Skywalkerest (Talk | contribs) |
Skywalkerest (Talk | contribs) |
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− | <h2>1.Increase the production of B12 in B. megaterium</h2> | + | |
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+ | <h1>Overview</h1> | ||
+ | <ul id="cont"> | ||
+ | <h3> In general, we aim to apply a novel dehalogenase, RdhANP, to treat industrial wastewaters by degrading the persistent and toxic pollutant, halogenated organics. To optimize its application, on the one hand, we used some conventional synthetic biological methods for reference to increase the production of functional dehalogenase. On the other hand, we planned to introduce our engineered bacterium, B. megaterium into hybrid membrane bioreactor(HMBR) to make our project more practical. In this way, we'll also do some engineering work on our B. megaterium. | ||
+ | </h3> | ||
+ | <h2>1.Increase the production of B12 in B. megaterium</h2> | ||
1.1 Increase flux of glutamyl-tRNA to uroporphyrinogen Ⅲ by regulating feedback inhibition of glutamyl-tRNA reductase (HemA) | 1.1 Increase flux of glutamyl-tRNA to uroporphyrinogen Ⅲ by regulating feedback inhibition of glutamyl-tRNA reductase (HemA) | ||
1.2 Reduce flux of uroporphyrinogen Ⅲ to heme by an antisense RNA(as) strategy | 1.2 Reduce flux of uroporphyrinogen Ⅲ to heme by an antisense RNA(as) strategy | ||
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<h2>8.Introduce downstream devices to eliminate microorganisms leaked into the effluent</h2> | <h2>8.Introduce downstream devices to eliminate microorganisms leaked into the effluent</h2> | ||
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Revision as of 07:04, 23 October 2017
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