Team:INSA-UPS France

Croc'n Cholera

Home

What

 

is

 

cholera?

The culprit:
Vibrio cholerae

Contaminates water and affects people in developing countries, war zones and natural disaster zones

2011

Last epidemy in an occidental country

4 millions

Number of cases per year

42

Number of concerned countries

→ Implemented solutions and their problems:

Too complicated to measure out

Too complicated to set up for big volumes

Too expensive

Our solution :
A synthetic biology innovative approach!

Fight V. cholerae with crocodile antimicrobial peptides!

What

 

is

 

our

 

project?

Our savior:
Sobki the crocodile

Can produce antimicrobial peptides that enables him to destroy V. cholerae in his natural habitat

Our system is made of two engineered microorganisms: Vibrio harveyi to detect V. cholerae and Pichia pastoris to produce crocodile AMPs. Thus one of our biggest challenge is to create an eukaryote-prokaryote communication system.