +
*
 +
* Redistribution and use in source and binary forms, with or without modification,
 +
* are permitted provided that the following conditions are met:
 +
*
 +
* Redistributions of source code must retain the above copyright notice, this list of
 +
* conditions and the following disclaimer.
 +
* Redistributions in binary form must reproduce the above copyright notice, this list
 +
* of conditions and the following disclaimer in the documentation and/or other materials
 +
* provided with the distribution.
 +
*
 +
* Neither the name of the author nor the names of contributors may be used to endorse
 +
* or promote products derived from this software without specific prior written permission.
 +
*
 +
* THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND ANY
 +
* EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF
 +
* MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE
 +
*  COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL,
 +
*  EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE
 +
*  GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED
 +
* AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING
 +
*  NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED
 +
* OF THE POSSIBILITY OF SUCH DAMAGE.
 +
*
 +
*/
 +
 +
// t: current time, b: begInnIng value, c: change In value, d: duration
 +
jQuery.easing['jswing'] = jQuery.easing['swing'];
 +
 +
jQuery.extend( jQuery.easing,
 +
{
 +
def: 'easeOutQuad',
 +
swing: function (x, t, b, c, d) {
 +
//alert(jQuery.easing.default);
 +
return jQuery.easing[jQuery.easing.def](x, t, b, c, d);
 +
},
 +
easeInQuad: function (x, t, b, c, d) {
 +
return c*(t/=d)*t + b;
 +
},
 +
easeOutQuad: function (x, t, b, c, d) {
 +
return -c *(t/=d)*(t-2) + b;
 +
},
 +
easeInOutQuad: function (x, t, b, c, d) {
 +
if ((t/=d/2) < 1) return c/2*t*t + b;
 +
return -c/2 * ((--t)*(t-2) - 1) + b;
 +
},
 +
easeInCubic: function (x, t, b, c, d) {
 +
return c*(t/=d)*t*t + b;
 +
},
 +
easeOutCubic: function (x, t, b, c, d) {
 +
return c*((t=t/d-1)*t*t + 1) + b;
 +
},
 +
easeInOutCubic: function (x, t, b, c, d) {
 +
if ((t/=d/2) < 1) return c/2*t*t*t + b;
 +
return c/2*((t-=2)*t*t + 2) + b;
 +
},
 +
easeInQuart: function (x, t, b, c, d) {
 +
return c*(t/=d)*t*t*t + b;
 +
},
 +
easeOutQuart: function (x, t, b, c, d) {
 +
return -c * ((t=t/d-1)*t*t*t - 1) + b;
 +
},
 +
easeInOutQuart: function (x, t, b, c, d) {
 +
if ((t/=d/2) < 1) return c/2*t*t*t*t + b;
 +
return -c/2 * ((t-=2)*t*t*t - 2) + b;
 +
},
 +
easeInQuint: function (x, t, b, c, d) {
 +
return c*(t/=d)*t*t*t*t + b;
 +
},
 +
easeOutQuint: function (x, t, b, c, d) {
 +
return c*((t=t/d-1)*t*t*t*t + 1) + b;
 +
},
 +
easeInOutQuint: function (x, t, b, c, d) {
 +
if ((t/=d/2) < 1) return c/2*t*t*t*t*t + b;
 +
return c/2*((t-=2)*t*t*t*t + 2) + b;
 +
},
 +
easeInSine: function (x, t, b, c, d) {
 +
return -c * Math.cos(t/d * (Math.PI/2)) + c + b;
 +
},
 +
easeOutSine: function (x, t, b, c, d) {
 +
return c * Math.sin(t/d * (Math.PI/2)) + b;
 +
},
 +
easeInOutSine: function (x, t, b, c, d) {
 +
return -c/2 * (Math.cos(Math.PI*t/d) - 1) + b;
 +
},
 +
easeInExpo: function (x, t, b, c, d) {
 +
return (t==0) ? b : c * Math.pow(2, 10 * (t/d - 1)) + b;
 +
},
 +
easeOutExpo: function (x, t, b, c, d) {
 +
return (t==d) ? b+c : c * (-Math.pow(2, -10 * t/d) + 1) + b;
 +
},
 +
easeInOutExpo: function (x, t, b, c, d) {
 +
if (t==0) return b;
 +
if (t==d) return b+c;
 +
if ((t/=d/2) < 1) return c/2 * Math.pow(2, 10 * (t - 1)) + b;
 +
return c/2 * (-Math.pow(2, -10 * --t) + 2) + b;
 +
},
 +
easeInCirc: function (x, t, b, c, d) {
 +
return -c * (Math.sqrt(1 - (t/=d)*t) - 1) + b;
 +
},
 +
easeOutCirc: function (x, t, b, c, d) {
 +
return c * Math.sqrt(1 - (t=t/d-1)*t) + b;
 +
},
 +
easeInOutCirc: function (x, t, b, c, d) {
 +
if ((t/=d/2) < 1) return -c/2 * (Math.sqrt(1 - t*t) - 1) + b;
 +
return c/2 * (Math.sqrt(1 - (t-=2)*t) + 1) + b;
 +
},
 +
easeInElastic: function (x, t, b, c, d) {
 +
var s=1.70158;var p=0;var a=c;
 +
if (t==0) return b;  if ((t/=d)==1) return b+c;  if (!p) p=d*.3;
 +
if (a < Math.abs(c)) { a=c; var s=p/4; }
 +
else var s = p/(2*Math.PI) * Math.asin (c/a);
 +
return -(a*Math.pow(2,10*(t-=1)) * Math.sin( (t*d-s)*(2*Math.PI)/p )) + b;
 +
},
 +
easeOutElastic: function (x, t, b, c, d) {
 +
var s=1.70158;var p=0;var a=c;
 +
if (t==0) return b;  if ((t/=d)==1) return b+c;  if (!p) p=d*.3;
 +
if (a < Math.abs(c)) { a=c; var s=p/4; }
 +
else var s = p/(2*Math.PI) * Math.asin (c/a);
 +
return a*Math.pow(2,-10*t) * Math.sin( (t*d-s)*(2*Math.PI)/p ) + c + b;
 +
},
 +
easeInOutElastic: function (x, t, b, c, d) {
 +
var s=1.70158;var p=0;var a=c;
 +
if (t==0) return b;  if ((t/=d/2)==2) return b+c;  if (!p) p=d*(.3*1.5);
 +
if (a < Math.abs(c)) { a=c; var s=p/4; }
 +
else var s = p/(2*Math.PI) * Math.asin (c/a);
 +
if (t < 1) return -.5*(a*Math.pow(2,10*(t-=1)) * Math.sin( (t*d-s)*(2*Math.PI)/p )) + b;
 +
return a*Math.pow(2,-10*(t-=1)) * Math.sin( (t*d-s)*(2*Math.PI)/p )*.5 + c + b;
 +
},
 +
easeInBack: function (x, t, b, c, d, s) {
 +
if (s == undefined) s = 1.70158;
 +
return c*(t/=d)*t*((s+1)*t - s) + b;
 +
},
 +
easeOutBack: function (x, t, b, c, d, s) {
 +
if (s == undefined) s = 1.70158;
 +
return c*((t=t/d-1)*t*((s+1)*t + s) + 1) + b;
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},
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/*
 +
*
 +
* TERMS OF USE - EASING EQUATIONS
 +
*
 +
* Open source under the BSD License.
 +
*
 +
* Copyright © 2001 Robert Penner
 +
* All rights reserved.
 +
*
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* Redistribution and use in source and binary forms, with or without modification,
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* are permitted provided that the following conditions are met:
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*
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* Redistributions of source code must retain the above copyright notice, this list of
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* conditions and the following disclaimer.
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* Redistributions in binary form must reproduce the above copyright notice, this list
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* of conditions and the following disclaimer in the documentation and/or other materials
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* provided with the distribution.
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*
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* Neither the name of the author nor the names of contributors may be used to endorse
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* or promote products derived from this software without specific prior written permission.
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*
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* THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" AND ANY
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* EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF
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* MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE DISCLAIMED. IN NO EVENT SHALL THE
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*  COPYRIGHT OWNER OR CONTRIBUTORS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL,
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*  EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE
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*  GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER CAUSED
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* AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING
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*  NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED
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* OF THE POSSIBILITY OF SUCH DAMAGE.
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*
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*/
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   <script src="https://2017.igem.org/Template:BGIC-Union/newbootstrap-js?action=raw&amp;ctype=text/javascript"></script>
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// dark
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$('.timelineLight').timeline({
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               <div class="col-md-12 col-xs-12 text-center">
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                     <h2>Shenzhen·BGI </h2>
+
                     <h2>Shenzhen·BGI</h2>
−
               <h3 class="animated4"> members from <b>9 </b>cities</h3>
+
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                     <h2>BGIC-Union</h2>
 
                     <h2>BGIC-Union</h2>
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               <h3 class="animated4"> Meet the<b>14</b>of us!</h3>
+
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     <!--/ Slider end -->
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<div class="item" data-id="04/06/2017" data-description="Lorem ipsum dolor sit amet, consectetur adipiscing elit...">
 +
<a href="#" class="image_rollover_bottom">
 +
<img src="images/thumbnails/1.jpg" alt="" />
 +
</a>
 +
<h2>JUNE, 4</h2>
 +
<span></span>
 +
<div class="read_more" data-id="04/06/2012">Read more</div>
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</div>
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<div class="item_open" data-id="04/06/2017">
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<div class="timeline_open_content">
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<h2></h2>
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<div class="item" data-id="12/06/2017" data-description="Lorem ipsum dolor sit amet, consectetur adipiscing elit...">
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<a href="#" class="image_rollover_bottom">
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<img src="images/thumbnails/2.jpg" alt="" />
 +
</a>
 +
<h2>JUNE, 12</h2>
 +
<span></span><div class="read_more" data-id="12/06/2012">Read more</div>
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</div>
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<div class="item_open" data-id="12/06/2017">
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<div class="timeline_open_content">
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<h2></h2>
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<div class="item" data-id="21/06/2017" data-description="Lorem ipsum dolor sit amet, consectetur adipiscing elit...">
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<a href="#" class="image_rollover_bottom">
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<img src="images/thumbnails/3.jpg" alt="" />
 +
</a>
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<h2>JUNE, 21</h2>
 +
<span></span><div class="read_more" data-id="21/06/2012">Read more</div>
 +
</div>
 +
<div class="item_open" data-id="21/06/2017">
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<h2></h2>
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</div> <!-- /END TIMELINE -->
 
<!-- +++++ Welcome Section +++++ -->
 
<!-- +++++ Welcome Section +++++ -->
 
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<h4>BGIC-COLLEGE 2017</h4>
 
<h4>BGIC-COLLEGE 2017</h4>
 
<img src="https://static.igem.org/mediawiki/2017/d/de/Repute-logo-light.png" width="60px" height="72px"></img>
 
<img src="https://static.igem.org/mediawiki/2017/d/de/Repute-logo-light.png" width="60px" height="72px"></img>
−
<p></br><i>TWITTER:@BGIC-Union</i> </p>
+
<p></br><i class="fa-twitter">TWITTER:@BGIC-Union</i> </p>
 
 
 
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Revision as of 11:37, 3 September 2017

Team：BGIC-Union

JUNE, 4

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JUNE, 12

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JUNE, 21

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Hi, I am dCasentry,

a T7—dCas9 multi-output DNA sensor designed to detect ctDNA!

Cancer is a leading cause of death worldwide, accounting for 8.8 million deaths in 2015, and the most common causes of cancer death is lung cancer (1.69 million deaths). Nowadays, multiple lung cancer detection methods are developed, and I can be an assistant in liquid biopsy whose detection minimizes trauma and pain. The tumor marker I detect is circulating tumor DNA (ctDNA), tumor-derived fragmented DNA in the bloodstream that is not associated with cells. It is released by the dying cells during the biological process of apotheosis and necrosis, or active release from viable tumor cells.

I am an improved version of the paired dCas9 system designed by 2015 Peking university iGEM, composing of sgRNA, a pair of dCas9 protein and a split T7 RNA polymerase switch connected to each dCas9 protein via a linker. The sgRNA is designed to detect target genes and I will complete my task according to this order: First, the sgRNA will instruct each sgRNA-dCas9 complex to certain locus. Next, unlike Peking University, a T7 RNA polymerase rather than a luciferase is split apart and connected to dCas9 protein via a linker. I call them NT7-dCas9 and CT7-dCas9. Once two sgRNA are attached to the target sequence, two split parts will reunion and reassemble to form a complete RNA polymerase and start transcription consistently, which means even though the initial ctDNA concentration is low, the signal will continue to be magnified until it can be observed. Also, there is no limit on the content I can transcribed, that is, I am able to give out many kinds of signals, including GFP, RFP or LacZ.

In this project my main goal is to detect the fusion gene EML4-ALK. Some of the cancer, including non small cell lung cancer (NSCLC), is caused by gene fusion. When two respective original genes fuse together, it produces the expression product of fusion gene, which induced the canceration of cells. EML4-ALK exists only in NSCLC patients’ blood which prevents false positive result during detection and there is a specific targeted drug for this mutation which means patients can have precise treatment as soon as possible when the detection result is positive. My work is meaningful.

Finally, as a well-rounded and efficient lung cancer fusion gene detection sentry, I am proud to point out this important reason why you can trust me —I can carry out a simpler liquid biopsy process. Although the liquid biopsy avoid copliacation, common liquid biopsy required laboratory apparatus such as PCR instrument during the detection of ctDNA. In my work, my DNA device and proteins that needed for detection will mixed in a E.coli cell-free system and freeze-dried on a paper screening chip. You will be seeing me in a convenient kit that contains all tools you need for detection, including hemostix, a hand power centrifuge, NASBA reaction system and the paper screening chip.

Please, click here and know more about me as well as the product!

EXTRACT

CENTRIFUGE

ctDNA AMPLIFICATION

DETECTION

SIGNALING

TEST CHIP