We want to design a biosensor capable of detecting and reacting to any DNA sequence by using the dCas9 and T7 polymerase coupled system. Currently we have devised two possible schemes for its appliance: cancer detection and prevention as well as biotic control. Our first envision on the biosensor is using it to detect the fusion gene EML4-ALK and produce signals, allowing efficient diagnoses of lung cancer.
The second envision is enabling our biosensor to spot potentially dangerous experimental cells and initiate cell self-killing process when the cells escape its original habitat. This could build a much safer experimental environment. Our detection system is promising because through designing different target sequences for the biosensor it can be applied to detection of many other types of cancers or genetic diseases.

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Team:BGIC-Union

Team:BGIC-UNION

BGIC-UNION

dCasKnight

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