Difference between revisions of "Team:BIT/Composite Part"

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<h2>Market Analysis</h2>
 +
<p>This year, the final goal of iGEM_Bit team is to provide the potential versatility, precision, and affordability of JACOB—essentially a representation of modularized biomarker detections—to ordinary communities.
 +
Our plan is to commercialize JACOB to provide warnings for potential disease and develop a self-sustaining facility for production and further research.
 +
From market analysis, we concluded the prominent advantages of JACOB and focused on those to provide more competitive products; from direct interaction with commercial industries, we optimized JACOB's operability and compatibility with the market.
 +
</p>
 +
</div>
 +
</div>
 +
</div>
 +
</div>
 +
 +
<div class="第一段">
 +
<div class="row animate-box">
 +
<div class="col-md-8 col-md-offset-2 text-center fh5co-heading">
 +
<h2>Wireframe Connects the Underlying Conceptual Structure</h2>
 +
</div>
 +
</div>
 +
<div class="row">
 +
<div class="col-md-5 animate-box">
 +
<div class="user-frame">
 +
<h3>Wireframe Connects the Underlying Conceptual Structure</h3>
 +
<p>Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts. </p>
 +
<span>Louie Jie Mahusay</span><br>
 +
<small>CEO, Founder</small>
 +
</div>
 +
</div>
 +
<div class="col-md-7 animate-box">
 +
<p>Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts. </p>
 +
<blockquote>
 +
<p>Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts. </p>
 +
</blockquote>
 +
<p>Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts. far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts. </p>
 +
</div>
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</div>
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</div>
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<div class="column full_size">
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  <p><img src="../../2222/images/qy1.jpg" alt="Free HTML5 Bootstrap Template" class="img-responsive img-rounded"><img src="../../2222/images/qy1.jpg" alt="Free HTML5 Bootstrap Template" class="img-responsive img-rounded"></p>      
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<h1>Composite Parts</h1>
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<h2>Market Analysis</h2>
 +
 +
 
 +
 
 +
  <p>&nbsp;</p>
 +
  <p>&nbsp;</p>
 +
  <p>&nbsp;</p>
 +
<p>&nbsp;</p>
 +
<p><span class="label-warning">a. Four Aspects:</span><br>
 +
  <span class="lead">&nbsp;&nbsp;
 +
  i. Strength:
 +
  </span><br>
 +
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; 1. Convenience.
 +
  <br>
 +
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 2. Adaptability.
 +
  <br>
 +
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; 3. High Cost/Performance Ratio.<br>
 +
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;
 +
  4. Inelastic to change in test conditions.<br>
 +
  <span class="lead">&nbsp;&nbsp;
 +
  ii. Weakness:</span><br>
 +
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
  1. Technology Barrier.
 +
<br>
 +
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
  2. Branding Barrier.
 +
<br>
 +
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
  3. Strict Market Admittance Criteria.<br>
 +
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
  4. Distribution Barrier.<br>
 +
  <span class="lead">&nbsp;&nbsp;
 +
  iii. Opportunity:</span><br>
 +
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
  1. Favorable national economic condition.<br>
 +
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
  2. Positive national policies.<br>
 +
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
 +
  3. Uprising Health-consciousness.<br>
 +
  <span class="lead">&nbsp;&nbsp;
 +
  iv. Threats:</span><br>
 +
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;
 +
  1. Well-established industries control the high-end markets with related products.
 +
<br>
 +
  &nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;
 +
  2. Industrial chain is currently complete
 +
<br>
 +
  &nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;
 +
  3. Technological applications are matured</p>
 +
  <p> <span class="label-warning">b. Comments: </span><br>
 +
&nbsp;&nbsp; Comparing to technology equipped by clinics and hospitals, The use of adjustable aptamer and genetic modified microbes made JACOB more economical, adaptable, and stable. The integration of automated proceeding made JACOB more user-friendly and portable. JACOB does not need professional physicians reading results, behaving like glucose meter but less risky. In China it is likely to be deployed in units of household or local communities. Similarly, for United States the Food and Drug Administration classified the core mechanism of JACOB as Class I medical device (if designed to not detecting cancer biomarkers), means no premarketing control is required. It is worth noting though, Chinese in vitro diagnostic market is relatively new and have few competitors. Those few players can no longer support the concrete increasing demand for medical cares. Chinese government had ratified a great number of acts as well as guidelines and simplified documents examining and approval process to encourage innovation in the field of medical devices, which offers our team a great market environment. </p>
 +
<div id="fh5co-wireframe">
 +
</div>
 +
</div>
 +
</div>
 +
</div>
 +
 +
<div class="第一段">
 +
<div class="row animate-box">
 +
<div class="col-md-8 col-md-offset-2 text-center fh5co-heading">
 +
<h2>Wireframe Connects the Underlying Conceptual Structure</h2><p>In market analysis we had solved many issues regarding our project background, but also generated more questions about operability. To obtain a better answer, we had visited 北京永翰星港生物技术有限公司和博奥生物芯片公司. </p>
 +
</div>
 +
</div>
 +
<div class="row">
 +
<div class="col-md-5 animate-box">
 +
<div class="user-frame">
 +
<h3></h3>
 +
<p>We asked 蓝晶 mainly on how to construct a viable procedure to industrialize JACOB. Our plan for JACOB after the iGEM jamboree is divided into developments, commercialization, and resource transformation. For development we currently divided it into small, medium, large scale trial. Based on our current knowledge, small and medium trial is planned as below  </p>
 +
<span>Louie Jie Mahusay</span><br>
 +
<small>CEO, Founder</small>
 +
</div>
 +
</div>
 +
<div class="col-md-7 animate-box">
 +
<p>Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts. </p>
 +
<blockquote>
 +
<p>Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts. </p>
 +
</blockquote>
 +
<p><span class="label-warning">1. Small Scale Trial</span><br>
 +
                    &nbsp;&nbsp;&nbsp; a. Duration: About half year
 +
                      <br>
 +
                    &nbsp;&nbsp;&nbsp; b. We will choose the production method for JACOB, e.g. as we learned from 永翰星港, the "filtration" of aptamers are still expensive, but aptamers synthesis is more economical. Nine sets of known aptamer (90np, 15 microliter, 100nmol/L) costs only about $135, and every set is sufficient for 250 microfluidic chips.<br>
 +
                    &nbsp;&nbsp;&nbsp;
 +
c. During this phase we also need to rule out unknown influences on the device caused by switching to new assembly conditions, such as switching to fermentation flask instead of tightly controlled experiment chamber.
 +
<br>
 +
&nbsp;&nbsp;&nbsp;
 +
d. During this phase preserving microbes will greatly affect the cost of production, and affordability is one of the most important characteristics of JACOB.<br>
 +
<span class="label-warning">2. Medium Scale Trial</span><br>
 +
&nbsp;&nbsp;&nbsp;
 +
a. Duration: 4-5 months<br>
 +
&nbsp;&nbsp;&nbsp;
 +
b. When the production of microfluidic chip is resolved, how to prepare it for using will be on the agenda. Currently the chip we used for final packaging needs to be soaked in ethyl alcohol and acetone for about one hour, which pose a question for mass production. </p>
 +
</div>
 +
<p>We asked 博奥 mainly on how to control the cost of microfluidic chip production¬. From their experience we found that chips cost much more in the early development, but its cost diminishes quickly in later stages when mass production is reached, ranging from $0.1 to few dollars. However, there exist a conflict of material. In the iGEM version we picked optical cement instead of PMDS for its advantages of adequate solidification speed, feasibility, bio-inertia, and precision of altitude. However, PMDS production industries are much more matured. There is currently no companies offering mass production of optical cement microfluidic chips. Thus, we must decide the better material.</p>
 +
</div>
 +
</div>
 +
</div>
 +
</div>
  
−
<p>
 
−
A composite part is a functional unit of DNA consisting of two or more basic parts assembled together. <a href="http://parts.igem.org/wiki/index.php/Part:BBa_I13507">BBa_I13507</a> is an example of a composite part, consisting of an RBS, a protein coding region for a red fluorescent protein, and a terminator.
 
−
</p>
 
  
−
<p>New composite BioBrick devices can be made by combining existing BioBrick Parts (like Inverters, Amplifiers, Smell Generators, Protein Balloon Generators, Senders, Receivers, Actuators, and so on).</p>
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<p>New BioBrick devices can be made by combining existing BioBrick Parts. For example, Inverters, Amplifiers, Smell Generators, Protein Balloon Generators, Senders, Receivers, Actuators, and so on. To be eligible for this award, this part must adhere to <a href="http://parts.igem.org/DNA_Submission">Registry sample submission guidelines</a> and have been sent to the Registry of Standard Biological Parts. If you have a part you wish to nominate your team for this <a href="https://2017.igem.org/Judging/Awards">special prize</a>, make sure you add your part number to your <a href="https://2017.igem.org/Judging/Judging_Form">judging form</a> and delete the box at the top of this page.
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<b>Please note:</b> Judges will only look at the first part number you list, so please only enter ONE (1) part number in the judging form for this prize. </p>
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<h4>Contact Information</h4>
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<p>This page should list all the composite parts your team has made during your project. You must add all characterization information for your parts on the Registry. You should not put characterization information on this page. Remember judges will only look at the first part in the list for the Best Composite Part award, so put your best part first!</p>
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Revision as of 19:23, 1 November 2017

Market Analysis

This year, the final goal of iGEM_Bit team is to provide the potential versatility, precision, and affordability of JACOB—essentially a representation of modularized biomarker detections—to ordinary communities. Our plan is to commercialize JACOB to provide warnings for potential disease and develop a self-sustaining facility for production and further research. From market analysis, we concluded the prominent advantages of JACOB and focused on those to provide more competitive products; from direct interaction with commercial industries, we optimized JACOB's operability and compatibility with the market.

Wireframe Connects the Underlying Conceptual Structure

Wireframe Connects the Underlying Conceptual Structure

Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts.

Louie Jie Mahusay
CEO, Founder

Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts.

Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts.

Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts. far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts.

Free HTML5 Bootstrap TemplateFree HTML5 Bootstrap Template

Market Analysis

 

 

 

 

a. Four Aspects:
   i. Strength:
         1. Convenience.
         2. Adaptability.
         3. High Cost/Performance Ratio.
         4. Inelastic to change in test conditions.
   ii. Weakness:
         1. Technology Barrier.
         2. Branding Barrier.
         3. Strict Market Admittance Criteria.
         4. Distribution Barrier.
   iii. Opportunity:
         1. Favorable national economic condition.
         2. Positive national policies.
         3. Uprising Health-consciousness.
   iv. Threats:
        1. Well-established industries control the high-end markets with related products.
        2. Industrial chain is currently complete
        3. Technological applications are matured

b. Comments:
   Comparing to technology equipped by clinics and hospitals, The use of adjustable aptamer and genetic modified microbes made JACOB more economical, adaptable, and stable. The integration of automated proceeding made JACOB more user-friendly and portable. JACOB does not need professional physicians reading results, behaving like glucose meter but less risky. In China it is likely to be deployed in units of household or local communities. Similarly, for United States the Food and Drug Administration classified the core mechanism of JACOB as Class I medical device (if designed to not detecting cancer biomarkers), means no premarketing control is required. It is worth noting though, Chinese in vitro diagnostic market is relatively new and have few competitors. Those few players can no longer support the concrete increasing demand for medical cares. Chinese government had ratified a great number of acts as well as guidelines and simplified documents examining and approval process to encourage innovation in the field of medical devices, which offers our team a great market environment.

Wireframe Connects the Underlying Conceptual Structure

In market analysis we had solved many issues regarding our project background, but also generated more questions about operability. To obtain a better answer, we had visited 北京永翰星港生物技术有限公司和博奥生物芯片公司.

We asked 蓝晶 mainly on how to construct a viable procedure to industrialize JACOB. Our plan for JACOB after the iGEM jamboree is divided into developments, commercialization, and resource transformation. For development we currently divided it into small, medium, large scale trial. Based on our current knowledge, small and medium trial is planned as below

Louie Jie Mahusay
CEO, Founder

Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts.

Far far away, behind the word mountains, far from the countries Vokalia and Consonantia, there live the blind texts far from the countries Vokalia and Consonantia, there live the blind texts.

1. Small Scale Trial
    a. Duration: About half year
    b. We will choose the production method for JACOB, e.g. as we learned from 永翰星港, the "filtration" of aptamers are still expensive, but aptamers synthesis is more economical. Nine sets of known aptamer (90np, 15 microliter, 100nmol/L) costs only about $135, and every set is sufficient for 250 microfluidic chips.
    c. During this phase we also need to rule out unknown influences on the device caused by switching to new assembly conditions, such as switching to fermentation flask instead of tightly controlled experiment chamber.
    d. During this phase preserving microbes will greatly affect the cost of production, and affordability is one of the most important characteristics of JACOB.
2. Medium Scale Trial
    a. Duration: 4-5 months
    b. When the production of microfluidic chip is resolved, how to prepare it for using will be on the agenda. Currently the chip we used for final packaging needs to be soaked in ethyl alcohol and acetone for about one hour, which pose a question for mass production.

We asked 博奥 mainly on how to control the cost of microfluidic chip production¬. From their experience we found that chips cost much more in the early development, but its cost diminishes quickly in later stages when mass production is reached, ranging from $0.1 to few dollars. However, there exist a conflict of material. In the iGEM version we picked optical cement instead of PMDS for its advantages of adequate solidification speed, feasibility, bio-inertia, and precision of altitude. However, PMDS production industries are much more matured. There is currently no companies offering mass production of optical cement microfluidic chips. Thus, we must decide the better material.

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