Difference between revisions of "Team:TokyoTech"

 
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<body>
 
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    </li>
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    <li style="margin-bottom: 10px; border: 5px double #fff; border-radius: 10px">
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    <label for="vmcb-b"><a href="https://2017.igem.org/Team:TokyoTech/Medal">Achievements</a></label>
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    <li><a href="#overview" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">1</a></li>
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      <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/Description" class="w3-bar-item w3-button w3-hover-white">Description</a></li>
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      <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/Project/Basic_Parts" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">Basic Parts</a></li>
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      <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/Project/Composite_Parts" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">Composite Parts</a></li>
 
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          <label for="vmcb-d2"><a style="text-align: center;">Bacteria to <br>Human Cells ▼</a></label>
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            <ul>
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              <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/Experiment/TraI_Assay" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">TraI Assay</a></li>
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              <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/Experiment/TraI_Improvement" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">TraI Improvement <br>Assay</a></li>
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              <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/Experiment/TraR_Reporter_Assay" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white" >TraR Reporter <br>Assay</a></li>
 +
              <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/Experiment/Transcriptome_Analysis" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">Transcriptome <br>Analysis</a></li>
 +
              <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/Experiment/Chimeric_Transcription_Factor" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">Chimeric <br> Transcription <br> Factor Assay</a></li>
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     <label for="vmcb-d3"><a style="text-align: center;">Human Cells to <br>Bacteria ▼</a></label>
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    <label for="vmcb-f"><a>Human Practices</a></label>
 
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     <li><a href="#overview" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">1</a></li>
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     <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/HP" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">Overview</a></li>
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    <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/HP/Silver" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">Silver</a></li>
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    <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/HP/Gold_Integrated" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">Gold (Integrated)</a></li>
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    <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/Demonstrate" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">Demonstrate</a></li>
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    <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/Collaborations" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">Collaborations</a></li>
 
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     <li><a href="#overview" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">1</a></li>
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     <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/Team" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">Team</a></li>
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    <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/Attributions" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">Attributions</a></li>
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    <li style="text-align: center;"><a href="https://2017.igem.org/Team:TokyoTech/Sponsors" onclick="w3_close()" class="w3-bar-item w3-button w3-hover-white">Sponsors</a></li>
 
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<img src="https://static.igem.org/mediawiki/2017/1/14/T--TokyoTech--slideshow_no.2_2.jpg">
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<div class="w3-container" id="overview" style="padding-top:20%;padding-bottom: 15px;text-align: center;">
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    <h1 class="w3-xxxlarge w3-text-red" style="padding-bottom: 10px;padding-top: 10px"><b>Overview</b></h1>
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     <h4 style="text-indent: 1em;color: #4a0f0c">Do you want to photosynthesize or fix nitrogen by yourself?</h4>
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     <p style="font-family: Poppins;font-size: 16px">Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.
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    If one-time cancer treatment lasts forever, don't you think it's amazing?</h4>
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<img src="https://static.igem.org/mediawiki/2017/d/da/T--TokyoTech--ribbon_hr.png" alt="John" style="width:95%">
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<div class="w3-container" id="overview" style="padding-top:5px;padding-bottom: 5px;text-align: center;">
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<center><hr style="width:300px;border:3px solid red" class="w3-round"></center>
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<div class="w3-container" id="overview" style="padding-top:15px;padding-bottom: 15px;text-align: center;color: #4a0f0c">
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    <p style="text-indent: 1em;font-size: 18px;padding-top: 15px">
 +
    If you could co-exist with bacteria, you could be a super human. We named this new type of human 'Coli Sapiens.' Currently, however, there's no way to co-culture bacteria and human cells under <span style="font-style: italic;">in vitro</span> conditions. If you'd like to co-culture them <b>artificially</b>, you have to clear two tasks below.</p>
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    <h1 class="w3-xxxlarge w3-text-red" style="padding-bottom: 10px;padding-top: 10px"><b>Project  </b><a href="https://2017.igem.org/Team:TokyoTech/Project"><button class="w3-button w3-red w3-padding-large w3-hover-black" style="font-size: 25px">Read More</button></a></h1>
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<h4 style="text-indent: 1em;color: #4a0f0c">
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1. Establishing a cross-kingdom talk between human cells and bacteria</h4>
−
    <p style="font-family: Poppins;font-size: 16px">Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.
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<h4 style="text-indent: 1em;color: #4a0f0c">
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2. Sustaining the balance between human cells and bacteria</h4>
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<div class="w3-container" id="overview" style="padding-top:15px;padding-bottom: 15px;text-align: center;color: #4a0f0c;border: 5px">
  
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To clear these tasks, we tried to establish a cross-kingdom talk and creating a co-culture model.</p>
−
    <h1 class="w3-xxxlarge w3-text-red" style="padding-bottom: 10px;padding-top: 10px"><b>Modeling  </b><a href="https://2017.igem.org/Team:TokyoTech/Modeling"><button class="w3-button w3-red w3-padding-large w3-hover-black" style="font-size: 25px">Read More</button></a></h1>
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    <hr style="width:50px;border:5px solid red" class="w3-round">
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    <p style="font-family: Poppins;font-size: 16px">Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.
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    <p style="font-family: Poppins;font-size: 16px">Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.
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     <p style="font-size: 18px;text-indent: 1em">In a real world, multiple kinds of organisms co-exist and the ecosystem is sustained by their mutual dependence. However, in iGEM community, it's been a standard to use single organism in project and it's not an overstatement that most teams don't take it into account. Therefore, to target "true human organism", it's necessary to establish the system that human cells and bacteria co-exist under <span style="font-style: italic;">in vitro</span> conditions. Our co-culture system will be a big progress for iGEM and synthetic biology.
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    <p style="font-family: Poppins;font-size: 16px">Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.
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    <p style="font-family: Poppins;font-size: 16px">Gene therapy has been expected in cancer therapy for years. An interesting therapy for cancer using anaerobic bacteria as a carrier has been developed, but after the anaerobic cancer region is diminished, the bacteria cannot stay there anymore. If anti-cancer bacteria can stay in affected area, they promptly respond to cancer recurrence. Co-existence of bacteria and host cells should be quite difficult in our body or human cell culture systems, because bacteria grow so fast. It is important to control bacterial proliferation in them. So, we try to establish a new living system that human cells control the population of bacteria by engineering the both cells by creating two signaling pathways of 1) Bacteria-Mammals and 2) Bacteria-Plants. We expect that this system will lead to a new experimental approach and a new medical therapy. Moreover, we imagine about "A boundary between cellular groups and living organisms" with general public.
 
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<div class="w3-light-grey w3-container w3-padding-32" style="margin-top:75px;padding-right:58px"><p class="w3-right">Hajime Fujita:  <a href="96haji.me" title="W3.CSS" target="_blank" class="w3-hover-opacity">All Rights Reserved</a></p></div>
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<div class="w3-light-grey w3-container w3-padding-32" style="margin-top:75px;padding-right:58px"><p class="w3-right"><a href="http://96haji.me/" title="W3.CSS" target="_blank" class="w3-hover-opacity">Hajime Fujita with W3.CSS: All Rights Reserved</a></p></div>
  
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Latest revision as of 02:56, 2 November 2017

<!DOCTYPE html> Coli Sapiens

iGEM Tokyo Tech

Do you want to photosynthesize or fix nitrogen by yourself?

If one-time cancer treatment lasts forever, don't you think it's amazing?

If you could co-exist with bacteria, you could be a super human. We named this new type of human 'Coli Sapiens.' Currently, however, there's no way to co-culture bacteria and human cells under in vitro conditions. If you'd like to co-culture them artificially, you have to clear two tasks below.

1. Establishing a cross-kingdom talk between human cells and bacteria

2. Sustaining the balance between human cells and bacteria

To clear these tasks, we tried to establish a cross-kingdom talk and creating a co-culture model.

John

In a real world, multiple kinds of organisms co-exist and the ecosystem is sustained by their mutual dependence. However, in iGEM community, it's been a standard to use single organism in project and it's not an overstatement that most teams don't take it into account. Therefore, to target "true human organism", it's necessary to establish the system that human cells and bacteria co-exist under in vitro conditions. Our co-culture system will be a big progress for iGEM and synthetic biology.

Hajime Fujita with W3.CSS: All Rights Reserved