Team:ETH Zurich/Model/In Vivo
Behavior of CATE inside Tumor
We developed a model to gauge the behavior of our sensing circuit in the real life conditions of solid tumor colonization. Since it was not practically feasible to conduct experiments of bacterial colonization inside tumors, we used literature data from reference to simulate different bacterial colonization patterns.
The following were simulated using COMSOL:
- Different bacterial colonization patterns
- Homogeneous distribution in a Single spherical shell layer in tumour
- Heterogeneous distribution in a Single spherical shell layer in tumour
- Heterogeneous distribution in Double spherical shell layer in tumour
- Homogeneous distribution throughout Healthy tissue
As explained in linkToModelPage bacteria are shown to colonize in a spherical shell layer. We also tried a few other colonization patterns to show our system works as expected in a tumour while stays dormant in healthy tissue.
- Homogeneous distribution in a Single spherical shell layer in tumour
- Diffusion physics added to extend the ODEs used earlier into PDEs
How
Results
Beautiful GIFs coming soon .... MUST REALLY SOON
