Difference between revisions of "Team:UCLouvain"

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{{UCLouvain}}
 
{{UCLouvain}}
 
<html>
 
<html>
<header class="main-header">
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    <head>
<div class="container">
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<title>iGEM UCLouvain Team</title>
<div class="logo">
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<a href="./Team:UCLouvain"><img src="https://static.igem.org/mediawiki/2017/3/3d/UCLouvain_igem_logo.png" alt="logo"></a>
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.igem_2017_content_wrapper footer,
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.igem_2017_content_wrapper ul {
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<div class="menu">
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/*
<nav class="desktop-nav">
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Our styles
<ul class="first-level">
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*/
<li><a href="./Team:UCLouvain" class="animsition-link">Home</a></li>
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<li><a href="./Team:UCLouvain/OurProject/Overview">our project</a>
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<ul class="second-level">
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<li><a href="/Team:UCLouvain/OurProject/Overview" class="animsition-link">overview</a></li>
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<li><a href="/Team:UCLouvain/Approach1" class="animsition-link">auxotrophs</a></li>
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<li><a href="/Team:UCLouvain/Approach2" class="animsition-link">comR/S</a></li>
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<li><a href="/Team:UCLouvain/Badge" class="animsition-link">badge</a></li>
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</ul>
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</li>
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<li><a href="/Team:UCLouvain/InTheLab/Overview">in the lab</a>
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<ul class="second-level">
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<li><a href="/Team:UCLouvain/InterLab" class="animsition-link">interlab</a></li>
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<li><a href="/Team:UCLouvain/Protocols" class="animsition-link">protocols</a></li>
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<li><a href="/Team:UCLouvain/Parts" class="animsition-link">parts</a></li>
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</ul>
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</li>
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<li><a href="/Team:UCLouvain/HP/Silver" class="animsition-link">human practices</a></li>
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<li><a href="/Team:UCLouvain/Collaboration">collaboration</a></li>
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<li><a href="/Team:UCLouvain/AboutUs">about us</a>
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<ul class="second-level">
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<li><a href="/Team:UCLouvain/Team" class="animsition-link">team</a></li>
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<li><a href="/Team:UCLouvain/Aknowledgement" class="animsition-link">aknowledgement</a></li>
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<li><a href="/Team:UCLouvain/OurUniversity" class="animsition-link">our university</a></li>
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<li><a href="/Team:UCLouvain/OurEvents" class="animsition-link">our events</a></li>
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<li><a href="/Team:UCLouvain/Attributions" class="animsition-link">attributions</a></li>
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</ul>
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</li>
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<li><a href="/2017_Judging_Form?team=UCLouvain">judging form</a></li>
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</ul>
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<nav class="mobile-nav"></nav>
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<div class="menu-icon">
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<div class="line"></div>
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<div class="line"></div>
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<div class="line"></div>
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</div>
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</div>
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</div>
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</header>
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<div class="site-hero">
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/* Import Roboto */
<ul class="slides">
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@import url('https://fonts.googleapis.com/css?family=Roboto:300,400,700');
<li>
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<div><span class="small-title uppercase montserrat-text">we are</span></div>
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<div class="big-title uppercase montserrat-text"><span style="text-transform:none;">i</span>GEM UCLouvain Team</div>
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</li>
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</ul>
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</div>
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<div class="container">
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<div class="project">
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<div class="col-md-5 col-sm-12">
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<div class="row">
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<img src="assets/img/project.jpg" alt="image">
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</div>
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<div class="col-md-offset-1 col-md-6 col-sm-12">
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<div class="row">
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<div class="section-title">
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<span>the project</span>
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</div>
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<p>
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Although melanoma accounts for less than one percent of skin cancer cases, they are responsible for the vast majority of skin cancer deaths. More than 80% of melanomas are caused by the exposure to ultraviolet (UV) radiation from the sun.
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</p>
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<p>
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<b>Our project:</b> <b style="font-family:'Brush Script MT';font-size:21px;">BactaSun</b>, a bio-badge changing color when exposed to sunlight.
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</p>
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<a href="#" class="btn blue" style="float:right;margin-top:30px"><span>read more</span></a>
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</div>
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</div>
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</div>
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</div>
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<section class="services">
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<div class="row" style="margin-bottom:50px">
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<div class="col-md-6 col-sm-12">
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<div class="row">
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<a href="" style="color:#60606e !important;"><i class="icon ion-arrow-graph-up-right"></i>
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<span class="montserrat-text uppercase service-title">Global issue</span>
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<p style="padding-right: 30px;">For several years, our exposition to UV rays has <b>increased</b> and scientists noticed an <b>upward trend</b> in risks of developing skin cancers.</p></a>
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</div>
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</div>
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<div class="col-md-6 col-sm-12">
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<div class="row">
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<a href="" style="color:#60606e !important;"><i class="icon ion-ios-glasses"></i>
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<span class="montserrat-text uppercase service-title">Protection exists</span>
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<p style="padding-right: 30px;">Although protections exist to avoid this issue, <b>we can’t feel the UV rays</b>, or too late.</p></a>
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</div>
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</div>
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</div>
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<div class="row">
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<div class="col-md-6 col-sm-12">
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<div class="row">
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<a href="" style="color:#60606e !important;"><i class="icon ion-android-watch"></i>
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<span class="montserrat-text uppercase service-title">Badge design</span>
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<p style="padding-right: 30px;">For that reason, we developed a <b>wearable UV-sensitive badge</b> so that people can be warned <b>anytime and anywhere</b> of their UV exposition. The badge turns red when exposed to UVs.</p></a>
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</div>
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</div>
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<div class="col-md-6 col-sm-12">
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<div class="row">
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<a href="" style="color:#60606e !important;"><i class="icon ion-erlenmeyer-flask"></i>
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<span class="montserrat-text uppercase service-title">Culture design</span>
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<p style="padding-right: 30px;">This badge contains a <b>liquid cell culture</b>. The cells are engineered so that they can produce a red fluorescent protein. They only produce it when the badge is exposed to UV rays, thanks to a <b>photocaged amino acid</b>.</p></a>
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</div>
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</div>
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</div>
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</div>
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<div class="col-md-5 col-sm-12 services-right wow fadeInUp" data-wow-delay=".1s">
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you think we're cool? so are your sponsors!
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</span>
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<ul class="sponsors"><!--
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--><li><a href="https://uclouvain.be/en/index.html" target="_blank"><img src="https://static.igem.org/mediawiki/2017/8/87/Logo-UCL.jpg" alt="UCL"></a></li><!--
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--><li><a href="http://www.federation-wallonie-bruxelles.be/index.php?id=39" target="_blank"><img src="https://static.igem.org/mediawiki/2017/a/a1/Logo-FWB.png" alt="Fédération Wallonie Bruxelles"></a></li><!--
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--><li><a href="https://uclouvain.be/fr/chercher/fondation-louvain" target="_blank"><img src="https://static.igem.org/mediawiki/2017/3/39/Logo-Fondation_Louvain.png" alt="Fondation Louvain"></a></li><!--
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--><li><a href="https://www.neb.com/" target="_blank"><img src="https://static.igem.org/mediawiki/2017/c/cd/Logo-Imperial_College.png" alt="Imperial College"></a></li><!--
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--><li><a href="http://www.agilent.com/home" target="_blank"><img src="https://static.igem.org/mediawiki/2017/8/88/Logo-Agilent_Technologies.png" alt="Agilent Technologies"></a></li><!--
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--><li><a href="https://www.aglouvain.be/site2/" target="_blank"><img src="https://static.igem.org/mediawiki/2017/5/5d/Logo-AGL.png" alt="AGL"></a></li><!--
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--><li><a href="https://uclouvain.be/en/research-institutes/isv" target="_blank"><img src="https://static.igem.org/mediawiki/2017/1/13/Logo-ISV.png" alt="ISV"></a></li><!--
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--><li><a href="https://uclouvain.be/en/faculties/sc" target="_blank"><img src="https://static.igem.org/mediawiki/2017/0/01/Logo-UCL_Sciences.jpg" alt="UCL faculté des Sciences"></a></li><!--
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--></ul>
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</div>
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</div>
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</div>
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</section>
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<footer class="main-footer wow fadeInUp">
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<ul>
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<li><a href="#" class="animsition-link">Home</a></li>
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<li><a href="">our project</a></li>
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<li><a href="">in the lab</a></li>
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<li><a href="#" class="animsition-link">human practices</a></li>
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<li><a href="">awards</a></li>
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<li><a href="">about us</a></li>
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</div>
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</div>
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</div>
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</footer>
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                <a href="./Team:UCLouvain"><img src="https://static.igem.org/mediawiki/2017/3/3d/UCLouvain_igem_logo.png" alt="IGem UCLouvain Team"></a>
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                    <li>
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<a href="./Team:UCLouvain/OurProject">Our Project</a>
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 +
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 +
<li><a href="./Team:UCLouvain/Approach2">Approach 2</a></li>
 +
<li><a href="./Team:UCLouvain/Attributions">Attributions</a></li>
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<li><a href="./Team:UCLouvain/InterLab">InterLab</a></li>
 +
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 +
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 +
                    <li>
 +
<a href="./Team:UCLouvain/InTheLab">In The Lab</a>
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<ul>
 +
<li><a href="./Team:UCLouvain/InTheLab/Overview">Overview</a></li>
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<li><a href="./Team:UCLouvain/Protocols">Protocols</a></li>
 +
<li><a href="./Team:UCLouvain/Parts">Parts</a></li>
 +
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 +
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 +
                    <li><a href="https://2017.igem.org/Team:UCLouvain/HP/Silver">Human Practices</a></li>
 +
                    <li>
 +
<a href="./Team:UCLouvain/AboutUs">About us</a>
 +
<ul>
 +
<li><a href="./Team:UCLouvain/Team">Team</a></li>
 +
<li><a href="./Team:UCLouvain/Aknowledgement">Aknowledgement</a></li>
 +
<li><a href="./Team:UCLouvain/OurUniversity">Our University</a></li>
 +
</ul>
 +
</li>
 +
                    <li>
 +
<a href="./Team:UCLouvain/Awards">Awards</a>
 +
<ul>
 +
<li><a href="./Team:UCLouvain/Design">Design</a></li>
 +
<li><a href="./Team:UCLouvain/Model">Model</a></li>
 +
</ul>
 +
</li>
 +
                    <li><a href="https://igem.org/2017_Judging_Form?team=UCLouvain">Judging form</a></li>
 +
                </ul>
 +
            </nav>
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        </header>
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        <section id="content">
 +
            <div id="presentation">
 +
                <img src="https://static.igem.org/mediawiki/2017/8/8b/HEADER-LLN_PLAGE.png" alt="IGem UCLouvain Team">
 +
            </div>
 +
            <div id="page">
 +
<h2 class="smallclear">UCLouvain team @ iGEM 2017</h2>
 +
<h3>BactaSun: on the road for summer!</h3><!--
 +
--><div class="text">
 +
<p>Nowadays, exposition to harmful UV rays has led to an ever growing number of skin cancer cases, among other sun-related diseases. While efficient sunscreens do exist, we do not always think it necessary or forget to reapply it as often as we should. With our project called BactaSun, we propose to design a biobadge which would detect excessive UV exposure and therefore warn us to seek sun protection should it become necessary.</p>
 +
 
 +
<p>This badge would work as a capsule holding an E. Coli strain, changing colors as the UV dose and intensity increases. The capsule would also work as a safe and reliable containment, destroying the engineered microorganisms once the biobadge is discarded.</p>
 +
 
 +
<p>Starting with a tyrosine auxotroph E. coli, a gene coding for a colored protein which contains tyrosine will be constitutively expressed. Only photocaged tyrosine will be available in the media, and linked to a specific tRNA. The reporter protein will be synthetise but in the wrong conformation due to the cage presence. Once the bacterium is exposed to direct sunlight, the cage will be cleaved, inducing the good conformation of the protein and its coloration.</p>
 +
 
 +
<p>Besides the biotechnological side of this project, the design of the badge capsule itself is going to represent a great challenge. We will need to find a specific plastic which lets the UV pass trough and design a way to kill the microorganisms once the badge has been used.</p>
  
});
+
<p>Our team has also started an effort to educate the public on biotechnologies and synthetic biology. We are motivated to raise interest among scientist and others around iGEM and project like ours. The academic year 2016-2017 at UCL will unfold under the theme "Scientific Adventures". Under these circumstances, we already have been asked to lead panels and participate in debates and discussions. We hope to associate the UCLouvain iGEM project with many more initiative of this kind in the future.</p>
})(jQuery);
+
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+
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+
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+
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+
--></div>
 +
</section>
 +
<footer id="footer">
 +
<h2>Our sponsors</h2>
 +
<ul><!--
 +
--><li><a href="https://uclouvain.be/en/index.html" target="_blank"><img src="https://static.igem.org/mediawiki/2017/8/87/Logo-UCL.jpg" alt="UCL"></a></li><!--
 +
--><li><a href="http://www.federation-wallonie-bruxelles.be/index.php?id=39" target="_blank"><img src="https://static.igem.org/mediawiki/2017/a/a1/Logo-FWB.png" alt="Fédération Wallonie Bruxelles"></a></li><!--
 +
--><li><a href="https://uclouvain.be/fr/chercher/fondation-louvain" target="_blank"><img src="https://static.igem.org/mediawiki/2017/3/39/Logo-Fondation_Louvain.png" alt="Fondation Louvain"></a></li><!--
 +
--><li><a href="https://www.neb.com/" target="_blank"><img src="https://static.igem.org/mediawiki/2017/c/cd/Logo-Imperial_College.png" alt="Imperial College"></a></li><!--
 +
--><li><a href="http://www.agilent.com/home" target="_blank"><img src="https://static.igem.org/mediawiki/2017/8/88/Logo-Agilent_Technologies.png" alt="Agilent Technologies"></a></li><!--
 +
--><li><a href="https://www.aglouvain.be/site2/" target="_blank"><img src="https://static.igem.org/mediawiki/2017/5/5d/Logo-AGL.png" alt="AGL"></a></li><!--
 +
--><li><a href="https://uclouvain.be/en/research-institutes/isv" target="_blank"><img src="https://static.igem.org/mediawiki/2017/1/13/Logo-ISV.png" alt="ISV"></a></li><!--
 +
--><li><a href="https://uclouvain.be/en/faculties/sc" target="_blank"><img src="https://static.igem.org/mediawiki/2017/0/01/Logo-UCL_Sciences.jpg" alt="UCL faculté des Sciences"></a></li><!--
 +
--></ul>
 +
</footer>
 +
    </body>
 +
</html>

Revision as of 21:39, 30 October 2017

iGEM UCLouvain Team iGEM UCLouvain Team

IGem UCLouvain Team

UCLouvain team @ iGEM 2017

BactaSun: on the road for summer!

Nowadays, exposition to harmful UV rays has led to an ever growing number of skin cancer cases, among other sun-related diseases. While efficient sunscreens do exist, we do not always think it necessary or forget to reapply it as often as we should. With our project called BactaSun, we propose to design a biobadge which would detect excessive UV exposure and therefore warn us to seek sun protection should it become necessary.

This badge would work as a capsule holding an E. Coli strain, changing colors as the UV dose and intensity increases. The capsule would also work as a safe and reliable containment, destroying the engineered microorganisms once the biobadge is discarded.

Starting with a tyrosine auxotroph E. coli, a gene coding for a colored protein which contains tyrosine will be constitutively expressed. Only photocaged tyrosine will be available in the media, and linked to a specific tRNA. The reporter protein will be synthetise but in the wrong conformation due to the cage presence. Once the bacterium is exposed to direct sunlight, the cage will be cleaved, inducing the good conformation of the protein and its coloration.

Besides the biotechnological side of this project, the design of the badge capsule itself is going to represent a great challenge. We will need to find a specific plastic which lets the UV pass trough and design a way to kill the microorganisms once the badge has been used.

Our team has also started an effort to educate the public on biotechnologies and synthetic biology. We are motivated to raise interest among scientist and others around iGEM and project like ours. The academic year 2016-2017 at UCL will unfold under the theme "Scientific Adventures". Under these circumstances, we already have been asked to lead panels and participate in debates and discussions. We hope to associate the UCLouvain iGEM project with many more initiative of this kind in the future.

IGem UCLouvain Team

Our sponsors

  • UCL
  • Fédération Wallonie Bruxelles
  • Fondation Louvain
  • Imperial College
  • Agilent Technologies
  • AGL
  • ISV
  • UCL faculté des Sciences