Difference between revisions of "Team:Tsinghua-A/Model"

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<h3>★  ALERT! </h3>
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<p>This page is used by the judges to evaluate your team for the <a href="https://2017.igem.org/Judging/Medals">medal criterion</a> or <a href="https://2017.igem.org/Judging/Awards"> award listed above</a>. </p>
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<h1> Modeling</h1>
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<p>Mathematical models and computer simulations provide a great way to describe the function and operation of BioBrick Parts and Devices. Synthetic Biology is an engineering discipline, and part of engineering is simulation and modeling to determine the behavior of your design before you build it. Designing and simulating can be iterated many times in a computer before moving to the lab. This award is for teams who build a model of their system and use it to inform system design or simulate expected behavior in conjunction with experiments in the wetlab.</p>
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  <div class="myPara" >&nbsp;&nbsp;&nbsp;&nbsp;Since there are many kinds of E.coli in our system, it is difficult to understand the behavior of the system directly without model. Also, with an appropriate model, we can combine it with our experiment results to help us design our gene circuit. <br>
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&nbsp;&nbsp;&nbsp;&nbsp;First, to adapt to our experiment design, we construct a complete fluid model which describes the growth of E.coli inside the fluid medium using Ordinary Differential Equation (ODE). This complete fluid model can help us describe the change of all six character’s amount. Furthermore, the fluid E.coli War is based on this model. <br>
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&nbsp;&nbsp;&nbsp;&nbsp;As is stated in the orthogonality test in experiment part, we failed to find the orthometric gene circuit for two warriors. How can we solve this problem? Our model can tell us answer!<br>
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&nbsp;&nbsp;&nbsp;&nbsp;However, complete fluid model is too complicated to instruct our experiment design. Therefore, we extracted parts of the model to help us design a good warrior I which just respond to the AHL secreted by warrior II but not itself. This can be seen on the page of Improved orthometric gene circuit.What’s more, the simplified model tells us how to regulate the killing ability of warrior experimentally.Detailed information is displayed on the page of Regulation of killing ability. <br>
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&nbsp;&nbsp;&nbsp;&nbsp;Apart from things mentioned above, spatial factors also have a great impact on the results of population competition and cooperation. To understand spatial effects better, we developed our discrete probabilistic solid model, and this model is used as the basis of our solid E.coli War.
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Revision as of 13:39, 22 October 2017

HOME
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Part Collection
SAFETY
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Hardware
Measurement
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JUDGING FORM
Discription
Overview
    Since there are many kinds of E.coli in our system, it is difficult to understand the behavior of the system directly without model. Also, with an appropriate model, we can combine it with our experiment results to help us design our gene circuit.
    First, to adapt to our experiment design, we construct a complete fluid model which describes the growth of E.coli inside the fluid medium using Ordinary Differential Equation (ODE). This complete fluid model can help us describe the change of all six character’s amount. Furthermore, the fluid E.coli War is based on this model.
    As is stated in the orthogonality test in experiment part, we failed to find the orthometric gene circuit for two warriors. How can we solve this problem? Our model can tell us answer!
    However, complete fluid model is too complicated to instruct our experiment design. Therefore, we extracted parts of the model to help us design a good warrior I which just respond to the AHL secreted by warrior II but not itself. This can be seen on the page of Improved orthometric gene circuit.What’s more, the simplified model tells us how to regulate the killing ability of warrior experimentally.Detailed information is displayed on the page of Regulation of killing ability.
    Apart from things mentioned above, spatial factors also have a great impact on the results of population competition and cooperation. To understand spatial effects better, we developed our discrete probabilistic solid model, and this model is used as the basis of our solid E.coli War.

TSINGHUA-A IGEM