Difference between revisions of "Team:TokyoTech"

 
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<p class="drescription">We plan to establish an artificial co-culture system of human cells with bacteria (E. coli) by integration of quorum sensing (cell-to-cell communication between bacteria), His-Asp phosphorelay and cytokinin (a signaling molecule in plant) in this co-existing system</p>
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<p class="popup-parapraph">we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy.</p>
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<p class="popup-parapraph">Showing protocol and the other detail about the project.</p>
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<p class="popup-parapraph">#tokyotechpride</p>
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<p class="right-color">&copy; Copyright 2017. All rights reserved by <a href="https://96haji.me/" target="_blank">Hajime Fujita</a></p>
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 +
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    <h4 style="text-indent: 1em;color: #4a0f0c">Do you want to photosynthesize or fix nitrogen by yourself?</h4>
 +
    <h4 style="text-indent: 1em;color: #4a0f0c">
 +
    If one-time cancer treatment lasts forever, don't you think it's amazing?</h4>
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    <p style="text-indent: 1em;font-size: 18px;padding-top: 15px">
 +
    If you could co-exist with bacteria, you could be a super human. We named this new type of human 'Coli Sapiens.' Currently, however, there's no way to co-culture bacteria and human cells under <span style="font-style: italic;">in vitro</span> conditions. If you'd like to co-culture them <b>artificially</b>, you have to clear two tasks below.</p>
 +
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1. Establishing a cross-kingdom talk between human cells and bacteria</h4>
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2. Sustaining the balance between human cells and bacteria</h4>
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To clear these tasks, we tried to establish a cross-kingdom talk and creating a co-culture model.</p>
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    <img src="https://static.igem.org/mediawiki/2017/4/40/Top_image12.png" alt="John" style="width:80%">
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    <p style="font-size: 18px;text-indent: 1em">In a real world, multiple kinds of organisms co-exist and the ecosystem is sustained by their mutual dependence. However, in iGEM community, it's been a standard to use single organism in project and it's not an overstatement that most teams don't take it into account. Therefore, to target "true human organism", it's necessary to establish the system that human cells and bacteria co-exist under <span style="font-style: italic;">in vitro</span> conditions. Our co-culture system will be a big progress for iGEM and synthetic biology.
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Latest revision as of 02:56, 2 November 2017

<!DOCTYPE html> Coli Sapiens

iGEM Tokyo Tech

Do you want to photosynthesize or fix nitrogen by yourself?

If one-time cancer treatment lasts forever, don't you think it's amazing?

If you could co-exist with bacteria, you could be a super human. We named this new type of human 'Coli Sapiens.' Currently, however, there's no way to co-culture bacteria and human cells under in vitro conditions. If you'd like to co-culture them artificially, you have to clear two tasks below.

1. Establishing a cross-kingdom talk between human cells and bacteria

2. Sustaining the balance between human cells and bacteria

To clear these tasks, we tried to establish a cross-kingdom talk and creating a co-culture model.

John

In a real world, multiple kinds of organisms co-exist and the ecosystem is sustained by their mutual dependence. However, in iGEM community, it's been a standard to use single organism in project and it's not an overstatement that most teams don't take it into account. Therefore, to target "true human organism", it's necessary to establish the system that human cells and bacteria co-exist under in vitro conditions. Our co-culture system will be a big progress for iGEM and synthetic biology.

Hajime Fujita with W3.CSS: All Rights Reserved