Difference between revisions of "Team:TNCR Korea"

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What is the problem with gluten food?<br>
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Gluten-contaning food is staple food in the daily human diet, including wheat, barley and rye. It is used to give the chewy texture to the final products. Gliadins and glutenins are the two main components of the gluten. Especially, incomplete breakdown of gliadin which is rich in proline is associated with the development of celiac disease(CD) and disorder such as depression and schizophrenia. Gliadinomorphin-7 (Tyr-Pro-Gln-Pro-Gln-Pro-Phe), is an intermediate product of gliadin, are finally cleaved by Dipeptidyl peptidase IV(DPP4) that can cleave N-terminal dipeptides with proline at the second position. Remaining tripeptide acts as a inhibitor of DPP4. DPP4 inactivity leads to the incomplete breakdown of gluten and can increase the diseases mentioned above. Thus, people who have gluten sensitivity need to additional DPP4 for gluten digestion.<br><br><br>
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<h2>We make Gluten digestable. </h2>
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What's the difference between health people and gluten sensitivity people? Is it coming from genetic defect? or digestion activity of intestinal bacteria?  That's what we want to address by experimental approaches. <br><br><br>
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Approach<br>
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Team TNCR-Korea is focusing on the intestinal bacteria (Gut microflora) and has set hypothesis that introducing the DPP4 gene into intestinal bacteria of gluten sensitivity people may help their gluten indigestion caused by incomplete breakdown.<br><br><br>
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<span style=" font: bold 1.5em/1em Georgia, serif ; color: blue;">
 
Method<br>
 
</span>
 
 
1. Analysis of intestinal bacterial flora in gluten sensitivity people<br><br>
 
2. Dominant bacteria selection which have strong activity of DPP4.<br><br>
 
3. Introduction of DPP4 to the dominant gut bacteria of weak DPP4 activities by gene cloning and transformation methods.<br><br>
 
4. Yogurt-type intake of probiotics (beneficial bacteria) with recombinant DPP4 construct. <br><br><br><br>
 
 
 
<span style=" font: bold 1.5em/1em Georgia, serif ; color: blue;">
 
reference<br>
 
</span>
 
 
 
1. https://en.wikipedia.org/wiki/Gluten<br>
 
2. https://en.wikipedia.org/wiki/Gliadin<br>
 
3. Pruimboom L, de Punder K. (2015). The opioid effects of gluten exorphins:          asymptomatic celiac disease. J Health Popul Nutr. 33:24<br>
 
4. Detel D, Persić M, Varljen J. (2007). Serum and intestinal dipeptidyl peptidase IV    (DPP IV/CD26) activity in children with celiac disease. J Pediatr Gastroenterol      Nutr. 45(1):65-70.<br><br><br>
 
 
<span style=" font: bold 1.5em/1em Georgia, serif ; color: blue;">
 
Image reference<br>
 
</span>
 
 
1. https://www.glutenfreegigi.com/celiac-disease-versus-gluten-sensitivity/<br>
 
2. https://www.organicfacts.net/coeliac-disease-gluten-intolerance.html<br>
 
3. https://en.wikipedia.org/wiki/Dipeptidyl_peptidase-4<br>
 
4. http://www.ezbalance.com/how-to-colonize-your-gut-with-beneficial-bacteria/<br>
 
5, http://www.di.uq.edu.au/proj4aproc<br>
 
6. https://www.sciencedaily.com/releases/2013/05/130515113744.htm<br>
 
7. http://uinkin.tistory.com/<br>
 
8. http://www.yesvegetarian.com/is-yogurt-your-favorite-then-you-need-to-read-this<br>
 
<br>
 
 
<span style=" font: bold 1.5em/1em Georgia, serif ; color: blue;">
 
LAB<br>
 
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UPLOAD FILES
 
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Revision as of 09:23, 27 October 2017

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	TNCR_KOREA — Digestable Gluten
	
	
	
	


	
	
	
	
	
	
	
	
	


	

	
	
	
	
	
	
	
	
	
	

	


	
	
	
	

	
	
		

We make Gluten digestable.

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Our Lab

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What We Do

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Web Development

Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts.

GluTNCR

Detecting Gluten with TensorFlow. GluTNCR is a powerful app that detects a food that has Gluten. All you need is the image.

Gluten Free Recipes

We make videos of how to make foods without Gluten. Videos are on Youtube! Now you may eat.

Video Editing

Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts.

SEO Ranking

Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts.

Cloud Based Apps

Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts.

What Ryan Dreams

Ryan is our team leader. He fucks well. He's kind of a bad ass.

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“Creativity is just connecting things. When you ask creative people how they did something, they feel a little guilty because they didn’t really do it, they just saw something. It seemed obvious to them after a while.”

Ryan Kang, TNCR_KOREA Leader

Meet US on...

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Facebook Page

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Instagram

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IGEM Website

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Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts.

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