Difference between revisions of "Team:TAS Taipei"
| Line 24: | Line 24: | ||
<link rel="stylesheet" href="https://2015.igem.org/Template:TAS_Taipei/css/bootstrap?action=raw&ctype=text/css"> | <link rel="stylesheet" href="https://2015.igem.org/Template:TAS_Taipei/css/bootstrap?action=raw&ctype=text/css"> | ||
| + | <head> | ||
| + | <meta charset="utf-8"> | ||
| + | <meta http-equiv="X-UA-Compatible" content="IE=edge"> | ||
| + | <meta name="viewport" content="width=device-width, initial-scale=1"> | ||
| + | <!-- The above 3 meta tags *must* come first in the head; any other head content must come *after* these tags --> | ||
| + | <title>Bootstrap 101 Template</title> | ||
| + | <!-- Bootstrap --> | ||
| + | <link href="css/bootstrap.min.css" rel="stylesheet"> | ||
| + | |||
| + | <!-- HTML5 shim and Respond.js for IE8 support of HTML5 elements and media queries --> | ||
| + | <!-- WARNING: Respond.js doesn't work if you view the page via file:// --> | ||
| + | <!--[if lt IE 9]> | ||
| + | <script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script> | ||
| + | <script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script> | ||
| + | <![endif]--> | ||
| + | </head> | ||
| + | <body> | ||
| + | <h1>Hello, world!</h1> | ||
| + | |||
| + | <!-- jQuery (necessary for Bootstrap's JavaScript plugins) --> | ||
| + | <script src="https://ajax.googleapis.com/ajax/libs/jquery/1.12.4/jquery.min.js"></script> | ||
| + | <!-- Include all compiled plugins (below), or include individual files as needed --> | ||
| + | <script src="js/bootstrap.min.js"></script> | ||
<script>localStorage.clear();</script> | <script>localStorage.clear();</script> | ||
Revision as of 06:37, 17 May 2017
Hello, world!
ABSTRACT
Cataracts, the clouding of the lens, cause half of the world's blindness. Most cataracts are age-related and arise when crystallin proteins in the lens become oxidized and aggregate over time. Surgery is currently the only recognized treatment to effectively cure cataracts, but this method is expensive and invasive. Therefore, we formulated a natural and non-invasive alternative. In the eye, a natural antioxidant glutathione (GSH)—produced by the enzyme glutathione reductase (GSR)—exists to combat oxidation, but GSH levels decrease with age. Studies have also suggested that another enzyme—25-hydroxylase (CH25H)—can convert cholesterol in the eye into 25-hydroxycholesterol (25HC), which reverses crystallin aggregation. We expressed and purified GSR and CH25H for the prevention and treatment of cataracts, respectively. To deliver these proteins through the cornea and into the lens, we engineered biodegradable chitosan nanoparticles, thus creating a natural and non-invasive alternative to surgery.
