Difference between revisions of "Team:TP-CC San Diego"

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   width: 60%;
 
   width: 60%;
 
}
 
}
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                #outer{
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height: 400px;
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width: 100%;
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background-image: url(https://static.igem.org/mediawiki/2016/b/b0/Tpcc-homesection1.jpg);
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background-size: cover;
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margin: 0px 0px 40px 0px;
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}
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#outerRight{
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height: 400px;
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width: 100%;
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background-image: url(https://static.igem.org/mediawiki/2016/e/e6/Tpcc-homesection2.jpg);
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background-size: cover;
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margin: 20px 0px 20px 0px;
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}
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#inner{
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width: 1100px;
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height: 400px;
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overflow: hidden;
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margin: 0 auto 0 auto;
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}
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#finalinner{
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width: 250px;
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height: 382px;
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float: left;
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background-color: white;
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padding: 18px 75px 0 35px;
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background-color: #f2f2f2;
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}
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#finalinnerRight{
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width: 250px;
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height: 382px;
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float: right;
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background-color: white;
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padding: 18px 35px 0 75px;
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text-align: right;
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background-color: #f2f2f2;
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}
  
 
</style>
 
</style>
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<body>
 
<body>
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<div id="outer">
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<div id="inner">
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<div id="finalinner">
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<h2 style="margin-bottom: 0px;">PROJECT OVERVIEW</h2>
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<div id="borderBot"></div><br><br>
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<p style="margin-bottom: 15px;">
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Around the world, fungal diseases are decimating crop yields and hindering agricultral efficiency. Our project seeks to create a safe, natural fungicide through the bacterial secretion of chitinase. This year we have made updates to our plasmid from last year.
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</p>
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<a href="https://2016.igem.org/Team:TP_CC_SanDiego/Description">FIND OUT MORE</a>
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</div>
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</div>
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</div>
 
<h2 class = "main-title" style="margin-top: 390px;">ecDNA</h2>
 
<h2 class = "main-title" style="margin-top: 390px;">ecDNA</h2>
  

Revision as of 03:32, 11 October 2017


PROJECT OVERVIEW



Around the world, fungal diseases are decimating crop yields and hindering agricultral efficiency. Our project seeks to create a safe, natural fungicide through the bacterial secretion of chitinase. This year we have made updates to our plasmid from last year.

FIND OUT MORE

ecDNA

Cancer, a genetic disease resulting in uncontrollable cell growth, is mostly caused by somatic mutations acquired throughout an individual’s lifetime. Because it induces the increased expression of growth related genes, oncogene amplification is one of the driving forces of cancer cell replication. Recently, it was discovered that some oncogenes resided on extrachromosomal DNA (ecDNA). Like the DNA on chromosomes, ecDNAs are double stranded. A key difference, however, is the circular shape of ecDNAs; they are able to randomly distribute because they do not have centromeres, which increases heterogeneity in daughter cells. This can cause the cancerous tumors to develop faster resistance to current treatments. To target the ecDNA, we used CRISPR technology to create double strand breaks specifically in the ecDNA. Because ecDNA causes oncogene copy number to increase exponentially, utilizing CRISPR to create breaks in ecDNA decreases cancer cells’ replication speed.