Difference between revisions of "Team:UCL"

 
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{{Team:UCL/Bootstrap}}
 
{{Team:UCL/CSS}}
 
{{Team:UCL/CSS}}
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{{Team:UCL/Jquery}}
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<html>
 
<html>
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<head>
  
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<script src="http://www.google.com/jsapi" type="text/javascript"></script>
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    <title>UCL LIT</title>
  
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<script type="text/javascript">google.load("jquery", "1.3.2");</script>
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    <script>
  
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<script type="text/javascript">
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        $(document).ready(function(){
  
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    $(document).ready(function(){
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          $("#Mammalian_Icon").hover(function(){
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        $(".lighttext:eq(0)").delay(650).fadeIn(2500);
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                $("#mam").fadeIn("2500");
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        $(".lighttext:eq(1)").delay(2000).fadeIn(2500);
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            }, function(){
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        $(".lighttext:eq(2)").delay(3500).fadeIn(2800);
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                $("#mam").css("display", "none");
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        $(".lighttext:eq(3)").delay(5800).fadeIn(3000);
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            });
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    });
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</script>
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            $("#Barchitecture_Icon").hover(function(){
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                $("#barc").fadeIn("2500");
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            }, function(){
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                $("#barc").css("display", "none");
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            });
  
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            $("#Lightbulb_Icon").hover(function(){
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                $("#bulb").fadeIn("2500");
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            }, function(){
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                $("#bulb").css("display", "none");
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            });
  
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<head>
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        });
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<link rel="stylesheet" href="https://fonts.googleapis.com/css?family=Josefin+Sans"></link>
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     </script>
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<link rel="stylesheet" href="https://fonts.googleapis.com/css?family=Orbitron"></link>
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     <script src="https://ajax.aspnetcdn.com/ajax/jQuery/jquery-3.2.1.min.js"></script>
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    <link rel="stylesheet" href="https://maxcdn.bootstrapcdn.com/bootstrap/3.3.7/css/bootstrap.min.css"
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          integrity="sha384-BVYiiSIFeK1dGmJRAkycuHAHRg32OmUcww7on3RYdg4Va+PmSTsz/K68vbdEjh4u" crossorigin="anonymous">
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    <link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css">
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</head>
 
</head>
  
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<body class="container-fluid">
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<!-- Included an in-line CSS, as it's easier to put on the iGEM website -->
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<style>
  
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<div id="topster" class="row">
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     .image-content-here {
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     <div class="glowy">
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         height:200px;
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         <h2 > LIT </h2>
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        width:200px;
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    </div>
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        border-radius: 50%;
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    <h6 id="lit">Light Induced Technologies</h6>
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        margin: 0 25% 5% 0;
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     </div>
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        box-shadow: 0 4px 8px 0 rgba(0, 0, 0, 0.2);
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     }
  
 +
    .intro-homepage {
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        font-family: Lato !important;
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        font-size: 1.7em !important;
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        position:relative;
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        font-weight: 600;
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        padding: 0 1% 0 9%;
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        margin:0;
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        color: rgba(0, 0, 0, 0.69);
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    }
  
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<div id="light" class="row">
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    #switches {
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    <center>
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        border: none;
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    <p class="lighttext"><strong>T</strong>rying to reliably engineer cell structures?</p>
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        margin-top:0;
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        <p class="lighttext"><strong>Y</strong>es, we know it’s difficult.</p>
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    }
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        <p class="lighttext"><strong>H</strong>ow about adding some precision to targeting and controlling cellular mechanisms?</p>
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−
        <p class="lighttext"><strong>O</strong>ur proposal is to design modular optogenetic control systems that provide spatiotemporal control, with applications ranging from tissue engineering to architecture. The aim is to trigger and control immediate cell adhesion responses in both bacterial and mammalian cells. Controlling the SpyTag-SpyCatcher link formation through light will ensure precise bacterial cell adhesion. The formed structure will act as a scaffold for producing durable polymers from the cells, such as PHA. In mammalian cells, we are using light to control cadherin inhibitors and to generate cell structures resembling epithelia. The light control system will also selectively activate genes involved in the de-differentiation of mammalian cells (e.g. genes for the transcription factors Oct3/4, Sox2, Klf4) . In the future, the precise spatiotemporal control of gene expression will enable reliable construction of any biological structure.</p>
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    #box1 {
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     </center>
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        position:absolute;
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        height:400px;
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        width:500px;
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        margin:3% 0 0 3%;
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        z-index:3;
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    }
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    #box4 {
 +
        position:absolute;
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        height:200px;
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        width:500px;
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        margin:30% 0 0 60%;
 +
        z-index:3;
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    }
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    #mam,#bulb, #barc {
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        display:none;
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position: absolute;
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z-index:4;
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                box-shadow:0 4px 8px 0 rgba(0, 0, 0, 0.2);
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    }
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#mam {
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background-color: #2262fb;
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margin: 10% 5% 0 65%;
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}
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#bulb {
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background-color: #f8894b;
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margin: 10% 5% 0 65%;
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}
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#barc {
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        background-color: #5f26d6;
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margin: 10% 5% 0 65%;
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}
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 +
.pop-text {
 +
font-size: 1.4vw !important;
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color: white;
 +
font-family: Lato !important;
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padding: 3% 5% 2% 5%;
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}
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 +
 
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#Mammalian_Icon, #Lightbulb_Icon, #Barchitecture_Icon  {
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animation: float 3s ease-in-out infinite;
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}
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@keyframes float {
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0% {
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transform: translatey(0px);
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}
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50% {
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transform: translatey(-7px);
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}
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100% {
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transform: translatey(0px);
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}
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}
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</style>
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<body>
 +
 
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<!-- Navbar -->
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 +
<div style="margin:0 !important; padding:0 !important" class="container-fluid">
 +
 
 +
    <div id="top" class="row">
 +
 
 +
        <a href="https://2017.igem.org/Team:UCL"><img src="https://static.igem.org/mediawiki/2017/9/92/Logotop.png" class="logo-top"></a>
 +
 
 +
        <ul class="navy">
 +
            <li id="drop1" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Description">PROJECT</a>
 +
                <ul class="navy-hidden">
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Description" class="dropped">Description</a></li>
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                    <li><a href="https://2017.igem.org/Team:UCL/Results" class="dropped">Results</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Parts" class="dropped">Basic Parts</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Composite_Part" class="dropped">Composites</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Part_Improvement" class="dropped">Gold Part</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/InterLab" class="dropped">Interlab</a></li>
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 +
                </ul>
 +
            </li>
 +
 
 +
            <li id="drop" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Human_Practices">HUMAN PRACTICES</a>
 +
                <ul class="navy-hidden">
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Human_Practices" class="dropped">Overview</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Engagement" class="dropped">Public Engagement</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/HP/Gold_Integrated" class="dropped">Integrated Practices</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/HP/Silver" class="dropped">HP Silver</a></li>
 +
                </ul>
 +
            </li>
 +
 
 +
        <li id="drop5" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Model">MODELLING</a>
 +
                <ul class="navy-hidden">
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Model" class="dropped">Overview</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Model1" class="dropped">GOLIT</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Model2" class="dropped">Optoflux</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Model4" class="dropped">LEGIT</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Model3" class="dropped">MOM</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Methods" class="dropped">Methods</a></li>
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                    <li><a href="https://2017.igem.org/Team:UCL/Glossary" class="dropped">Glossary</a></li>
 +
                </ul>
 +
            </li>
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 +
            <li id="drop3" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Entrepreneurship">ENTREPRENEURSHIP</a>
 +
                <ul class="navy-hidden">
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Entrepreneurship" class="dropped">Overview</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Applied_Design" class="dropped">Applied Design</a></li>
 +
                    <li><a href="https://2017.igem.org/Team:UCL/Enterpreneurship/Business" class="dropped">Business Model</a></li>
 +
                </ul>
 +
            </li>
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            <li id="drop2" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Medals">OUR MEDALS</a></li>
 +
 
 +
            <li id="drop6" class="navy-link"><a href="#about">PEOPLE</a>
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                <ul class="navy-hidden">
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                    <li><a href="https://2017.igem.org/Team:UCL/Team" class="dropped">Team</a></li>
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                    <li><a href="https://2017.igem.org/Team:UCL/Collaborations" class="dropped">Collaborations</a></li>
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                    <li><a href="https://2017.igem.org/Team:UCL/Attributions" class="dropped">Attributions</a></li>
 +
                </ul></li>
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            <li id="drop4" class="navy-link"><a href="https://2017.igem.org/Team:UCL/Notebook">LAB BOOK</a>
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                <ul class="navy-hidden">
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                    <li><a href="https://2017.igem.org/Team:UCL/Safety" class="dropped">Safety</a></li>
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        </ul></li>
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        </ul>
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 +
     </div>
 
</div>
 
</div>
  
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    <div id="footer" class="container-fluid">
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<!-- content -->
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            <div class="row">
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<div id="home" class="container-fluid">
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                <h3 class="footertext text-center">Tune into our wavelength</h3>
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                <br>
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                 <div class="col-md-4">
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                 <div class="row">
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                     <center>
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                        <a class="btn btn-outline-primary" href="https://www.instagram.com/ucl_igem17/" role="button"><i class="fa fa-instagram" style="font-size:50px; color: inherit"
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                     <!-- The background-->
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                        ></i></a>
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                    <div style="position:absolute; z-index:1" class="col-sm-12">
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                        <br>
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                        <h4 class="footertext">Candid lab photos</h4>
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<svg version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px"
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                            <p style="font-size: 18px; font-weight: 200" class="intro-homepage">UCL iGEM 2017 presents</p>
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<p class="intro-homepage">LIT (Light Induced Technologies)</p>
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                            <p class="text-content-new">We developed applications for biological light switches. The mission was to standardise optogenetic tools for wider use in synthetic biology and to show how we can apply them in tissue engineering, building architectural structures and producing bacterial light bulbs.</p>
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<p class="pop-text">We developed a novel tissue engineering approach based on the use of an optogenetic guidance system that will allow scaffold-free, precise control of cellular behaviour using light switches.<span style="color: red"> </span></p>
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<p class="pop-text">We developed and prototyped a bacterial light-bulb - one that uses light-repressible bioluminescence and co-culturing to create an efficient and sustainable solution for public illumination. </p>
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<p class="pop-text">We developed transcriptional and post-translational light switches for the induction of cell adhesion. Guided by light, cells will be directed to form 3D structures by adhering to each other and simultaneously producing, secreting and binding a desired polymer that can be then crosslinked into a solid 3D shape.</p>
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                        <h4 class="footertext">Our self-tweeting bacteria</h4>
 
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                        ></i></a>
 
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                        <h4 class="footertext">See what events are on</h4>
 
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Latest revision as of 23:51, 1 November 2017

UCL LIT

UCL iGEM 2017 presents

LIT (Light Induced Technologies)

We developed applications for biological light switches. The mission was to standardise optogenetic tools for wider use in synthetic biology and to show how we can apply them in tissue engineering, building architectural structures and producing bacterial light bulbs.

We developed a novel tissue engineering approach based on the use of an optogenetic guidance system that will allow scaffold-free, precise control of cellular behaviour using light switches.

We developed and prototyped a bacterial light-bulb - one that uses light-repressible bioluminescence and co-culturing to create an efficient and sustainable solution for public illumination.

We developed transcriptional and post-translational light switches for the induction of cell adhesion. Guided by light, cells will be directed to form 3D structures by adhering to each other and simultaneously producing, secreting and binding a desired polymer that can be then crosslinked into a solid 3D shape.