Difference between revisions of "Team:UCSC/Applied Design"

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<h3>★  ALERT! </h3>
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<p>This page is used by the judges to evaluate your team for the <a href="https://2017.igem.org/Judging/Medals">medal criterion</a> or <a href="https://2017.igem.org/Judging/Awards"> award listed above</a>. </p>
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<p> Delete this box in order to be evaluated for this medal criterion and/or award. See more information at <a href="https://2017.igem.org/Judging/Pages_for_Awards"> Instructions for Pages for awards</a>.</p>
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<h3>Best Applied Design Special Prize</h3>
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<h1>IMPLEMENTATION</h1><br>
  
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<p>This is a prize for the team that has developed a synbio product to solve a real world problem in the most elegant way. The students will have considered how well the product addresses the problem versus other potential solutions, how the product integrates or disrupts other products and processes, and how its lifecycle can more broadly impact our lives and environments in positive and negative ways.
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<p> After successfully inserting the synthesis pathways for acetaminophen and vitamin B12 into <i>Synechococcus elongatus 7942</i>, we plan on transferring our model to the GRAS (Generally Recognized As Safe) status cyanobacteria, <i>Arthrospira platensis</i>. Our pathway modifications should be readily transferable, allowing our engineered products to be made in a nutrient dense, widely consumed bacteria.</p><br>
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<p>The implementation of this idea requires completing of a thorough genetic system for <i>Arthrospira platensis</i>. Our team has gone so far as to prepare an axenic culture of <i>Arthrospira platensis UTEX 2340</i> for whole genome sequencing. Among other faculties, this will allow in depth analysis of <i>Arthrospira platensis</i> foreign DNA defense systems and improve transformation protocols with this GRAS status cyanobacterium. </p><br>
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To compete for the <a href="https://2017.igem.org/Judging/Awards">Best Applied Design prize</a>, please describe your work on this page and also fill out the description on the <a href="https://2017.igem.org/Judging/Judging_Form">judging form</a>.
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You must also delete the message box on the top of this page to be eligible for this prize.
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<p>Further improvements will be made to optimize product synthesis with the sampling of mutant strains of <i>Arthrospira platensis</i>, different promoters, optimized enzymes and growth conditions.</p><br>
  
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<h5>Inspiration</h5>
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<img class="cultures" src="https://static.igem.org/mediawiki/2017/6/69/CCALA_culture_collection.png" style="width:170px;height=130px">
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<p>Take a look at what some teams accomplished for this prize.</p>
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<p>Further next steps entail development of low-cost semi-continuous bioreactors and fulfillment of GRAS status application requirements.Post perfection of our product, Bugs without Borders looks to international distribution. To do so, a partnership with Doctors without Borders and reconnection with our international contacts would initiate effective permeation into isolated rural communities on a global scale. High efficiency solar-powered lights and batteries could be used to power photosynthesis in dark times while producing oxygen and engineered products grown in vitamins rich bacteria.</p></br>
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<li><a href="https://2016.igem.org/Team:NCTU_Formosa/Design">2016 NCTU Formosa</a></li>
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<li><a href="https://2016.igem.org/Team:HSiTAIWAN/Product?locationId=Design">2016 HSiTAIWAN</a></li>
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<li><a href="https://2016.igem.org/Team:Pasteur_Paris/Design">2016 Pasteur Paris</a></li>
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<h3>Interstellar Implementation <img class="bioreactor" src="https://static.igem.org/mediawiki/2017/1/1e/Bioreactor.png" style="width:380px;height=250px"></h3>
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<p>Other possibilities for product implementation lie in the future of interplanetary travel. Space exploration and settlement missions will look to minimalize their dependence from Earth and become self-sustaining. Libraries of engineered cyanobacteria could be freeze dried for immediate biosynthesis of pharmaceuticals[1], fuels[2], and foods[3]. Other medicine production pathways such as opioid synthesis would be explored in this scenario for a fully sustainable pharmacy. 
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Revision as of 17:47, 27 October 2017

IMPLEMENTATION


After successfully inserting the synthesis pathways for acetaminophen and vitamin B12 into Synechococcus elongatus 7942, we plan on transferring our model to the GRAS (Generally Recognized As Safe) status cyanobacteria, Arthrospira platensis. Our pathway modifications should be readily transferable, allowing our engineered products to be made in a nutrient dense, widely consumed bacteria.


The implementation of this idea requires completing of a thorough genetic system for Arthrospira platensis. Our team has gone so far as to prepare an axenic culture of Arthrospira platensis UTEX 2340 for whole genome sequencing. Among other faculties, this will allow in depth analysis of Arthrospira platensis foreign DNA defense systems and improve transformation protocols with this GRAS status cyanobacterium.


Further improvements will be made to optimize product synthesis with the sampling of mutant strains of Arthrospira platensis, different promoters, optimized enzymes and growth conditions.


Further next steps entail development of low-cost semi-continuous bioreactors and fulfillment of GRAS status application requirements.Post perfection of our product, Bugs without Borders looks to international distribution. To do so, a partnership with Doctors without Borders and reconnection with our international contacts would initiate effective permeation into isolated rural communities on a global scale. High efficiency solar-powered lights and batteries could be used to power photosynthesis in dark times while producing oxygen and engineered products grown in vitamins rich bacteria.


Interstellar Implementation

Other possibilities for product implementation lie in the future of interplanetary travel. Space exploration and settlement missions will look to minimalize their dependence from Earth and become self-sustaining. Libraries of engineered cyanobacteria could be freeze dried for immediate biosynthesis of pharmaceuticals[1], fuels[2], and foods[3]. Other medicine production pathways such as opioid synthesis would be explored in this scenario for a fully sustainable pharmacy.

S P O N S O R S
S O C I A L
C O N T A C T
Jack Baskin School of Engineering
University of California, Santa Cruz
1156 High Street
Santa Cruz, California, 95064