Difference between revisions of "Team:UCSC/Acetaminophen"
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<li>[1] World Health Organization, ed.,<span class="reference-italic">The Selection and Use of Essential Medicines: report of theWHO Expert Committee, 2007 ; (including the 15th model list of essential medicines).</span> No. 946in WHO Technical Report Series, Geneva: World Health Organization, 2007. OCLC: 254437808.</li> | <li>[1] World Health Organization, ed.,<span class="reference-italic">The Selection and Use of Essential Medicines: report of theWHO Expert Committee, 2007 ; (including the 15th model list of essential medicines).</span> No. 946in WHO Technical Report Series, Geneva: World Health Organization, 2007. OCLC: 254437808.</li> | ||
| + | <li>[23] P. N. Newton, M. D. Green, and F. M. Fern ́andez, “Impact of poor-quality medicines in the‘developing’ world,”<span class="reference-italic">Trends in Pharmacological Sciences</span>, vol. 31, pp. 99–101, Mar. 2010.</li> | ||
| + | <li>[24] S. A. Schug, D. A. Sidebotham, M. McGuinnety, J. Thomas, and L. Fox, “Acetaminophen as anadjunct to morphine by patient-controlled analgesia in the management of acute postoperativepain,”<span class="reference-italic">Anesthesia and Analgesia</span>, vol. 87, pp. 368–372, Aug. 1998.</li> | ||
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Revision as of 22:19, 14 September 2017
Acetaminophen Metabolics
"Antipyretic drugs, by being analgesics, reduce not only the fever but also the pain."
~Clinical Manual of Fever in Children
We aim to genetically modify PCC 7942 to produce acetaminophen, a common mild anes-thetic and antipyretic recognized by the WHO as an essential medicine [1]. However, in many countrieswith lower regulations and faulty policies regarding drug manufacturing, acetaminophen can be syn-thesized with lethal toxins that result in hundreds of deaths worldwide [23]. Acetaminophen is oftenused in conjunction with opioid pain medications postoperatively to enhance pain relief, thus reducingreliance upon opioid pharmaceuticals [24].
