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individuals' daily life. The circadian rhythm in human is predominantly under the | individuals' daily life. The circadian rhythm in human is predominantly under the | ||
regulation of melatonin, a hormone produced by pineal gland periodically in | regulation of melatonin, a hormone produced by pineal gland periodically in | ||
− | accordance with day-and-night photoperiod. This year we | + | accordance with day-and-night photoperiod. This year we wanted to use engineered |
− | <i>E.coli</i> to mimic this process in human as a promising dosing machine. We | + | <i>E.coli</i> to mimic this process in human as a promising dosing machine. We proposed to |
<strong>construct the melatonin biosynthesis pathway in <i>E.coli</i> to produce melatonin</strong>, and | <strong>construct the melatonin biosynthesis pathway in <i>E.coli</i> to produce melatonin</strong>, and | ||
simultaneously <strong>couple this process with optimized repressilator</strong>, a synthetic genetic | simultaneously <strong>couple this process with optimized repressilator</strong>, a synthetic genetic |
Revision as of 21:58, 1 November 2017