Difference between revisions of "Team:BGIC-Union"

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                            <h2 class="hero-heading">dCasKnight</h2>
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                            <p class="lead">A paired dCas9-T7 coupled biosensor </p>
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                            <a href="#" class="btn btn-lg hero-button">LEARN MORE</a>
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                            <h2 class="hero-heading">From Shenzhen BGIC with Love</h2>
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                            <p class="lead">A united team with members from eight cities</p>
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                            <a href="#" class="btn btn-lg hero-button">KNOW US</a>
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                            <p class="lead2">We learn about cancer diagonosis, bio-containment and more</p>
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<p>
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Cancer is one of the most deadly diseases in the world. Cancer accounts for more than 8.8 million deaths in 2015. Lung cancer, one of the top five cancers, took away 1.69 million lives in 2015. Although medicine and cancer treatments have been highly developed overtime, it is still difficult to diagnose and cure lung cancer in its early stage, particularly for non-small cell lung cancer (NSCLC).
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Our main task is to construct a test paper that contains a powerful biosensor capable of detecting any DNA sequence. The biosensor, which is composed by dcas9 and T7 polymerase coupled system, can act like a smart automatic switch. When the test paper detects a particular DNA sequence, it then releases a visible signal.
  
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$(".menu_button").click(function(){
 
 
// add or remove the class "open" , this class holds the
 
 
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$(this).children().toggleClass("open");
 
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// call the current page highlight function
 
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evaluated */
 
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border: 4px solid #3399ff;
 
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</style>
 
 
 
<!--- THIS IS WHERE THE HTML BEGINS --->
 
 
 
 
 
 
 
 
<div class="igem_2017_menu_wrapper" >
 
 
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION">
 
<img
 
 
src="https://static.igem.org/mediawiki/2017/2/29/Back_bgic.jpeg">
 
</a>
 
 
 
<!-- this div is hidden by default and will only be displayed if the screen size is
 
 
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<div class="menu_button" id="display_menu_control">
 
MENU 
 
</div>
 
 
<div id="menu_content">
 
 
 
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION">
 
<div class="menu_button direct_to_page">
 
HOME
 
</div>
 
</a>
 
 
 
 
<div class="menu_button">
 
<div class="expand_collapse_icon">  </div> TEAM
 
</div>
 
 
<div class="submenu_wrapper" id="team_submenu">
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Team">
 
<div class="submenu_button" id="Team_page">
 
Team
 
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<div class="submenu_button"  id="Collaborations_page">
 
Collaborations
 
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<div class="menu_button">
 
<div class="expand_collapse_icon">  </div> PROJECT
 
</div>
 
 
<!-- project submenu -->
 
<div class="submenu_wrapper">
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Description">
 
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Description
 
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<a href="https://2017.igem.org/Team:BGIC-UNION/Design">
 
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Design
 
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<a href="https://2017.igem.org/Team:BGIC-UNION/Experiments">
 
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Experiments
 
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</a>
 
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Notebook">
 
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Notebook
 
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</a>
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/InterLab">
 
<div class="submenu_button"  id="InterLab_page">
 
InterLab
 
</div>
 
</a>
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Contribution">
 
<div class="submenu_button"  id="Contribution_page">
 
Contribution
 
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</a>
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Model">
 
<div class="submenu_button"  id="Model_page">
 
Model
 
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</a>
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Results">
 
<div class="submenu_button"  id="Results_page">
 
Results
 
</div>
 
</a>
 
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Demonstrate">
 
<div class="submenu_button"  id="Demonstrate_page">
 
Demonstrate
 
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</a>
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Improve">
 
<div class="submenu_button"  id="Improve_page">
 
Improve
 
</div>
 
</a>
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Attributions">
 
<div class="submenu_button"  id="Attributions_page">
 
Attributions
 
</div>
 
</a>
 
 
</div>
 
 
 
 
 
 
 
<div class="menu_button">
 
<div class="expand_collapse_icon">  </div> PARTS
 
</div>
 
 
<!-- parts submenu -->
 
<div class="submenu_wrapper">
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Parts">
 
<div class="submenu_button"  id="Parts_page">
 
Parts
 
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<a href="https://2017.igem.org/Team:BGIC-UNION/Basic_Part">
 
<div class="submenu_button"  id="Basic_Part_page">
 
Basic Parts
 
</div>
 
</a>
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Composite_Part">
 
<div class="submenu_button"  id="Composite_Part_page">
 
Composite Parts
 
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</a>
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Part_Collection">
 
<div class="submenu_button"  id="Part_Collection_page">
 
Part Collection
 
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</div>
 
 
 
 
 
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Safety">
 
<div class="menu_button direct_to_page">
 
SAFETY
 
</div>
 
</a>
 
 
 
 
 
 
 
 
<div class="menu_button" >
 
<div class="expand_collapse_icon">  </div> HUMAN PRACTICES
 
</div>
 
 
<!-- human practices submenu -->
 
<div class="submenu_wrapper">
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/HP/Silver">
 
<div class="submenu_button"  id="Silver_page">
 
Silver HP
 
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</a>
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/HP/Gold_Integrated">
 
<div class="submenu_button" id="Gold_Integrated_page">
 
Integrated and Gold
 
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<a href="https://2017.igem.org/Team:BGIC-UNION/Engagement">
 
<div class="submenu_button"  id="Engagement_page">
 
Public Engagement
 
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<div class="menu_button">
 
<div class="expand_collapse_icon">  </div> AWARDS
 
</div>
 
 
<!-- awards submenu -->
 
<div class="submenu_wrapper">
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Applied_Design">
 
<div class="submenu_button"  id="Applied_Design_page">
 
Applied Design
 
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</a>
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Entrepreneurship">
 
<div class="submenu_button"  id="Entrepreneurship_page">
 
Entrepreneurship
 
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</a>
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Hardware">
 
<div class="submenu_button"  id="Hardware_page">
 
Hardware
 
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</a>
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Measurement">
 
<div class="submenu_button"  id="Measurement_page">
 
Measurement
 
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<a href="https://2017.igem.org/Team:BGIC-UNION/Model">
 
<div class="submenu_button"  id="Model_page">
 
Model
 
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</a>
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Plant">
 
<div class="submenu_button"  id="Plant_page">
 
Plant
 
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</a>
 
 
 
<a href="https://2017.igem.org/Team:BGIC-UNION/Software">
 
<div class="submenu_button"  id="Software_page">
 
Software
 
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<a href="https://igem.org/2017_Judging_Form?team=BGIC-UNION">
 
<div class="menu_button direct_to_page">
 
JUDGING FORM
 
</div>
 
</a>
 
 
 
 
<div class="menu_bottom_padding" >
 
</div>
 
 
</div>
 
 
 
 
 
</div>
 
 
 
 
<!-- start of content -->
 
<div class="igem_2017_content_wrapper">
 
<h1>BGIC-UNION</h1>
 
 
 
 
<div class="column full_size" >
 
<img src="https://static.igem.org/mediawiki/2017/2/29/Back_bgic.jpeg">
 
</div>
 
 
 
 
 
 
 
 
<div class="column full_size" >
 
<h1> dCasKnight </h1>
 
<p></p>
 
<h2> Description </h2>
 
<p align="justify">
 
Cancer is one of the most deadly diseases in the world. Cancer accounts for more than 8.8 million deaths in 2015. Lung cancer, one of the top five cancers, took away 1.69 million lives in 2015. Although medicine and cancer treatments have been highly developed overtime, it is still difficult to diagnose and cure lung cancer in its early stage, particularly for non-small cell lung cancer (NSCLC).
 
<br>
 
Our main task is to construct a test paper that contains a powerful biosensor capable of detecting any DNA sequence. The biosensor, which is composed by dcas9 and T7 polymerase coupled system, can act like a smart automatic switch. When the test paper detects a particular DNA sequence, it then releases a visible signal.
 
<br>
 
 
For diagnosing NSCLC cancer, we will use our biosensor to detect the fusion gene EML4-ALK, which is thought to have huge connections with lung cancer. The formation of this protein has to do with the alteration that occurred in the chromosomes. The alteration means one small piece of chromosome mysteriously going to the tail of another chromosome. If we are able to use our dcas9 and T7 polymerase coupled system to find EML4-ALK effectively and identify it at an early stage, then we will be creating a faster and safer cancer diagnostic process and immensely help people in pain with NSCLC cancer or even other types of cancers.  
 
For diagnosing NSCLC cancer, we will use our biosensor to detect the fusion gene EML4-ALK, which is thought to have huge connections with lung cancer. The formation of this protein has to do with the alteration that occurred in the chromosomes. The alteration means one small piece of chromosome mysteriously going to the tail of another chromosome. If we are able to use our dcas9 and T7 polymerase coupled system to find EML4-ALK effectively and identify it at an early stage, then we will be creating a faster and safer cancer diagnostic process and immensely help people in pain with NSCLC cancer or even other types of cancers.  
  
 
+
</p>
<br>
+
                    </div>
We have another envision as well: enabling our biosensor to spot potentially dangerous experimental  cells and initiate cell self-killing process when the cells escape its original habitat. This could build a much safer experimental environment. Our detection system is promising because through designing different target sequences for the biosensor it can be applied to detection of many other types of cancers or genetic diseases.
+
                    <div class="col-md-6">
</p>
+
                        <img src="assets/img/intro-img.png" class="img-responsive" alt="Image Intro">
</div>  
+
                    </div>
 
+
<div class="clear"></div>
+
 
+
<div class="column full_size" >
+
<h5> More recent study facts about lung cancer </h5>
+
<p>There were experiments done in support of the relationship between the protein EML4-ALK with small cell lung cancer (SCLC) or non-small cell lung cancer (NSLC). Many experiments used real-time PCR and screening to detect the existence of the protein in the samples. An experiment discovered that the isoforms of the protein EML4-ALK has direct connections with NSCLC, which was found in two patients (1). There were also other evidences tested from reverse transcription PCR screening that endorsed the idea of strong associations between EML4-ALK with SCLC or NSLC (2). One of the existing remedies for this kind of lung cancer is Alectinib. It is an oral drug that block ALK activities and applied as one of the most recent targeted therapies that aim at the EML4-ALK fusion gene.
+
<br>
+
 
+
(1) The results are from Identification of Novel Isoforms of the EML4-ALK Transforming Gene in Non–Small Cell Lung Cancer published at July 1st, 2008.
+
<br>
+
(2) Results found in Multiplex Reverse Transcription-PCR Screening for EML4-ALK Fusion Transcripts published October 15, 2008.
+
</p>
+
 
+
</div>
+
 
+
 
+
 
+
 
+
<div class="column half_size" >
+
<h5> Team </h5>
+
<p>The BGIC-Union is founded under BGI (The Beijing Genomics Institute). Our team consists of 12 Chinese students from different cities in China, UK and USA. The twelve students are divided into three groups: Experiment, Theory, and Marketing. Each team works with the guidance of an advisor and a group leader.</p>
+
 
+
 
+
 
+
</div>
+
 
+
<div class="column half_size" >
+
<h5> What's next </h5>
+
<p>From June to August, all the members will come together and complete most of the experiments, which is one of the most crucial parts of our project. At the same time, we will also begin to work on human practices, which is to “go beyond the lab”, and extend our project into a social context. We will explore our project’s relation with ethical, social, economic and bio-safety issues and bring it to the next level. Lectures and events, which are based on our project, will be delivered in schools or in public. We will raise public awareness on lung cancer, synthetic biology and precision medical treatment.
+
 
+
In November, BGIC-Union will fly across half of the world and take part in the Giant Jamboree in MIT to present our project. In the long term, we hope our project can go further, spark new thoughts in genetic engineering and inspire more young people to do more research!
+
 
+
</p>
+
 
+
 
+
 
+
</div>
+
 
+
<p>&nbsp;</p>
+
  </p>
+
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Revision as of 14:20, 26 July 2017

<!DOCTYPE html> Team:BGIC-Union

IMPROVED DESIGN

SOCIAL OUTREACH

NEW APPLICATION

EFFCTIVE COLLABORATION

DESCRIPTION

Cancer is one of the most deadly diseases in the world. Cancer accounts for more than 8.8 million deaths in 2015. Lung cancer, one of the top five cancers, took away 1.69 million lives in 2015. Although medicine and cancer treatments have been highly developed overtime, it is still difficult to diagnose and cure lung cancer in its early stage, particularly for non-small cell lung cancer (NSCLC).

Our main task is to construct a test paper that contains a powerful biosensor capable of detecting any DNA sequence. The biosensor, which is composed by dcas9 and T7 polymerase coupled system, can act like a smart automatic switch. When the test paper detects a particular DNA sequence, it then releases a visible signal. For diagnosing NSCLC cancer, we will use our biosensor to detect the fusion gene EML4-ALK, which is thought to have huge connections with lung cancer. The formation of this protein has to do with the alteration that occurred in the chromosomes. The alteration means one small piece of chromosome mysteriously going to the tail of another chromosome. If we are able to use our dcas9 and T7 polymerase coupled system to find EML4-ALK effectively and identify it at an early stage, then we will be creating a faster and safer cancer diagnostic process and immensely help people in pain with NSCLC cancer or even other types of cancers.

Image Intro

IMPROVED DESIGN

Based on...we improved

SOCIAL OUTREACH

We held...

NEW APPLICATION

Our design can be applied to ...

EFFCTIVE COLLABORATION

We have discussions with....

DEMONSTRATION

Ultra Responsive

DETECTION

dCas9 sgRNA

Easy to Customize

SIGNALING

FLUC

Clean and Elegant Design

ANALYSIS

DATA

Free Updates and Support

TREATMENT

treatment