Team:TokyoTech/Medal
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Achievements
Medal Criteria
| Bronze | Register and attend | We registered for iGEM, had a great summer, and attended the Giant Jamboree. |
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| Deliverables | We met all deliverables on the Requirements page. |
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| Attribution | We created a page on our team wiki with clear attribution of each aspect of our project. |
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| Part | We documented 5 new BioBrick Parts (BBa_K1949100, BBa_K1949101, BBa_K1949102, BBa_K1949000, BBa_K1949001) central to our project and submitted them to the iGEM Registry . |
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| Silver | Validated Part | We experimentally validated and documented 4 new BioBrick Parts/Devices (BBa_K1949050, BBa_K1949052, BBa_K1949030, BBa_K1949032) of our own design and construction that work as expected. |
| Collaboration | We helped team KAIT_Japan model their system and taught a new high school team ASIJ about modeling. |
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| Human Practices | We considered our project from three aspects: education, ethics, and economy. To achieve this, we have done various outreach activities: School-visits, creating videos and a card game, hosting a symposium of bioethics, developing our original ethics code, and creating devices of protein production control. We also designed some genetic circuits which recreate other versions of Sow White. Through these activities, we could communicate with the public and improve our project from their feedback. |
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| Gold | Integrated Human Practices | We held many activities in respect to our three aspects: education, ethics and economy. For example, we gave lessons to the students at 6 different high schools (269 students in total) and held a symposium. In addition, we applied the advice and ideas we got from the students and experts into our project. As a result, our Wet lab and Dry lab integrated to make "ACADwarfs," as well as figure out the concept of "TA system ～the Queen's Caprice～." |
| Improvement / Characterization | We correctly improved a BioBrick Parts (BBa_R0071) and characterized 6 BioBrick Parts/Device (BBa_C0071, BBa_C0171, BBa_K1529300, Bba_K1529310, BBa_K1096002, BBa_K1096001) |
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| Proof of concept | We demonstrated 4 functional proof of concept of our project: New cold inducible promoter, Rhl system assay, TA system, Degradation of C12 by AmiE. |
Best Information Processing
これまでのiGEMでは細菌同士の情報処理は盛んに行われてきた。今年我々はヒト細胞という細菌より複雑で、増殖速度などが細菌と大きく異なる細胞を対象にした。さらに両者を共培養することで、増殖速度や物質生産速度が大きく異なる細胞集団同士の情報処理に挑戦した。複雑系において重要な要素を選び出してモデルを抽象化し、シミュレーションした。結果、大腸菌数をヒト細胞によって制御し得ることや、共存可能なヒト細胞数と細菌数の関係を明らかにした。私たちはヒト細胞と大腸菌を共存させた新しい生命システムの構築（engineering）に成功した。これはiGEMの新たな一歩になると考えている。
Proof of Concept
今回用いた2つの融合シグナル伝達系によって、ヒト細胞と大腸菌のシグナル伝達を可能にした。これによって、細菌とほ乳類という界を超えたコミュニケーションが可能になり、iGEMの新しいstandardになると考えられる。
Discussion
考察
Reference
参考文献
Hajime Fujita: All Rights Reserved
