Team:Oxford/Software

Software Tool

Disease	Parasite	Specific Protease	DNA Sequence of Cleavage Site	Protease Cleavage Sequence	Medium of Test	Final Output	Positive Result
Congenital Chagas Disease	Trypanosoma Cruzi	Cruzipain	AAAAAAGTTAAAGCTAAAAAA	K/K/L/KR-A/KS/K/RQ	Blood	Hirudin	No blood clotting
Sepsis	Pseudomonas aeruginosa	LasA		After Gly-Gly (e.g. PGVGG - elastin) or between Lys-Ile (e.g. NKKIEKFQ(S-P) - beta=casein)	Blood	Hirudin	No blood clotting
African Sleeping sickness	Trypanosoma brucei	Rhodesain/Brucepain	TCCGCGCCGAAATCCCTGATTGGC/ TCCGCGCCGCGTTCCCTGATTGGC	S/A/P/R-K/S/L/I/G	Blood	Hirudin	No blood clotting
Schistosomiasis	Schistosoma mansoni	Cercarial elastase	AGCTGGCCGCTG	SWPL	Blood	Hirudin	No blood clotting
Congenital toxoplasmosis	Toxoplasma gondii	Cathepsin L		KQKLR	Amniotic fluid