Team:INSA-UPS France

Croc'n Cholera

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What is cholera ?

The culprit :
Vibrio cholerae

Contaminates water and affects people in developing countries, war zones and natural disaster zones

2011

Last epidemy in an occidental country

4 millions

Number of cases per year

42

Number of concerned countries

→ Implemented solutions and their problems :

Too complicated to measure out

Too complicated to set up for big volumes

Too expensive

Our solution :
A synthetic biology innovative approach !

Fight V. cholerae with crocodile antimicrobial peptides !

What is our project ?

Our savior :
Sobki the crocodile

Can produce antimicrobial peptides that enables him to destroy V. cholerae in his natural habitat

Our system is made of two engineered microorganisms: Vibrio harveyi to detect V. cholerae and Pichia pastoris to produce crocodile AMPs. Thus one of our biggest challenge is to create an eukaryote-prokaryote communication system.