Difference between revisions of "Team:KUAS Korea/Description"

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<h4>Why is Knowing Gut Environment Important?</h4>
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<p><font size=4px>The environment of a gut is a promising field of study, in which it can mirror the health status of an individual.</font> </p>
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<p><font size=4px>In aspects of Obesity, recent studies found out diversity in gut flora differs between obese people and lean people. Obese people tend to have less diversity in gut bacteria and showed an increase in ratio of Firmicutes/Bacteroidetes bacteria. This ratio results in a different pattern when a specific disease occurs. Furthermore, based on the fact that lymphatic tissue in intestine holds the largest pool of immune cells in human body, gut microbiota protects the host from infection and increase the epithelial barrier. Especially in case of babies, babies who fed breast milk had more gut bacteria diversity than formula fed babies. In addition, gut microbiota shows immune-regulative role in autoimmune diseases such as EAE, inflammatory diseases such as RA(Rheumatoid Arthritis), IBD(Inflammatory Bowel Disease) and Type I diabetes. The distribution of various gut micro bacterium may also influence the brain network. Signals originated from endocrine, neurocrine, and inflammation-related ones made by the gut microbiota can affect the brain. Also in reverse, many types of research proved that brain could regulate microbial composition and function via endocrine and neural interactions. A 2011 study in mice found out the gut microbe ratio had an impact on anxiety, depression, stress and cognition ability. </font> </p>
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<p><font size=4px> With the stool showing our current health state, we could use this as a great tool to analyze our health. Our project introduces a more simple and efficient disease detector applying this significant indicator. </font> </p>
  
 
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<h4>1. Prepare catholyte and anolyte</h4>
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<p><font size=4>The hssR and hssS mechanism of our project is as follows.</font></p>
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<p> <font size=4>      ① If intestinal bleeding occurs for a variety of reasons, blood leak into the bowel.<br>
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      ② When heme in the blood binds to the HssS protein, it phosphorylates histidine 249 through autophosphorylation.<br>
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      ③ HssS transfers the phosphate group from its histidine 249 to aspartate 52 of HssR using transphosphorylation.<br>
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      ④ The phosphorylated HssR binds to the direct repeat sequence of the hrtAB promoter and initiates the reporter’s transcription.<br>
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<h4>2. Prepare catholyte and anolyte</h4><br>
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<p><font size=4>Also, the mechanism of heme detection using hrtR protein is as follows.</font></p>
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<p> <font size=4>      ①If intestinal bleeding occurs for a variety of reasons, blood leak into the bowel.<br>
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      ② When heme binds to the HrtR protein, HrtR binds to the promoter in front of the hrtR sequence and promotes its own transcription.<br>
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      ③ The reporter behind the hrtR sequence is transcribed together to determine the presence of heme detection.<br>
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Revision as of 12:02, 7 October 2017

Description

POO-robiotics

Why is Knowing Gut Environment Important?

The environment of a gut is a promising field of study, in which it can mirror the health status of an individual.



In aspects of Obesity, recent studies found out diversity in gut flora differs between obese people and lean people. Obese people tend to have less diversity in gut bacteria and showed an increase in ratio of Firmicutes/Bacteroidetes bacteria. This ratio results in a different pattern when a specific disease occurs. Furthermore, based on the fact that lymphatic tissue in intestine holds the largest pool of immune cells in human body, gut microbiota protects the host from infection and increase the epithelial barrier. Especially in case of babies, babies who fed breast milk had more gut bacteria diversity than formula fed babies. In addition, gut microbiota shows immune-regulative role in autoimmune diseases such as EAE, inflammatory diseases such as RA(Rheumatoid Arthritis), IBD(Inflammatory Bowel Disease) and Type I diabetes. The distribution of various gut micro bacterium may also influence the brain network. Signals originated from endocrine, neurocrine, and inflammation-related ones made by the gut microbiota can affect the brain. Also in reverse, many types of research proved that brain could regulate microbial composition and function via endocrine and neural interactions. A 2011 study in mice found out the gut microbe ratio had an impact on anxiety, depression, stress and cognition ability.


With the stool showing our current health state, we could use this as a great tool to analyze our health. Our project introduces a more simple and efficient disease detector applying this significant indicator.