Difference between revisions of "Team:TP-CC San Diego"
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Cancer, a genetic disease resulting in uncontrollable cell growth, is mostly caused by somatic mutations acquired throughout an individual’s lifetime. Recently, it was discovered that some oncogenes resided on extrachromosomal DNA (ecDNA). Because ecDNA causes oncogene copy number to increase exponentially, utilizing CRISPR to create breaks in ecDNA decreases cancer cells’ replication speed. | Cancer, a genetic disease resulting in uncontrollable cell growth, is mostly caused by somatic mutations acquired throughout an individual’s lifetime. Recently, it was discovered that some oncogenes resided on extrachromosomal DNA (ecDNA). Because ecDNA causes oncogene copy number to increase exponentially, utilizing CRISPR to create breaks in ecDNA decreases cancer cells’ replication speed. | ||
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| − | <a href="https://2017.igem.org/Team:TP-CC_San_Diego/Description"><span style="background-color: blue; padding: 2px;">FIND OUT MORE</span></a> | + | <a href="https://2017.igem.org/Team:TP-CC_San_Diego/Description"><span style="background-color: blue; padding: 2px; box-shadow: 0 0 0 5px black;">FIND OUT MORE</span></a> |
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Revision as of 03:52, 11 October 2017
PROJECT OVERVIEW
Cancer, a genetic disease resulting in uncontrollable cell growth, is mostly caused by somatic mutations acquired throughout an individual’s lifetime. Recently, it was discovered that some oncogenes resided on extrachromosomal DNA (ecDNA). Because ecDNA causes oncogene copy number to increase exponentially, utilizing CRISPR to create breaks in ecDNA decreases cancer cells’ replication speed.
FIND OUT MOREecDNA
Cancer, a genetic disease resulting in uncontrollable cell growth, is mostly caused by somatic mutations acquired throughout an individual’s lifetime. Because it induces the increased expression of growth related genes, oncogene amplification is one of the driving forces of cancer cell replication. Recently, it was discovered that some oncogenes resided on extrachromosomal DNA (ecDNA). Like the DNA on chromosomes, ecDNAs are double stranded. A key difference, however, is the circular shape of ecDNAs; they are able to randomly distribute because they do not have centromeres, which increases heterogeneity in daughter cells. This can cause the cancerous tumors to develop faster resistance to current treatments. To target the ecDNA, we used CRISPR technology to create double strand breaks specifically in the ecDNA. Because ecDNA causes oncogene copy number to increase exponentially, utilizing CRISPR to create breaks in ecDNA decreases cancer cells’ replication speed.
