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Revision as of 07:17, 15 October 2017
Collaborations
Columbia
A couple members from the Columbia University's iGEM Team met with our team in order to discuss our projects and share ideas about putting our projects together. The Columbia iGEM Team mentored us by helping write our abstract, edit our writing, and look over our website. One of the Columbia team members is an alum of the TP-CC San Diego Team before going to Columbia University, so he was able to help move our team forward. Our meeting was very informative for all team members and also helped us get a glimpse into an Undergraduate iGEM Team. This was a part of our Human Practices effort to connect with teams from different places across the country.
Hello World
In 1965, extrachromosomal DNA (ecDNA) was discovered; DNA free from its traditional homes in the nucleus was documented. One study taking a look at ecDNA by means of fluorescence in situ hybridization proposed the ecDNA’s unusual number of oncogenes, but it didn’t catch enough attention because it was considered to be a rare event. Not until recently has the importance of ecDNA been revisited. The most recent study revealed that nearly 40% of oncogenes reside on ecDNA rather than the widely accepted notion that all DNA resided only on chromosomes.
Hello World
Similar to chromosomal DNA, ecDNA is composed by double strands of nucleic acid but form a circular structure. More importantly, ecDNA does not have a centromere for spindle fiber binding during mitosis. This unique feature allows rapid DNA multiplication and random segregation to create high heterogeneity in daughter cells during cell proliferation, implying a possible correlative relationship between the development of tumors and a faster resistance to existing treatments.
