Difference between revisions of "Team:BIT/Prize"

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<div class="section-upline cd-section" id="Bronze">
 
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<h1 class="title-h1"><center>Prize<center></h1>
 
<h1 class="title-h1"><center>Prize<center></h1>
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<h2 class="title-h2">Modeling</h2>
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<div class="cd-section" id="HOME">
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<h3 class="title-h3">HOME</h3>
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<p class="my-content-p">The field of synthetic biology relies heavily on mathematical models that help simulate and predict the process of biological systems. Our team established two models to simulate the process of sweeteners binding to the receptor T1R2/T1R3 and the process of sweeteners signal transduction in mating pheromone pathway. Then improve our biological systems based on the simulation results.    </p>
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<p class="my-content-p">The T1R2/T1R3 structure was built using SWISS-MODEL, then docking with the small molecule by AutoDock Vina. The signal transduction model is established by  reaction kinetics equations (RKE) and MATLAB to solve the ordinary differential equations (ODEs).  </p>
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<p class="my-content-p">We developed our models based on three main purposes:</p>
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<li class="my-content-li2">1. Determine the binding pattern between sweeteners and T1R2/T1R3. </li>
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<li class="my-content-li2">2. Establish the GPCR signal transduction model for signal measurement.</li>
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<li class="my-content-li2">3. Simulate the relationship between sweetness and red fluorescence intensity of mRFP, which was employed as a reporter.</li>
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Revision as of 18:16, 31 October 2017

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Prize

Modeling

HOME

The field of synthetic biology relies heavily on mathematical models that help simulate and predict the process of biological systems. Our team established two models to simulate the process of sweeteners binding to the receptor T1R2/T1R3 and the process of sweeteners signal transduction in mating pheromone pathway. Then improve our biological systems based on the simulation results.

The T1R2/T1R3 structure was built using SWISS-MODEL, then docking with the small molecule by AutoDock Vina. The signal transduction model is established by reaction kinetics equations (RKE) and MATLAB to solve the ordinary differential equations (ODEs).

We developed our models based on three main purposes:

  • 1. Determine the binding pattern between sweeteners and T1R2/T1R3.
  • 2. Establish the GPCR signal transduction model for signal measurement.
  • 3. Simulate the relationship between sweetness and red fluorescence intensity of mRFP, which was employed as a reporter.
    • Bronze
    Bronze

    Register for iGEM, have a great summer and attend the Giant Jamboree.

    Bronze
    Bronze

    Human Practices-silver:Thought carefully and creatively about whether our work was safe,responsible and good for the world.

    Bronze
    Bronze

    Improved the function of an existing BioBrick Part. Part number(s):K2305018 and K2305004.




    Bronze
    Bronze

    Register for iGEM, have a great summer and attend the Giant Jamboree.

    Bronze
    Bronze

    Human Practices-silver:Thought carefully and creatively about whether our work was safe,responsible and good for the world.

    Bronze
    Bronze

    Improved the function of an existing BioBrick Part. Part number(s):K2305018 and K2305004.



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