Team:Aix-Marseille/DEPS

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EPS Depolymerase

To combat the problem that is Xylella fastidiosa we firstly started searching for natural solutions against this bacterium and surely, we found bacteriophages that loved destroying this bacterium.

In our researcher, a modified phage would not be possible because of restriction in spreading modified organism able to replicate in the wild. Therefore, a non-lytic and non-lysogenic phage was born using fibrous phage M13 with a modification of its genome in the objective of being modular and flexible to use against varies pathogens.

The phages against Xylella fastidiosa have a devious way to infect the bacterium by cleaving the sugar bond in the biofilm then link on the receptors pili type IV on the membrane that will sets off a series of action leading to the injection of the bacteriophage genome in the bacterium triggering the life cycle of the phage.