Difference between revisions of "Team:SCU China"
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repressilator</strong>, a synthetic genetic oscillator with higher precision, with the intention to <strong>render melatonin production | repressilator</strong>, a synthetic genetic oscillator with higher precision, with the intention to <strong>render melatonin production | ||
resemble mammalian periodicity in<i> E.coli</i>.</strong> </p> | resemble mammalian periodicity in<i> E.coli</i>.</strong> </p> | ||
| − | <div id="scu_down"> | + | <div class="scu_down" id="scu_down"> |
<p class="scu_down">learn more about us</p> | <p class="scu_down">learn more about us</p> | ||
<img id="scu_down_image" class="scu_down_scale" | <img id="scu_down_image" class="scu_down_scale" | ||
Revision as of 15:27, 27 October 2017
Rhythmic Production of Melatonin in E.coli
Nowadays, insomnia and circadian rhythm disorders are increasingly plaguing individuals' daily life. According to NIH reports, around 50-70 million U.S. adults are suffering from sleep insufficiency and poor-quality sleep. The circadian rhythm in human is predominantly under the regulation of melatonin, a hormone produced by pineal gland periodically. This year we want to use engineered E.coli to mimic this process in human. We propose to construct a melatonin biosynthesis pathway in E.coli to produce melatonin, while simultaneously couple this process with periodically-optimized repressilator, a synthetic genetic oscillator with higher precision, with the intention to render melatonin production resemble mammalian periodicity in E.coli.
learn more about us
