Difference between revisions of "Team:HZAU-China/Project/Description"

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         that the whole system can be more safe and controlable. taking these into consider, we decided to use CRISPRi to
 
         that the whole system can be more safe and controlable. taking these into consider, we decided to use CRISPRi to
 
         inhibit its cell cycle, for more details please see design.</a>
 
         inhibit its cell cycle, for more details please see design.</a>
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       <a class="zhengwen">But barely pause the replication in some circumstance can't satisfy our needs, and long time inhibition will prolong
 
       <a class="zhengwen">But barely pause the replication in some circumstance can't satisfy our needs, and long time inhibition will prolong
 
         its length, so there is a need to totally control its replication, not only block but also open. with that purpose
 
         its length, so there is a need to totally control its replication, not only block but also open. with that purpose
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         which can be called 4C.</a>
 
         which can be called 4C.</a>
 
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Revision as of 14:28, 25 October 2017

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The replication process of E.coli replication can be devided into phase B,C and D, three phases. Phase B, also called pre-replication phase, is for DNA replication proparation similar as G1 phase in eukaryote cell cycle. Phase C is regarded as replication phase during which the chromosome is replicating corespond to the S phase in eukaryote. The last phase, phase D, is called post-replication phase, in which the behave of chromosome seperation and cell division happend just like what happened in G2 and M phase of eukaryote cells. the time of C phase and D phase in a generation is relative constant, so what actually determines the cell cycle is the initiation of genome replication. We know that cell have to garantee that each cell should have at least one chormosome, and this requires a highly coordination between DNA replication and cell divsion. Though the delicate mechanism of the corrdination is still a puzzle, it is clear that DnaA protein plays a significant role in this event. DnaA is a versatile protein, it can not only behave like a helicase opening the duble-helix of replication initiation site, OriC, while have the function of raising other proteins forming into the replisome to prolong the replication, but also can anchor the replicationg choromosome on the cell membrane leading the following seperation of chromosome. But what makes it the linker between replication and division is that its concentration determines the initiation volume of replication. So according to these information, we think that regulating the combination of DNA and DnaA protein will be an efficient method to regulate cell replication. For more information please click here.