Team:INSA-UPS France/test/description
Description
Combine to improve: a synthetic biology scale-up
Nature offers us a wide variety of tools in order to sense precise chemical or physical parameters. For example, enzymes and receptors are specialized for unique or restrained range of molecule, or even for specific light wavelength.1,2,3 Obviously, as mankind progressed in the comprehension of life science, he wanted to take advantage from this extreme diversity and specialization. Synthetic biology was born thanks to those expectations in the early of the twentieth century4 and made quite notable breakthrough. However, most of those works were based on the insertion of a lot of DNA information on one single model, typically E. coli. We observed that all those informations are not always compatible with the use of a unique microbial chassis : although standard microbial models are quite modular, they have a particular membrane, specific pathways and different ways to do protein maturation.
Why should we persist to use a single model when we have access to a wide diversity of organisms?
For our iGEM project, we decided to focus on the multi organisms aspect, making communication between prokaryotic and eukaryotic possible.
