Difference between revisions of "Team:NUS Singapore/Future Work"

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         <p>Currently we are only characterizing four different sensors as a proof of concept for our sensor library. In the future, we will be expanding the sensor library by characterizing and integrating more sensors into our tool kit so that we can develop this toolkit as a platform technology to make engineering kill switches much easier. Moreover, the current experiments focused on E.coli as a model organism and we will be expanding our characterization into Gram positive bacteria such as Lactobacillus which are used more frequently in engineered probiotics. In terms of modelling, we will be testing more modeling tools to figure out the optimal ways to construct genetic circuits for more effective killing. Since the existing models provided by CELLO usually have high metabolic stress and longer response time, we will also be exploring the possibility of simplifying the genetic circuit via a software to circumvent such shortcomings of a CELLO system.</p>
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         <p>Currently we have only characterized four different sensors as a proof of concept for our sensor library. In the future, we will be expanding the sensor library by characterizing more sensors into our toolkit so that we can develop this toolkit as a platform technology to make engineering kill switches much easier. Moreover, the current experiments focused on <i>E.coli</i> as a model organism and we will be expanding our characterization into Gram positive bacteria such as Lactobacillus which are used more frequently in engineered probiotics. In terms of modelling, we will be testing more modeling tools to figure out the optimal ways to construct genetic circuits for more effective killing. Since the existing models provided by CELLO usually have high metabolic stress and longer response time, we will also be exploring the possibility of simplifying the genetic circuit via a software to circumvent such shortcomings of a CELLO system.</p>
 
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Revision as of 13:09, 31 October 2017

Measurement Modelling Medal Check List
Team Member Attributions
Collaboration
Silver Up Gold Integrated
Overview Methodology Kill Switch for Probiotics Kill Switch for BeeT
Description Interlab Study Parts Experiment Documentation Improvement Demonstrate Safety Future Works
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Future work

Currently we have only characterized four different sensors as a proof of concept for our sensor library. In the future, we will be expanding the sensor library by characterizing more sensors into our toolkit so that we can develop this toolkit as a platform technology to make engineering kill switches much easier. Moreover, the current experiments focused on E.coli as a model organism and we will be expanding our characterization into Gram positive bacteria such as Lactobacillus which are used more frequently in engineered probiotics. In terms of modelling, we will be testing more modeling tools to figure out the optimal ways to construct genetic circuits for more effective killing. Since the existing models provided by CELLO usually have high metabolic stress and longer response time, we will also be exploring the possibility of simplifying the genetic circuit via a software to circumvent such shortcomings of a CELLO system.