Difference between revisions of "Team:DTU-Denmark/TeamMembers"

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      <p>Envenomation by snakebite is one of the most neglected diseases with an estimated 5 million bites. These result in about 100,000 deaths and 400,000 disabilities annually [1]. The only effective treatment is animal derived antivenoms, which frequently causes adverse reactions [2]. As a result they are often only administered as a last resort.</p>
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<p>One of the major problems related to treatment of snake bites concerns the lack of identification of the snake. When bitten, it is difficult for most people to remember details about the snake, which makes it almost impossible to confidently administer the correct specific antivenom. Currently, if the snake cannot be identified, multispecies antivenom is used in a consequently higher dose leading to more severe side effects. By solving the venom identification problem it could potentially increase the survival rate of snake bite victims. This is due to decreased diagnosis time and less amount of antivenom necessary for treatment, thereby causing fewer adverse reactions in the patient [3].</p>
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<h2>Gijs Verkleij </h2>
<p>We aim to create a novel diagnostic platform by using synthetic biology derived protease activity assay to identify specific venom enzymes that, by developing suitable substrates, can investigate the relative composition of specific venom components in a blood sample. Our goal is to create a diagnostic tool that would make it possible for a clinician to quickly determine which antivenom is necessary, or if it is necessary at all.</p><br /><br />
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<p><font size="1">References:<br /><br />
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<p>MSc. Biotechnology, 3rd semester.
[1] Chippaux JP (1998). <em>Snake-bites: appraisal of the global situation.</em> Bulletin of the World Health Organization, 76(5),515-24.<br />
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What is your motivation for joining the iGEM team?
[2] Gutiérrez JM, León G, Lomonte B, Angulo Y (2011). <em>Antivenoms for Snakebite Envenomings. Inflammation and Allergy.</em> Drug Targets 10(5), 369–80.<br />
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[3] Warrell D, Gutierrez JM, Padilla A (2007). <em>Rabies and Envenomings: a Neglected Public Health Issue: Report of a Consultative Meeting.</em> World Health Organization, Geneva.</font></p>
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Synthetic biologists are the next rockstars! Not just me who’s saying that, according to wired.com: "biologists are the next rock star designers"
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Theater or cinema?
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Cinema, because it’s for young people. I will engineer my own genes to stay forever young.
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What did you work on during the project?
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I worked very hard in the lab during the summer, designing and executing the CRISPR strategy for the insertion of the URA3 gene. I helped plan and host a lecture during our BioBrick tutorial, and helped supervising the high-school students in the lab.
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Revision as of 11:50, 10 August 2017

Team members

Gijs Verkleij

MSc. Biotechnology, 3rd semester. What is your motivation for joining the iGEM team? Synthetic biologists are the next rockstars! Not just me who’s saying that, according to wired.com: "biologists are the next rock star designers" Theater or cinema? Cinema, because it’s for young people. I will engineer my own genes to stay forever young. What did you work on during the project? I worked very hard in the lab during the summer, designing and executing the CRISPR strategy for the insertion of the URA3 gene. I helped plan and host a lecture during our BioBrick tutorial, and helped supervising the high-school students in the lab.

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