Difference between revisions of "Team:Arizona State"

 
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{{Arizona State}}
 
{{Arizona State}}
 
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<img src="https://scontent.fphx1-2.fna.fbcdn.net/v/t34.0-12/20068278_1956282334613858_1935463783_n.png?oh=d031dd503b11677ccaa99bc69bc69911&oe=597213F1"height=220px><br>
 
 
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                    <img src="https://static.igem.org/mediawiki/2017/1/1e/IGEM_ASU.png" height=220px><br>
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                  <br>
                     <h1> <b>ASU 2017 iGEM TEAM: QUORUM SENSING</h1>
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<img src="https://static.igem.org/mediawiki/2017/e/ee/ASu_ever_qst.png"style="width:1228px;height:928px;/>
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                     <h1> Abstract Header</h1>
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                    <p Insert text here. </p>
 
                     <h2>Diverse homoserine lactone systems for cellular communication</h2>
 
                     <h2>Diverse homoserine lactone systems for cellular communication</h2>
  
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         <center><img src="https://static.igem.org/mediawiki/2016/f/f3/T--Arizona_State--ASUfrontpage1.png"></center>
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         <h1 class = "center"> Our Project </h1>
 
         <h1 class = "center"> Our Project </h1>
         <p class = "big home-text">Quorum sensing (QS) allows bacteria to sense the surrounding
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         <p> Homoserine lactones (HSLs) are a family of small molecules used to coordinate behavior in some bacteria. Group regulation is known as quorum sensing (QS) and is responsible for behaviors such as bacterial virulence, growth, and bioluminescence. Genetic components from QS systems have been modularized by synthetic biologists and incorporated into synthetic circuits. A significant hurdle to using HSLs in synthetic systems is cross-reactivity between a sender and non-target receivers. Crosstalk can be mitigated by orthogonal systems that do not communicate with each other. Our project characterizes interactions between HSL-producing sender cells and our newly developed receivers (LasR, TraR, and RpaR) using an HSL-induced GFP reporter system. We expect to add 3 new well-characterized receivers to build upon foundational advances such as the work with LuxR (BBa_F2620) by Dr. Barry Canton. Our work also builds upon important research in biosafety (from our 2016 project) by using ethyl alcohol eliminate HSL bioactivity. </p>
            cell population density and communicate with their neighbors. They do this by producing
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            N-acyl homoserine lactones (AHLs), which can diffuse back into the bacteria at high concentrations.
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            In the cell they bind to receiver proteins, which then activate gene expression in a coordinated manner. There are many natural QS systems, but only four in popular use by synthetic biologists. Some of these systems use AHLs that can activate multiple receiver systems or "crosstalk" between networks. This can cause problems when using QS in higher-level designs. Our project aims to characterize a variety of AHL networks, which will increase the number of functional QS systems with minimal crosstalk in
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            synthetic biology. </p>
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             <div class = "col-sm-6">
 
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             <h2>The ASU Team</h2>
 
             <h2>The ASU Team</h2>
                 <img src="https://static.igem.org/mediawiki/2016/7/78/T--Arizona_State--igemteampic.jpg" class = "team-pic"/>
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                 <h2>Check out our Twitter!</h2>
 
                 <h2>Check out our Twitter!</h2>
                <!--<img src="https://static.igem.org/mediawiki/2016/6/6c/T--Arizona_State--hayneslabworkphoto.jpg" height=300px/>-->
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                 <a class="twitter-timeline" data-width="400" data-height="400" href="https://twitter.com/asuigem">Tweets by asuigem</a>
 
                 <a class="twitter-timeline" data-width="400" data-height="400" href="https://twitter.com/asuigem">Tweets by asuigem</a>
 
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                     Visit our website >
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                     Visit our Wordpress >
 
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     <div class="section1 container-fluid">
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    <div class = "row footer" style = "margin-bottom: -50px">
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          <a href = "/Team:Arizona_State/Description"><div class = "col-sm-4 footer-button design">
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              <p>Description</p>
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          </div></a>
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          <a href = "/Team:Arizona_State/Results"><div class = "col-sm-4 footer-button results">
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              <p>Results</p>
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          </div></a>
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          <a href = "/Team:Arizona_State/Notebook"><div class = "col-sm-4 footer-button notebook">
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              <p>Notebook</p>
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          </div></a>
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          <a href = "/Team:Arizona_State/Safety"><div class = "col-sm-4 footer-button safety">
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              <p>Safety</p>
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          </div></a>
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          <a href = "/Team:Arizona_State/Parts"><div class = "col-sm-4 footer-button parts">
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              <p>Parts and Design</p>
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          </div></a>
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          <a href = "/Team:Arizona_State/Human_Practices"><div class = "col-sm-4 footer-button hp">
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              <p>Human Practices</p>
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          </div></a>
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Latest revision as of 01:28, 2 November 2017