Difference between revisions of "Team:Michigan/Description"

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{{Michigan}}
 
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<h1>Description</h1>
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<p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
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<h5>What should this page contain?</h5>
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<li> A clear and concise description of your project.</li>
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<li>A detailed explanation of why your team chose to work on this particular project.</li>
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<li>References and sources to document your research.</li>
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<h5>Advice on writing your Project Description</h5>
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<h2>Project Description</h2>
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<h3>The Construct</h3>
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<h3>Temperature Control</h3>
 
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We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be consist, accurate and unambiguous in your achievements.  
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This year, Team Michigan is exploring the applications of temperature-based cellular modulation. We are engineering a temperature-controlled bacterial killswitch, designed to prevent survival of cells outside of a desired range, specifically one that is associated with typical laboratory working conditions.
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<h3>The Future of Lab Safety</h3>
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The goal is to develop a genetic switch that leverages a temperature-dependent promoter to trigger self-lysis in cells, relying on Holin and Endolysin to carry out the apoptosis. When our plasmid is implemented, bacteria will lyse itself when outside of predetermined temperature conditions. We see our construct being used as a safety measure; when working with pathogenic bacteria in a lab, it is vital to ensure the death of any bacteria that escape their controlled environment.
 
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Judges like to read your wiki and know exactly what you have achieved. This is how you should think about these sections; from the point of view of the judge evaluating you at the end of the year.
 
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<li onClick="go('/Description')"><a class="subtitle">Description</a></li>
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<li onClick="go('/Results')"><a class="subtitle">Results</a></li>
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<p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
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<h5>Inspiration</h5>
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<p>See how other teams have described and presented their projects: </p>
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<li><a href="https://2016.igem.org/Team:Imperial_College/Description">2016 Imperial College</a></li>
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<li onClick="go('')"><a class="subtitle">thermolyze</a></li>
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<li><a href="https://2016.igem.org/Team:Wageningen_UR/Description">2016 Wageningen UR</a></li>
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<li onClick="go('/Description')"><a class="subtitle">project</a></li>
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<li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> 2014 UC Davis</a></li>
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<li onClick="go('/Team')"><a class="subtitle">the team</a></li>
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<li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">2014 SYSU Software</a></li>
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<li onClick="go('/Human_Practices')"><a class="subtitle">human practices</a></li>
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<li onClick="go('/Parts')"><a class="subtitle">parts</a></li>
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<li onClick="go('/Model')"><a class="subtitle">modelling</a></li>
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<li onClick="go('/Safety')"><a class="subtitle">safety</a></li>
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<li onClick="go('/Collaborations')"><a class="subtitle">collaborations</a></li>
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<li onClick="go('/Attributions')"><a class="subtitle">attributions</a></li>
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Revision as of 11:58, 1 November 2017

MSBT 2017

Project Description

The Construct

Temperature Control

This year, Team Michigan is exploring the applications of temperature-based cellular modulation. We are engineering a temperature-controlled bacterial killswitch, designed to prevent survival of cells outside of a desired range, specifically one that is associated with typical laboratory working conditions.

The Future of Lab Safety

The goal is to develop a genetic switch that leverages a temperature-dependent promoter to trigger self-lysis in cells, relying on Holin and Endolysin to carry out the apoptosis. When our plasmid is implemented, bacteria will lyse itself when outside of predetermined temperature conditions. We see our construct being used as a safety measure; when working with pathogenic bacteria in a lab, it is vital to ensure the death of any bacteria that escape their controlled environment.