Description

Tell us about your project, describe what moves you and why this is something important for your team.

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• A clear and concise description of your project.
• A detailed explanation of why your team chose to work on this particular project.
• References and sources to document your research.
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A special, civilian-friendly treatment of cancer

According to statistics, there are more than 14 million people suffering from cancer every year, and more than 32 million people died of cancer at the same period. Its causes are complex and variable, which means that it’s difficult to cure. Among the complex causes of cancer, BRAF is one of the most common proto-oncogene. Its changes have become the most probable genetic changes in adamantoblastoma. BRAF is also the most common mutant gene of melanoma. The incidence of mutations reach up to 40% to 60%.

Nowadays, the treatments to cancer are mainly surgical treatment, radiation therapy and chemotherapy, they are very harmful to human body. In addition, using these treatment, the treatment cycle is long and the price is too expensive. In fact, these treatment are not quiet useful for anyone. All these aspect need to be improved now.

In order to solve these problems, we are exploring the relationship between the genetic mutation of BRAF and the growth and the reproduction of the tumor. We, the SFLS_iGEMers, are hoping that by using Crisper-Cas9 and short microRNA to interference or removal, we can successfully complete three steps of “discovery, mark, kill” to achieve the ideal treatment, which is efficient, hurt less, cost less and can fit everyone.

A new therapeutic agent for Staphylococcus aureus infection: improvement and application of human defensin HBD3

Staphylococcus aureus infection is a worldwide health problem. The US Centers for Disease Control reports that infections caused by Staphylococcus aureus are second only to E. coli. Among them, Staphylococcus aureus caused by food poisoning, in all countries have a considerable proportion. Due to the presence of MRSA (methicillin-resistant Staphylococcus aureus), penicillin is generally not used. So there are Staphylococcus aureus infection, generally with erythromycin, new penicillin, gentamicin, vancomycin or vindicamycin vi treatment.

Our goal is to use the human defensin hBD3 - a broad spectrum of antibacterial peptides to solve the problem The current recognized HBD3 bactericidal mechanism is: with a large number of positively charged HBD3 and low-charge cell wall binding, cell death The Due to the special mechanism of action, HBD3 extremely difficult to make Staphylococcus aureus produce resistance. At the same time, synthetic biology provides the possibility for mass production.