Difference between revisions of "Team:Pittsburgh/Model"
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| + | We focused on modeling the chemotactic response of E. coli and the effects photoswitchable Dronpa has on bacterial motility. When wild type E. coli are exposed to a chemical repellant, the main chemotaxis protein CheY will become phosphorylated by the autophosphorylated CheA. Next, the now phosphorylated CheY, (CheY~P) will be able to bind with high affinity to FliM, one of the proteins in the flagellar motor. This interaction between CheY~P and FliM is one of the main determinants behind the swimming versus tumbling behavior in bacteria. | ||
| + | We wanted to investigate this system because it is possible to compare the modeling results with experimental data obtained through microscopy videos. In addition, since the chemotaxis system has many aspects such as the reaction rates of kinase activity that we may not have considered, the model can give us more insight on potential research areas. Because our model is clearly based on certain rules that govern the interaction between the different chemotaxis proteins, we are able to use Rule Based Modeling.> | ||
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Revision as of 01:05, 2 November 2017
Modeling
Mathematical models and computer simulations provide a great way to describe the function and operation of BioBrick Parts and Devices. Synthetic Biology is an engineering discipline, and part of engineering is simulation and modeling to determine the behavior of your design before you build it. Designing and simulating can be iterated many times in a computer before moving to the lab. This award is for teams who build a model of their system and use it to inform system design or simulate expected behavior in conjunction with experiments in the wetlab.
Gold Medal Criterion #3
To complete for the gold medal criterion #3, please describe your work on this page and fill out the description on your judging form. To achieve this medal criterion, you must convince the judges that your team has gained insight into your project from modeling. You may not convince the judges if your model does not have an effect on your project design or implementation.
Please see the 2017 Medals Page for more information.
Best Model Special Prize
To compete for the Best Model prize, please describe your work on this page and also fill out the description on the judging form. Please note you can compete for both the gold medal criterion #3 and the best model prize with this page.
You must also delete the message box on the top of this page to be eligible for the Best Model Prize.
Inspiration
Here are a few examples from previous teams:
