Difference between revisions of "Team:SCU China"
| Line 125: | Line 125: | ||
width: 90%; | width: 90%; | ||
margin-top: 30px; | margin-top: 30px; | ||
| − | margin | + | margin:60px; |
font-size: 24px !important; | font-size: 24px !important; | ||
line-height: 34px !important; | line-height: 34px !important; | ||
| − | + | text-align:justify; | |
| − | text-align: | + | text-align-last:left; |
| − | text-align-last: | + | |
font-family: "columbia","Times New Roman", Georgia,Serif, sans-serif; | font-family: "columbia","Times New Roman", Georgia,Serif, sans-serif; | ||
} | } | ||
| Line 160: | Line 159: | ||
line-height: 34px; | line-height: 34px; | ||
text-align:justify; | text-align:justify; | ||
| − | + | text-align-last:left | |
font-family:"columbia", "Times New Roman", Georgia,Serif, sans-serif; | font-family:"columbia", "Times New Roman", Georgia,Serif, sans-serif; | ||
} | } | ||
| Line 222: | Line 221: | ||
Rhythmic Production of Melatonin in <i>E.coli</i> | Rhythmic Production of Melatonin in <i>E.coli</i> | ||
</h3> | </h3> | ||
| − | <div class="scu_content"> | + | <div class="scu_content" > |
Nowadays, insomnia and circadian rhythm disorders are | Nowadays, insomnia and circadian rhythm disorders are | ||
increasingly plaguing individuals' daily life. According to NIH reports, around 50-70 | increasingly plaguing individuals' daily life. According to NIH reports, around 50-70 | ||
Revision as of 07:42, 28 June 2017
Rhythmic Production of Melatonin in E.coli
Nowadays, insomnia and circadian rhythm disorders are
increasingly plaguing individuals' daily life. According to NIH reports, around 50-70
million U.S. adults are suffering from sleep insufficiency and poor-quality sleep. The
circadian rhythm in human is predominantly under the regulation of melatonin, a hormone
produced by pineal gland periodically. This year we want to use engineered E.coli to mimic
this process in human. We propose to construct a melatonin biosynthesis pathway in E.coli to
produce melatonin, while simultaneously couple this process with periodically-optimized
repressilator, a synthetic genetic oscillator with higher precision, with the intention to
render melatonin production resemble mammalian periodicity in E.coli.
