<h3 class="textcenter"> Editing the Human Microbiome: Preventing Aerosolized Peptide Proteins </h3>
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<h3 class="textcenter"> MEW line: Mucosal Early Warning system </h3>
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<h3> In The Beginning... <h3>
<h3> In The Beginning... <h3>
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<h4> This is where we can talk about how the beginnings of the project started, the crew that was involved, and all of that jazz. Include hyperlinks here when names are mentioned, that would be a cool little feature for our website. Also, we can include hyperlinks to part of our interlab if it has any kind of relation. Also, we can change the background photo here from the DNA strand thing to something a little different like a series of pipes or something.</h4><br>
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<h4> We followed the classic theme of design, build, test, model and repeat in the field of synthetic biology. Before starting our project, we first sat down and thought about what our focus for this years project would be. Since we were continuing our project from last year, we did some more research on the respiratory microbiome and Sodium Channels. And for those of you who are unfamiliar with what a microbiome is, a microbiome is community of commensal and symbiotic microorganisms found in all multicellular organisms. These bacteria live among plants and animals and are crucial for immunologic, hormonal and metabolic homeostasis of their host. In order to redesign the construct, we needed to find a less complicated sense and response system than the Arc system, which we used last year.
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<h4> This is just some extra space that happens to be around if we need to use it. </h4> <br>
We followed the classic theme of design, build, test, model and repeat in the field of synthetic biology. Before starting our project, we first sat down and thought about what our focus for this years project would be. Since we were continuing our project from last year, we did some more research on the respiratory microbiome and Sodium Channels. And for those of you who are unfamiliar with what a microbiome is, a microbiome is community of commensal and symbiotic microorganisms found in all multicellular organisms. These bacteria live among plants and animals and are crucial for immunologic, hormonal and metabolic homeostasis of their host. In order to redesign the construct, we needed to find a less complicated sense and response system than the Arc system, which we used last year.
Applications
The protein within the plasmid backbone of bacteria natural to the human microbiome could be used as a therapeutic drug to protect people from possible toxicants in the environment by sensing their harmful effects within biofilms and host cells or as a therapeutic drug to enhance someone’s natural microbiome by beneficial ionic responses with biofilm formation. For example, it could be taken and used to coat the insides of the respiratory tract to detect changes and prevent unregulated ion channels. This in turn could prevent serious bodily harm with minimal disturbance of ion balance/ biofilms and could enhance microbiome response overall.
Protective biofilms throughout your body
Bacteria communicate with each other and the host cells
Create a sensor for ions for cell to cell communications in a medically relevant way
Out on the battlefield and expect to be exposed
What’s the response from the respiratory tract
Cell-cell communication within biofilms and with the host using ions within the human body
Risks
Our modified organism could pose the risk of environmental release, if applied to the human body. We will need to engineer in a kill-switch mechanism, or another self-destruct mechanism to control unintended proliferation.
