Difference between revisions of "Team:JNFLS/Description"

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<h1>Description</h1>
 
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<p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
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<p>Colon cancer is the second most common cancer in China. It happens when tumorous growths develop in the large intestine. The mortality rate of early stage is lower than 5%. Unfortunately, the clinical manifestation of early stage is not obvious and lacks specificity which makes colon cancer easily treated as appendicitis or enteritis. As a result, most patients are diagnosed with advanced tumor, whose mortality rate is over 95%. What’s worse, low success rate and unbearable pain discourage a large proportion of sufferers to receive conventional treatments including surgeries, radiotherapy and chemotherapy, which further lowers the possibility of survival. Consequently, the major reason why we concern particularly colon cancer is that colon cancer is considered as one of the most fatal assassin of health as well as life quality, especially to middle-aged people in China and the world.</p>
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<p>As a daily beverage and inexpensive healthy product, yogurt is bought and drunk extensively in our daily life, which makes it a desirable medium to carry the designed probiotics across the digestive system to where the colon tumor locates.</p>
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<h5>What should this page contain?</h5>
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<img class="small" src="https://static.igem.org/mediawiki/2017/9/99/JNFLS-Description-2.png" />
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<li> A clear and concise description of your project.</li>
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<img class="small" src="https://static.igem.org/mediawiki/2017/d/d2/JNFLS-Description-3.png" />
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<li>A detailed explanation of why your team chose to work on this particular project.</li>
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<li>References and sources to document your research.</li>
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<li>Use illustrations and other visual resources to explain your project.</li>
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<p>Theoretically, the biggest characteristic of cancer cells is rapid cell division, resulting in the hypoxia microenvironment of solid tumor. Our project is to construct three plasmids, which are transported to the solid tumor using the probiotics Nissle 1917 as gene delivery carrier. To be more specific, when the extracellular environment lacks oxygen, a plasmid in Nissle 1917 can express invasion protein and HylA protein, allowing the Nisssle 1917 to invade into tumor cells and avoid cell lysosomes endocytosis. After the Nissle 1917 enters solid tumor cells, the second plasmid will express TAT protein, inducing cell apoptosis. The specialty of our project is that if the Nissle 1917 enters the nontumorous cells by mistake, the third plasmid will initiate suicide program, which will not pose a threat to normal cells, achieving the security of gene therapy.</p>
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<h5>Advice on writing your Project Description</h5>
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We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be consist, accurate and unambiguous in your achievements.
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Judges like to read your wiki and know exactly what you have achieved. This is how you should think about these sections; from the point of view of the judge evaluating you at the end of the year.
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<h5>References</h5>
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<p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p>
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<h5>Inspiration</h5>
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<p>See how other teams have described and presented their projects: </p>
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<li><a href="https://2016.igem.org/Team:Imperial_College/Description">2016 Imperial College</a></li>
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<li><a href="https://2016.igem.org/Team:Wageningen_UR/Description">2016 Wageningen UR</a></li>
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<li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> 2014 UC Davis</a></li>
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<li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">2014 SYSU Software</a></li>
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Latest revision as of 20:30, 1 March 2018

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JNFLS

Description

Tell us about your project, describe what moves you and why this is something important for your team.

What should this page contain?
  • A clear and concise description of your project.
  • A detailed explanation of why your team chose to work on this particular project.
  • References and sources to document your research.
  • Use illustrations and other visual resources to explain your project.
Advice on writing your Project Description

We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be consist, accurate and unambiguous in your achievements.

Judges like to read your wiki and know exactly what you have achieved. This is how you should think about these sections; from the point of view of the judge evaluating you at the end of the year.

References

iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.

Inspiration

See how other teams have described and presented their projects: