Team:ETH Zurich/Experiments/Heat Sensor
Tumor Sensor Experiments
Introduction
We incorporated a module into our system that would allow our engineered bacteria to sense the toxin release signal of the doctor, mediated by a temperature increase to 45 °C. For this, we needed to fit a naturally occurring heat sensor from Salmonella into our novel genetic circuit. If the heat sensor detects the temperature increase, it should activate the next step (cell lysis), by promoting transcription of protein E.
References
- Contois, D. E. "Kinetics of bacterial growth: relationship between population density and specific growth rate of continuous cultures." Microbiology 21.1 (1959): 40-50. doi: 10.1099/00221287-21-1-40
