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| − | <div class="scale" id="overview" style="text-align:center">
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| − | <img src="https://static.igem.org/mediawiki/2017/a/a9/T--TokyoTech--circuit_map.jpg" style="width:30%; border: 1px dotted #333333;width: 30%; border-radius: 10px">
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| − | </div>
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| | | | |
| | <!-- Overview --> | | <!-- Overview --> |
| | <div class="w3-container" id="overview" style="margin-top:20px"> | | <div class="w3-container" id="overview" style="margin-top:20px"> |
| − | <h1 class="w3-xxxlarge w3-text-red" style="padding-bottom: 10px;padding-top: 10px"><b>Overview</b></h1> | + | <p style="text-indent: 1em">Do you want to photosynthesize or fix nitrogen by yourself? If one-time cancer treatment lasts forever, don't you think it's amazing? If you could coexist with bacteria, you could be a super human. We named this new type of human 'Coli Sapiens.' Currently, however, there's no way to co-culture bacteria and human cells under <span style="font-style: italic;">in vitro</span> conditions. If you'd like to co-culture them <b>artificially</b>, you have to clear two tasks below.</p> |
| − | <hr style="width:50px;border:5px solid red" class="w3-round">
| + | <h5 style="text-indent: 1em;padding-left: 3em"> |
| − | <p style="font-family: Poppins;font-size: 16px">Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.
| + | - Establishing a cross-kingdom talk between human cells and bacteria</h5> |
| − | </p>
| + | <h5 style="text-indent: 1em;padding-left: 3em"> |
| | + | - Sustaining the balance between human cells and bacteria</h5> |
| | + | <p style="text-indent: 1em"> |
| | + | To clear these tasks, we tried to establish a cross-kingdom talk and creating a co-culture model.</p> |
| | + | |
| | </div> | | </div> |
| | | | |
| | <img src="https://static.igem.org/mediawiki/2017/d/da/T--TokyoTech--ribbon_hr.png" alt="John" style="width:95%"> | | <img src="https://static.igem.org/mediawiki/2017/d/da/T--TokyoTech--ribbon_hr.png" alt="John" style="width:95%"> |
| | | | |
| − | | + | <div class=" scale" id=" overview" style="margin-top: 10px"> |
| − | <!-- Project -->
| + | <img src="https://static.igem.org/mediawiki/2017/4/40/Top_image12.png" alt="John" style="width:80%"> |
| − | <div class=" w3-container" id=" project" style="margin-top: 20px"> | + | |
| − | <h1 class="w3-xxxlarge w3-text-red" style="padding-bottom: 10px;padding-top: 10px"><b>Project </b><a href="https://2017.igem.org/Team:TokyoTech/Project"><button class="w3-button w3-red w3-padding-large w3-hover-black" style="font-size: 25px">Read More</button></a></h1> | + | |
| − | <hr style="width:50px;border:5px solid red" class="w3-round">
| + | |
| − | <p style="font-family: Poppins;font-size: 16px">Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.
| + | |
| − | </p>
| + | |
| | </div> | | </div> |
| | | | |
| − | <hr>
| + | <div class="w3-container" id="contact" style="margin-top:75px;text-align: center;"> |
| | + | <img src="https://static.igem.org/mediawiki/2017/d/da/T--TokyoTech--ribbon_hr.png" alt="John" style="width:95%"> |
| | + | </div> |
| | | | |
| − | <!-- Modeling -->
| + | <div class="w3-container" id=" contact" style="margin-top: 75px"> |
| − | <div class="w3-container" id=" modeling" style="margin-top: 20px"> | + | <p style="font-size: 16px">In a real world, multiple kinds of organisms co-exist and the ecosystem is sustained by their mutual dependence. However, in iGEM community, it's been a standard to use single organism in project and it's not an overstatement that most teams don't take it into account. Therefore, to target "true human organism", it's necessary to establish the system that human cells and bacteria co-exist under in vitro conditions. Our co-culture system will be a big progress for iGEM and synthetic biology. |
| − | <h1 class="w3-xxxlarge w3-text-red" style="padding-bottom: 10px;padding-top: 10px"><b>Modeling </b><a href="https://2017.igem.org/Team:TokyoTech/Modeling"><button class="w3-button w3-red w3-padding-large w3-hover-black" style="font-size: 25px">Read More</button></a></h1>
| + | |
| − | <hr style="width:50px;border:5px solid red" class="w3-round">
| + | |
| − | <p style="font-family: Poppins;font-size: 16px">Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public. | + | |
| | </p> | | </p> |
| | </div> | | </div> |
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| | | | |
| − | <!-- Human Practice -->
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| − | <div class="w3-container" id="hp" style="margin-top:20px">
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| − | <h1 class="w3-xxxlarge w3-text-red" style="padding-bottom: 10px;padding-top: 10px"><b>Human Practices </b><a href="https://2017.igem.org/Team:TokyoTech/Human_Practices"><button class="w3-button w3-red w3-padding-large w3-hover-black" style="font-size: 25px">Read More</button></h1>
| |
| − | <hr style="width:50px;border:5px solid red" class="w3-round">
| |
| − | <p style="font-family: Poppins;font-size: 16px">Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.
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| − | </p>
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| − | </div>
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| − |
| |
| − | <hr>
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| − |
| |
| − | <!-- Notebook -->
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| − | <div class="w3-container" id="notebook" style="margin-top:20px">
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| − | <h1 class="w3-xxxlarge w3-text-red" style="padding-bottom: 10px;padding-top: 10px"><b>Notebook </b><a href="https://2017.igem.org/Team:TokyoTech/Notebook"><button class="w3-button w3-red w3-padding-large w3-hover-black" style="font-size: 25px">Read More</button></a></h1>
| |
| − | <hr style="width:50px;border:5px solid red" class="w3-round">
| |
| − | <p style="font-family: Poppins;font-size: 16px">Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.
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| − | </p>
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| − | </div>
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| − |
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| − | <hr>
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| − |
| |
| − | <!-- Team -->
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| − | <div class="w3-container" id="team" style="margin-top:20px">
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| − | <h1 class="w3-xxxlarge w3-text-red" style="padding-bottom: 10px;padding-top: 10px"><b>Team </b><a href="https://2017.igem.org/Team:TokyoTech/Team"><button class="w3-button w3-red w3-padding-large w3-hover-black" style="font-size: 25px">Read More</button></a></h1>
| |
| − | <hr style="width:50px;border:5px solid red" class="w3-round">
| |
| − | <p style="font-family: Poppins;font-size: 16px">Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.
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| − | </p>
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| − | </div>
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| − |
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| − | <hr>
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| − |
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| − | <!-- PAGE CONTENT! -->
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| − |
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| − | <div class="w3-container" id="contact" style="margin-top:75px">
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| − | <img src="https://static.igem.org/mediawiki/2017/4/40/Top_image12.png" alt="John" style="width:100%">
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| − | </div>
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| − |
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| − |
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| − | <!-- Sponsers -->
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| − | <div class="w3-container" id="sponsers" style="margin-top:75px;">
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| − | <h1 class="w3-xxxlarge w3-text-red" style="padding-top: 10px;padding-bottom: 10px"><b>Sponsers</b></h1>
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| − | <hr style="width:50px;border:5px solid red" class="w3-round">
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| − | </div>
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| − | <div class="w3-row-padding">
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| − | <div class="w3-col m4 w3-margin-bottom">
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| − | <div class="w3-light-grey">
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| − | <img src="https://static.igem.org/mediawiki/2016/4/47/Tokyo_Tech_JASSO.gif" style="width:100%">
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| − | <div class="w3-container">
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| − | <h3>JASSO</h3>
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| − | </div>
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| − | </div>
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| − | </div>
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| − | <div class="w3-col m4 w3-margin-bottom">
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| − | <div class="w3-light-grey">
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| − | <img src="http://kuramae-old.tokyo.r-cms.jp/files/user/common/p_images/head_logo.gif" style="width:100%">
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| − | <div class="w3-container">
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| − | <h3>Kuramae Kougyoukai</h3>
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| − | </div>
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| − | </div>
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| − | </div>
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| − | <div class="w3-col m4 w3-margin-bottom">
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| − | <div class="w3-light-grey">
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| − | <img src="http://www.vmcs.ucdavis.edu/idt/images/idt-logo.jpg" style="width:100%">
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| − | <div class="w3-container">
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| − | <h3>IDT</h3>
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| − | </div>
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| − | </div>
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| − | </div>
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| − | </div>
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| | <!-- End page content --> | | <!-- End page content --> |
Do you want to photosynthesize or fix nitrogen by yourself? If one-time cancer treatment lasts forever, don't you think it's amazing? If you could coexist with bacteria, you could be a super human. We named this new type of human 'Coli Sapiens.' Currently, however, there's no way to co-culture bacteria and human cells under in vitro conditions. If you'd like to co-culture them artificially, you have to clear two tasks below.
- Establishing a cross-kingdom talk between human cells and bacteria
- Sustaining the balance between human cells and bacteria
To clear these tasks, we tried to establish a cross-kingdom talk and creating a co-culture model.
