Difference between revisions of "Team:UCL"

 
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{{UCL}}
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    <title>UCL LIT</title>
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<body>
 
<body>
  
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<div class="row topster">
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<!-- Navbar -->
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    <center>
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    <div class="glowy">
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        <h2 > LIT </h2>
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        <h4>Systems</h4>
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    </div>
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    </center>
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    </div>
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<div style="margin:0 !important; padding:0 !important" class="container-fluid">
  
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<div id="light" class="row text-center">
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    <div id="top" class="row">
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    <p class="lighttext"><strong>T</strong>rying to reliably engineer cell structures?</p>
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        <p class="lighttext"><strong>Y</strong>es, we know it’s difficult.</p>
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        <p class="lighttext"><strong>H</strong>ow about adding some precision to targeting and controlling cellular mechanisms?</p>
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        <p class="lighttext"><strong>O</strong>ur proposal is to design novel modular optogenetic control systems, with applications in a wide variety of areas, from tissue engineering to architecture. The project includes engineering of an immediate cell adhesion response using cell adhesion molecules and photoactivatable linkers for structure generation. Another application for our control system will be the production of a photoactivatable molecular tool for the precise activation of genes of interest. By targeting the genes for the transcription factors Oct3/4, Sox2, Klf4 and c-Myc we will also aim to create a novel mechanism for de-differentiation in mammalian cells. In the future, the precise spatiotemporal control of gene expression will enable reliable construction of any biological structure and sensor system.</p>
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        </div>
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<div id="footer">
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         <a href="https://2017.igem.org/Team:UCL"><img src="https://static.igem.org/mediawiki/2017/9/92/Logotop.png" class="logo-top"></a>
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         <div class="container-fluid">
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            <div class="row">
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                <h3 class="footertext text-center">Tune into our wavelength</h3>
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                <br>
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                <div class="col-md-4">
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        <ul class="navy">
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                    <center>
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            <li id="drop1" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Description">PROJECT</a>
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                        <a class="btn btn-outline-primary" href="https://www.instagram.com/ucl_igem17/" role="button"><i class="fa fa-instagram" style="font-size:50px"
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                <ul class="navy-hidden">
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                        ></i></a>
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                    <li><a href="https://2017.igem.org/Team:UCL/Description" class="dropped">Description</a></li>
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                        <br>
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                    <li><a href="https://2017.igem.org/Team:UCL/Results" class="dropped">Results</a></li>
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                        <h4 class="footertext">Candid lab photos</h4>
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                    <li><a href="https://2017.igem.org/Team:UCL/Parts" class="dropped">Basic Parts</a></li>
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                     </center>
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                    <li><a href="https://2017.igem.org/Team:UCL/Composite_Part" class="dropped">Composites</a></li>
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                </div>
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                    <li><a href="https://2017.igem.org/Team:UCL/Part_Improvement" class="dropped">Gold Part</a></li>
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                     <li><a href="https://2017.igem.org/Team:UCL/InterLab" class="dropped">Interlab</a></li>
  
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                </ul>
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            </li>
  
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            <li id="drop" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Human_Practices">HUMAN PRACTICES</a>
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                <ul class="navy-hidden">
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                    <li><a href="https://2017.igem.org/Team:UCL/Human_Practices" class="dropped">Overview</a></li>
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                    <li><a href="https://2017.igem.org/Team:UCL/Engagement" class="dropped">Public Engagement</a></li>
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                    <li><a href="https://2017.igem.org/Team:UCL/HP/Gold_Integrated" class="dropped">Integrated Practices</a></li>
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                    <li><a href="https://2017.igem.org/Team:UCL/HP/Silver" class="dropped">HP Silver</a></li>
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                </ul>
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            </li>
  
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        <li id="drop5" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Model">MODELLING</a>
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                <ul class="navy-hidden">
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                    <li><a href="https://2017.igem.org/Team:UCL/Model" class="dropped">Overview</a></li>
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                    <li><a href="https://2017.igem.org/Team:UCL/Model1" class="dropped">GOLIT</a></li>
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                    <li><a href="https://2017.igem.org/Team:UCL/Model2" class="dropped">Optoflux</a></li>
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                    <li><a href="https://2017.igem.org/Team:UCL/Model4" class="dropped">LEGIT</a></li>
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                    <li><a href="https://2017.igem.org/Team:UCL/Model3" class="dropped">MOM</a></li>
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                    <li><a href="https://2017.igem.org/Team:UCL/Methods" class="dropped">Methods</a></li>
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                    <li><a href="https://2017.igem.org/Team:UCL/Glossary" class="dropped">Glossary</a></li>
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                </ul>
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            </li>
  
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                <div class="col-md-4">
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            <li id="drop3" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Entrepreneurship">ENTREPRENEURSHIP</a>
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                    <center>
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                <ul class="navy-hidden">
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                        <a class="btn btn-outline-primary" href="https://twitter.com/UCLiGEM" role="button"><i class="fa fa-twitter-square" style="font-size:50px"></i></a>
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                    <li><a href="https://2017.igem.org/Team:UCL/Entrepreneurship" class="dropped">Overview</a></li>
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                        <br>
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                    <li><a href="https://2017.igem.org/Team:UCL/Applied_Design" class="dropped">Applied Design</a></li>
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                        <h4 class="footertext">Our self-tweeting bacteria</h4>
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                    <li><a href="https://2017.igem.org/Team:UCL/Enterpreneurship/Business" class="dropped">Business Model</a></li>
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                    </center>
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                 </ul>
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                 </div>
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            </li>
  
  
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                <div class="col-md-4">
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            <li id="drop2" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Medals">OUR MEDALS</a></li>
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                    <center>
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                        <a class="btn btn-outline-primary" href="#" role="button"><i class="fa fa-facebook-square" style="font-size:50px"
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            <li id="drop6" class="navy-link"><a href="#about">PEOPLE</a>
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                        ></i></a>
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                        <br>
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                    <li><a href="https://2017.igem.org/Team:UCL/Team" class="dropped">Team</a></li>
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                        <h4 class="footertext">See what events are on</h4>
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                    <li><a href="https://2017.igem.org/Team:UCL/Collaborations" class="dropped">Collaborations</a></li>
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                     </center>
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                    <li><a href="https://2017.igem.org/Team:UCL/Attributions" class="dropped">Attributions</a></li>
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                </div>
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                </ul></li>
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            </div>
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         </div>
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            <li id="drop4" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Notebook">LAB BOOK</a>
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                <ul class="navy-hidden">
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                     <li><a href="https://2017.igem.org/Team:UCL/Safety" class="dropped">Safety</a></li>
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        </ul></li>
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         </ul>
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     </div>
 
     </div>
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</div>
  
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<!-- content -->
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<div id="home" class="container-fluid">
  
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                <div class="row">
  
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                    <!-- The background-->
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                            <p style="font-size: 18px; font-weight: 200" class="intro-homepage">UCL iGEM 2017 presents</p>
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<p class="intro-homepage">LIT (Light Induced Technologies)</p>
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                            <p class="text-content-new">We developed applications for biological light switches. The mission was to standardise optogenetic tools for wider use in synthetic biology and to show how we can apply them in tissue engineering, building architectural structures and producing bacterial light bulbs.</p>
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<div id="mam">
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<p class="pop-text">We developed a novel tissue engineering approach based on the use of an optogenetic guidance system that will allow scaffold-free, precise control of cellular behaviour using light switches.<span style="color: red"> </span></p>
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<div id="bulb">
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<p class="pop-text">We developed and prototyped a bacterial light-bulb - one that uses light-repressible bioluminescence and co-culturing to create an efficient and sustainable solution for public illumination. </p>
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<div id="barc">
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<p class="pop-text">We developed transcriptional and post-translational light switches for the induction of cell adhesion. Guided by light, cells will be directed to form 3D structures by adhering to each other and simultaneously producing, secreting and binding a desired polymer that can be then crosslinked into a solid 3D shape.</p>
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Latest revision as of 23:51, 1 November 2017

UCL LIT

UCL iGEM 2017 presents

LIT (Light Induced Technologies)

We developed applications for biological light switches. The mission was to standardise optogenetic tools for wider use in synthetic biology and to show how we can apply them in tissue engineering, building architectural structures and producing bacterial light bulbs.

We developed a novel tissue engineering approach based on the use of an optogenetic guidance system that will allow scaffold-free, precise control of cellular behaviour using light switches.

We developed and prototyped a bacterial light-bulb - one that uses light-repressible bioluminescence and co-culturing to create an efficient and sustainable solution for public illumination.

We developed transcriptional and post-translational light switches for the induction of cell adhesion. Guided by light, cells will be directed to form 3D structures by adhering to each other and simultaneously producing, secreting and binding a desired polymer that can be then crosslinked into a solid 3D shape.