Difference between revisions of "Team:ETH Zurich"

 
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<div class="banner">
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<figure class="banner" id="banner">
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    <img src="https://static.igem.org/mediawiki/2017/c/c3/T--ETH_Zurich--Banner.png" alt="CATE" />
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</figure>
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<figure class="scroll">
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<a class="scroll-down-button" href="#scrollstart">
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    <img src="https://static.igem.org/mediawiki/2017/1/14/T--ETH_Zurich--Scroll.png">
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<figure>
 
</div>
 
</div>
  
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<section id="scrollstart"></section>
  
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<section id="start" class="step">
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    <div class="why">
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    <h1>WHY</h1>
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        <p>Cancer kills over 8 million people every year. That's as much as the entire population of Switzerland!</p>
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        <p>We need more specific therapies because current approaches result in many side-effects. That's why we invented <span title="Came close to being FUSBa (<yyyeaah no ;))">CATE</span>, the first all-in-one living cancer therapeutic with an integrated two-step safety mechanism.
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        <p>A living cure to a living disease!</p>
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        <br>
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        <p><a href="https://2017.igem.org/Team:ETH_Zurich/Description" class="more"> BACKGROUND</a></p>
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    </div>
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</section>
  
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<div class="column full_size" >
 
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<h1> Welcome to iGEM 2017! </h1>
 
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
 
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</div>
 
  
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<div class="clear"></div>
 
  
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<section id="second" class="step">
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<h5>Before you start: </h5>
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    <div class="vision">
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<p> Please read the following pages:</p>
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<figure class="EcN">
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<ul>
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        <img src="https://static.igem.org/mediawiki/2017/0/02/T--ETH_Zurich--Ec.png">
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<li>  <a href="https://2017.igem.org/Competition">Competition Hub</a> </li>
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</figure>
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<li> <a href="https://2017.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
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<br>
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<li> <a href="https://2017.igem.org/Resources/Template_Documentation">Template documentation</a></li>
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<br>
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</ul>
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    <h1>VISION</h1>
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</div>
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        <p>To tackle the challenge of treating cancer, we decided to look beyond classical approaches and from the point of view of a synthetic biologist. </p>
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        <p>Our search led us to the concept of bacterial cancer therapy.</p>
 +
        <br>
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        <p><a href="https://2017.igem.org/Team:ETH_Zurich/Description" class="more">STORY OF CATE</a></p>
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    </div>
  
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<div class="column half_size" >
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</section>
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<div class="highlight">
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<h5> Styling your wiki </h5>
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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<div class="space">
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</div>
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  &nbsp;
 
</div>
 
</div>
  
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<div class="column full_size" >
 
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<h5> Wiki template information </h5>
 
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2017.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
 
  
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</div>  
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<section id="third" class="step">
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    <div>
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        <p>CATE consists of the non-pathogenic bacterium <span class="bacterium">E. coli</span> Nissle that has the intrinsic ability to home preferentially in tumors.</p>
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        <p>It features two safety checkpoint mechanisms to ensure only tumor cells are damaged.</p>
 +
        <p>CATE is administered intravenously, travels through the blood and colonizes tumors. When enough bacteria have accumulated in the tumor, they make themselves visible and
 +
      start preparing the cytotoxic payload.</p>
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        <p> After imaging the tumor with MRI, the doctor can then activate the release of the cancer-killing payload. </p>
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        <br>
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        <p><a href="https://2017.igem.org/Team:ETH_Zurich/Applied_Design" class="more">CATE IN ACTION</a></p>
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    </div>
  
  
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<figure class="process">
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  <img src="https://static.igem.org/mediawiki/2017/c/cf/T--ETH_Zurich--process.png">
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</figure>
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</section>
  
  
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<div class="column half_size" >
 
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<h5> Editing your wiki </h5>
 
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
 
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<p> <a href="https://2017.igem.org/wiki/index.php?title=Team:Example&action=edit"> </a>Use WikiTools - Edit in the black menu bar to edit this page</p>
 
  
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<div class="space">
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  &nbsp;
 
</div>
 
</div>
  
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<section id="fourth" class="step">
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<div class="circuit">
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<br>
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<br>
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<br>
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<figure class="andgate">
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  <img src="https://static.igem.org/mediawiki/2017/8/8c/T--ETH_Zurich--ANDgate.png">
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</figure>
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    <div>
  
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<div class="column half_size" >
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        <p>To achieve all these novel functions, we designed a genetic circuit that is distributed over two synthetic DNA sequences.</p>
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<h5>Tips</h5>
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        <p> All functions were tested and optimized to make the resulting circuit as safe and well-characterized as possible.</p>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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        <br>
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<ul>
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      <p><a href="https://2017.igem.org/Team:ETH_Zurich/Circuit" class="more">CIRCUIT</a></p>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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    </div>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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</section>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2017.igem.org/Calendar">iGEM 2017 calendar</a> </li>
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<li>Have lots of fun! </li>
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</ul>
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</div>
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<div class="column half_size" >
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<section id="fifth" class="step">
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<h5>Inspiration</h5>
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<div class="drylab">
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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<figure class="drylab">
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<ul>
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  <img src="https://static.igem.org/mediawiki/2017/0/0b/T--ETH_Zurich--dry_lab.png">
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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</figure>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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<br>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<h1>ENGINEERING</h1>
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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        <p>We increased the understanding of the system's underlying mathematics by simulating its behavior with our models.</p><p> The models were then used to define important questions to clarify in experiments and develop efficient experimental and genetic design strategies.</p>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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        <br>
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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        <p><a href="https://2017.igem.org/Team:ETH_Zurich/Model" class="more">DRY LAB</a></p>
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</ul>
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  </div>
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</div>
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</section>
  
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<div class="column half_size" >
 
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<h5> Uploading pictures and files </h5>
 
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<p> You can upload your pictures and files to the iGEM 2017 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
 
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When you upload, set the "Destination Filename" to <br><code>T--YourOfficialTeamName--NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)<br><br>
 
  
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<a href="https://2017.igem.org/Special:Upload">
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<section>
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UPLOAD FILES
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    <div class="wetlab">
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</a>
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<figure class="wetlab">
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</p>
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  <img src="https://static.igem.org/mediawiki/2017/9/95/T--ETH_Zurich--wetlab.png">
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</div>
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</figure>
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</div>
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<br>
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        <p>Experimentally, we collected data to support and refine our models and to show that our system works.</p>
 +
        <br>
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        <p><a href="https://2017.igem.org/Team:ETH_Zurich/Experiments" class="more">WET LAB</a></p>
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    </div>
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</section>
  
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</html>
 
  
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{{Team:ETH_Zurich/ETHZ_footer}}
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<section>
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    <div class="goals">
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<figure class="goals">
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    <img src="https://static.igem.org/mediawiki/2017/8/83/T--ETH_Zurich--achievementslanding.png">
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</figure>
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    <h1>ACHIEVEMENTS</h1>
 +
        <p>We could experimentally confirm the predictions of the models. After testing every function individually, we combined them one after the other in milestone experiments to show the system in action.</p> <p> We created and characterized new BioBrick parts as a contribution for the synthetic biology community.</p>
 +
        <br>
 +
        <p><a href="https://2017.igem.org/Team:ETH_Zurich/Results" class="more">ACHIEVEMENTS</a></p>
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    </div>
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</section>
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<section>
 +
  <div class="HP">
 +
    <h1>HUMAN PRACTICES</h1>
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<figure class="HP">
 +
    <img src="https://static.igem.org/mediawiki/2017/4/4a/T--ETH_Zurich--HPlanding.png">
 +
</figure>
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        <p>We went beyond the lab and reached out to experts to better understand current technological and safety issues in order to enhance the design of our project.</p><p> Further, we         
 +
        introduced our project and the field of synthetic biology to the general public and together explored issues related to safety, ethics and sustainability.</p>
 +
        <br>
 +
        <p><a href="https://2017.igem.org/Team:ETH_Zurich/Human_Practices" class="more">HUMAN PRACTICES</a></p>
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    </div>
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</section>
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<section>
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    <div class="team">
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<figure class="team">
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    <img src="https://static.igem.org/mediawiki/2017/e/ec/T--ETH_Zurich--teamlanding.png">
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</figure>
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    <h1>TEAM</h1>
 +
        <p>We are an interdisciplinary team of eight master students of ETH Zürich who compete in the iGEM championship against hundreds of other teams from all over the world.</p>
 +
        <br>
 +
        <p><a href="https://2017.igem.org/Team:ETH_Zurich/Team" class="more">TEAM</a></p>
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{{ETH_Zurich/Footer_N}}

Latest revision as of 14:06, 14 December 2017

WHY

Cancer kills over 8 million people every year. That's as much as the entire population of Switzerland!

We need more specific therapies because current approaches result in many side-effects. That's why we invented CATE, the first all-in-one living cancer therapeutic with an integrated two-step safety mechanism.

A living cure to a living disease!


BACKGROUND



VISION

To tackle the challenge of treating cancer, we decided to look beyond classical approaches and from the point of view of a synthetic biologist.

Our search led us to the concept of bacterial cancer therapy.


STORY OF CATE

 

CATE consists of the non-pathogenic bacterium E. coli Nissle that has the intrinsic ability to home preferentially in tumors.

It features two safety checkpoint mechanisms to ensure only tumor cells are damaged.

CATE is administered intravenously, travels through the blood and colonizes tumors. When enough bacteria have accumulated in the tumor, they make themselves visible and start preparing the cytotoxic payload.

After imaging the tumor with MRI, the doctor can then activate the release of the cancer-killing payload.


CATE IN ACTION

 



To achieve all these novel functions, we designed a genetic circuit that is distributed over two synthetic DNA sequences.

All functions were tested and optimized to make the resulting circuit as safe and well-characterized as possible.


CIRCUIT


ENGINEERING

We increased the understanding of the system's underlying mathematics by simulating its behavior with our models.

The models were then used to define important questions to clarify in experiments and develop efficient experimental and genetic design strategies.


DRY LAB


Experimentally, we collected data to support and refine our models and to show that our system works.


WET LAB

ACHIEVEMENTS

We could experimentally confirm the predictions of the models. After testing every function individually, we combined them one after the other in milestone experiments to show the system in action.

We created and characterized new BioBrick parts as a contribution for the synthetic biology community.


ACHIEVEMENTS

HUMAN PRACTICES

We went beyond the lab and reached out to experts to better understand current technological and safety issues in order to enhance the design of our project.

Further, we introduced our project and the field of synthetic biology to the general public and together explored issues related to safety, ethics and sustainability.


HUMAN PRACTICES

TEAM

We are an interdisciplinary team of eight master students of ETH Zürich who compete in the iGEM championship against hundreds of other teams from all over the world.


TEAM