Difference between revisions of "Team:AFCM-Egypt"
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<meta name="viewport" content="width=device-width, initial-scale=1.0"> | <meta name="viewport" content="width=device-width, initial-scale=1.0"> | ||
</head> | </head> | ||
| + | <style> | ||
| + | |||
| + | .buttons { | ||
| + | display: table; | ||
| + | height: 100%; | ||
| + | width: 100%; | ||
| + | } | ||
| + | |||
| + | p a { | ||
| + | background: rgba(255, 255, 255, 0); | ||
| + | border-bottom: 1px solid; | ||
| + | color: #fff; | ||
| + | line-height: 1.4; | ||
| + | padding: .25em; | ||
| + | text-decoration: none; | ||
| + | } | ||
| + | p a:hover { | ||
| + | background: white; | ||
| + | color: #E1332D; | ||
| + | } | ||
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| + | .btn { | ||
| + | color: #fff; | ||
| + | cursor: pointer; | ||
| + | display: block; | ||
| + | font-size: 16px; | ||
| + | font-weight: 400; | ||
| + | line-height: 45px; | ||
| + | margin: 0 auto 2em; | ||
| + | max-width: 160px; | ||
| + | position: relative; | ||
| + | text-decoration: none; | ||
| + | text-transform: uppercase; | ||
| + | vertical-align: middle; | ||
| + | width: 100%; | ||
| + | } | ||
| + | @media (min-width: 400px) { | ||
| + | .btn { | ||
| + | display: inline-block; | ||
| + | margin-right: 2.5em; | ||
| + | } | ||
| + | .btn:nth-of-type(even) { | ||
| + | margin-right: 0; | ||
| + | } | ||
| + | } | ||
| + | @media (min-width: 600px) { | ||
| + | .btn:nth-of-type(even) { | ||
| + | margin-right: 2.5em; | ||
| + | } | ||
| + | .btn:nth-of-type(5) { | ||
| + | margin-right: 0; | ||
| + | } | ||
| + | } | ||
| + | .btn:hover { | ||
| + | text-decoration: none; | ||
| + | } | ||
| + | .btn-5 { | ||
| + | border: 0 solid; | ||
| + | box-shadow: inset 0 0 20px rgba(255, 255, 255, 0); | ||
| + | outline: 1px solid; | ||
| + | outline-color: rgba(255, 255, 255, 0.5); | ||
| + | outline-offset: 0px; | ||
| + | text-shadow: none; | ||
| + | -webkit-transition: all 1250ms cubic-bezier(0.19, 1, 0.22, 1); | ||
| + | transition: all 1250ms cubic-bezier(0.19, 1, 0.22, 1); | ||
| + | } | ||
| + | .btn-5:hover { | ||
| + | border: 1px solid; | ||
| + | box-shadow: inset 0 0 20px rgba(255, 255, 255, 0.5), 0 0 20px rgba(255, 255, 255, 0.2); | ||
| + | outline-color: rgba(255, 255, 255, 0); | ||
| + | outline-offset: 15px; | ||
| + | text-shadow: 1px 1px 2px #427388; | ||
| + | } | ||
| + | |||
| + | .dots { | ||
| + | height:13px; | ||
| + | width:13px; | ||
| + | display:inline-block; | ||
| + | padding:5px; | ||
| + | background-color:gray; | ||
| + | border-radius:50px; | ||
| + | cursor:pointer; | ||
| + | } | ||
| + | .adots { | ||
| + | background-color:#f70404; | ||
| + | } | ||
| + | </style> | ||
<body> | <body> | ||
<section class="header" id="header"> | <section class="header" id="header"> | ||
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<h2 class='text-center' style='margin-bottom:30px'>AFCM-Egypt</h3> | <h2 class='text-center' style='margin-bottom:30px'>AFCM-Egypt</h3> | ||
<h3 class='text-center'> We strive to excel</h4> | <h3 class='text-center'> We strive to excel</h4> | ||
| − | + | <a href="http://www.afcm.ac.eg" class="btn btn-5">Hover</a> | |
| + | |||
</div> | </div> | ||
<div class='col-md-3'><img src="https://static.igem.org/mediawiki/2017/7/7b/AFCM_LOGO_PNG.png" alt="logo" style='width: 50%;float: right'></div> | <div class='col-md-3'><img src="https://static.igem.org/mediawiki/2017/7/7b/AFCM_LOGO_PNG.png" alt="logo" style='width: 50%;float: right'></div> | ||
Revision as of 10:43, 17 October 2017
Abstract
Knock-in of Circular RNA gene in Hepatocellular Carcinoma cells via CRISPR/Cas9
Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers
in males and next to breast cancer among females in Egypt - based upon results of National Cancer Registry Program of Egypt-.
"Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique
that we will be using to modulate a certain circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma.
This in consequence modifies miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials.
This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is accomplished by utilizing a synthetic circuit to give rise to a springboard in our battle against cancer.
Hepatocellular Carcinoma (HCC) is the leading cause of cancer deaths worldwide & ranked first among cancers in males and next to breast cancer among females in Egypt - based upon results of National Cancer Registry Program of Egypt-. "Grabbing the problem from the roots" is the best way to decently describe the use of CRISPR, a special gene editing technique that we will be using to modulate a certain circRNA and adjust its gene expression, which is down-regulated in hepatocellular carcinoma. This in consequence modifies miRNA expression thus amending the mRNA gene expression; which is the visible problem in our trials. This will lead us to adopt a novel strategy for miRNA suppression by using circRNAs. This is accomplished by utilizing a synthetic circuit to give rise to a springboard in our battle against cancer.
AFCM-Egypt
We strive to excel
Hover
