Difference between revisions of "Team:TP-CC San Diego"

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{{TP-CC_San_Diego}}
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{{:Team:TP-CC_San_Diego/Templates/NavBar}}
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{{:Team:TP-CC San Diego/Templates/Font}}
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{{:Team:TP-CC_San_Diego/Templates/AnimationCSS}}
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<html>
 
<html>
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<head>
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<title>Home</title>
  
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<link href="https://cdn.rawgit.com/michalsnik/aos/2.1.1/dist/aos.css" rel="stylesheet">
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<script src="https://cdn.rawgit.com/michalsnik/aos/2.1.1/dist/aos.js"></script>
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<script>
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    AOS.init();
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</script>
  
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<div class="column full_size" >
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<style>
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<img src="http://placehold.it/2000x300/d3d3d3/f2f2f2">
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</div>
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.main-title {
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  padding: 40px 80px 40px 80px;
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  font-size: 50px;
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  padding-top: 6%;
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}
  
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.fade-in{
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  animation: opac 2s
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}
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@keyframes opac{
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from{opacity:0}
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to{opacity:1}}
  
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<div class="column full_size" >
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.icon-wrapper
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<h1> Welcome to iGEM 2017! </h1>
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{
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<p>Your team has been approved and you are ready to start the iGEM season! </p>
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  display: inline-block;
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</div>
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  margin: 1%;
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}
  
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<div class="clear"></div>
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.icon
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{
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  width:  100%;
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  height: 100%;
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  margin: 0 auto auto auto;
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}
  
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<div class="column half_size" >
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.icon img
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<h5>Before you start: </h5>
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{
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<p> Please read the following pages:</p>
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  position: block;
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<ul>
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  width: 100%;
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<li>  <a href="https://2017.igem.org/Competition">Competition Hub</a> </li>
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  height: 100%;
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<li> <a href="https://2017.igem.org/Competition/Deliverables/Wiki">Wiki Requirements page</a></li>
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}
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<li> <a href="https://2017.igem.org/Resources/Template_Documentation">Template documentation</a></li>
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</ul>
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</div>
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<div class="column half_size" >
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.icon-wrapper h3
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<div class="highlight">
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{
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<h5> Styling your wiki </h5>
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  position: relative;
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<p>You may style this page as you like or you can simply leave the style as it is. You can easily keep the styling and edit the content of these default wiki pages with your project information and completely fulfill the requirement to document your project.</p>
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  margin: auto;
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<p>While you may not win Best Wiki with this styling, your team is still eligible for all other awards. This default wiki meets the requirements, it improves navigability and ease of use for visitors, and you should not feel it is necessary to style beyond what has been provided.</p>
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  top: -15%;
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</div>
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  text-align: center;
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</div>
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}
  
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<div class="column full_size" >
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.imageDiv
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<h5> Wiki template information </h5>
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{
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<p>We have created these wiki template pages to help you get started and to help you think about how your team will be evaluated. You can find a list of all the pages tied to awards here at the <a href="https://2017.igem.org/Judging/Pages_for_Awards">Pages for awards</a> link. You must edit these pages to be evaluated for medals and awards, but ultimately the design, layout, style and all other elements of your team wiki is up to you!</p>
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    display: inline-block;
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}
  
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</div>
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.info
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{
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  margin: 2% auto auto auto;
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  font-size: 20px;
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  font-family: 'Poppins', sans-serif;
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  color: black;
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  text-align: center;
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}
  
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.banner
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{
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  padding-top: -1%;
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}
  
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.text-wrapper1
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{
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    background: none;
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    margin: 80px 0px 0px 2%;
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    padding: 2% 2% 2% 2%;
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    width: 80%;
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    height: 100%;
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    margin: auto;
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}
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</style>
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</head>
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<body>
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<center>
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<div class="banner">
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<img style="width: 100%;margin: auto auto .5% auto;" src="https://static.igem.org/mediawiki/2017/archive/1/11/20171029225547%21T--TP-CC_San_Diego--banner.png">
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</div>
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</center>
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<!--<center>
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<h2 class = "main-title fade-in" style="margin: 5% 0 5% 0;">ecDNA</h2>
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-->
  
  
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<div class="column half_size" >
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<div class="text-wrapper1">
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<h5> Editing your wiki </h5>
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  <h3 class="day" style="margin-top: 2%;">Abstract</h3>
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<p>On this page you can document your project, introduce your team members, document your progress and share your iGEM experience with the rest of the world! </p>
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<p style="font-size: 22px; margin-top: 20px;">
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<p> <a href="https://2017.igem.org/wiki/index.php?title=Team:Example&action=edit"> </a>Use WikiTools - Edit in the black menu bar to edit this page</p>
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Cancer, a genetic disease resulting in uncontrollable cell growth, is mostly caused by somatic mutations acquired throughout an individual’s lifetime. Because it induces the increased expression of growth related genes, oncogene amplification is one of the driving forces of cancer cell replication. Recently, it was discovered that some oncogenes resided on extrachromosomal DNA (ecDNA). Like the DNA on chromosomes, ecDNAs are double stranded. A key difference, however, is the circular shape of ecDNAs; they are able to randomly distribute because they do not have centromeres, which increases heterogeneity in daughter cells. This can cause the cancerous tumors to develop faster resistance to current treatments. To target the ecDNA, we used CRISPR technology to create double strand breaks specifically in the ecDNA. Because ecDNA causes oncogene copy number to increase exponentially, utilizing CRISPR to create breaks in ecDNA decreases cancer cells’ replication speed.
  
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</p>
 
</div>
 
</div>
  
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<center>
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<div style="margin-top: 2%;">
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<div class="icon-wrapper ih-item circle effect10 top_to_bottom"><a href="https://2017.igem.org/Team:TP-CC_San_Diego/Description">
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        <div class="icon-wrapper img"><img src="https://static.igem.org/mediawiki/2017/archive/e/e4/20171023064510%21T--TP-CC_San_Diego--brain.png" width = "250"></div>
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        <div class="info">
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        <h3 class = "page-title">Project Description</h3>
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        </div></a>
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</div>
  
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<div class="column half_size" >
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<div class="icon-wrapper ih-item circle effect10 top_to_bottom"><a href="https://2017.igem.org/Team:TP-CC_San_Diego/Results">
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<h5>Tips</h5>
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        <div class="icon-wrapper img"><img src="https://static.igem.org/mediawiki/2017/archive/e/e1/20171023064527%21T--TP-CC_San_Diego--beaker.png" width = "250"></div>
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<p>This wiki will be your team’s first interaction with the rest of the world, so here are a few tips to help you get started: </p>
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        <div class="info">
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<ul>
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      <h3 class = "page-title">Results</h3>
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<li>State your accomplishments! Tell people what you have achieved from the start. </li>
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        </div></a>
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<li>Be clear about what you are doing and how you plan to do this.</li>
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<li>You have a global audience! Consider the different backgrounds that your users come from.</li>
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<li>Make sure information is easy to find; nothing should be more than 3 clicks away.  </li>
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<li>Avoid using very small fonts and low contrast colors; information should be easy to read.  </li>
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<li>Start documenting your project as early as possible; don’t leave anything to the last minute before the Wiki Freeze. For a complete list of deadlines visit the <a href="https://2017.igem.org/Calendar">iGEM 2017 calendar</a> </li>
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<li>Have lots of fun! </li>
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</ul>  
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</div>
 
</div>
  
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<div class="icon-wrapper ih-item circle effect10 top_to_bottom"><a href="https://2017.igem.org/Team:TP-CC_San_Diego/Model">
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        <div class="icon-wrapper img"><img src="https://static.igem.org/mediawiki/2017/archive/6/6a/20171023064653%21T--TP-CC_San_Diego--graph.png" width = "250"></div>
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        <div class="info">
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      <h3 class = "page-title">Modeling</h3>
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        </div></a>
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</div>
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</div>
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</center>
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<center>
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<div class="icon-wrapper ih-item circle effect10 top_to_bottom"><a href="https://2017.igem.org/Team:TP-CC_San_Diego/LabBook">
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        <div class="icon-wrapper img"><img src="https://static.igem.org/mediawiki/2017/archive/d/d7/20171023064353%21T--TP-CC_San_Diego--book.png" width = "250"></div>
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        <div class="info">
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      <h3 class = "page-title">Lab Notebook</h3>
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        </div></a>
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</div>
  
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<div class="column half_size" >
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<div class="icon-wrapper ih-item circle effect10 top_to_bottom"><a href="https://2017.igem.org/Team:TP-CC_San_Diego/InterLab">
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<h5>Inspiration</h5>
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        <div class="icon-wrapper img"><img src="https://static.igem.org/mediawiki/2017/archive/2/2d/20171023064557%21T--TP-CC_San_Diego--cell.png" width = "250"></div>
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<p> You can also view other team wikis for inspiration! Here are some examples:</p>
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        <div class="info">
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<ul>
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      <h3 class = "page-title">Interlab Study</h3>
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<li> <a href="https://2014.igem.org/Team:SDU-Denmark/"> 2014 SDU Denmark </a> </li>
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        </div></a>
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<li> <a href="https://2014.igem.org/Team:Aalto-Helsinki">2014 Aalto-Helsinki</a> </li>
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</div>
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<li> <a href="https://2014.igem.org/Team:LMU-Munich">2014 LMU-Munich</a> </li>
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<div class="icon-wrapper ih-item circle effect10 top_to_bottom"><a href="https://2017.igem.org/Team:TP-CC_San_Diego/Protocols">
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<li> <a href="https://2014.igem.org/Team:Michigan"> 2014 Michigan</a></li>
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        <div class="icon-wrapper img"><img src="https://static.igem.org/mediawiki/2017/archive/0/03/20171023064720%21T--TP-CC_San_Diego--magnifying.png" width = "250"></div>
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<li> <a href="https://2014.igem.org/Team:ITESM-Guadalajara">2014 ITESM-Guadalajara </a></li>
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        <div class="info">
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<li> <a href="https://2014.igem.org/Team:SCU-China"> 2014 SCU-China </a></li>
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      <h3 class = "page-title">Protocols</h3>
−
</ul>
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        </div></a>
 +
</div>
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</center>
 +
   
 +
<center>
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<div class="icon-wrapper ih-item circle effect10 top_to_bottom"><a href="https://2017.igem.org/Team:TP-CC_San_Diego/MedalCriteria">
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        <div class="icon-wrapper img"><img src="https://static.igem.org/mediawiki/2017/archive/4/4a/20171023064737%21T--TP-CC_San_Diego--medal.png" width = "250"></div>
 +
        <div class="info">
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      <h3 class = "page-title">Medal Criteria</h3>
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        </div></a>
 
</div>
 
</div>
  
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<div class="column half_size" >
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<div class="icon-wrapper ih-item circle effect10 top_to_bottom"><a href="https://2017.igem.org/Team:TP-CC_San_Diego/HumanPractices">
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<h5> Uploading pictures and files </h5>
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        <div class="icon-wrapper img"><img src="https://static.igem.org/mediawiki/2017/archive/e/e7/20171023064751%21T--TP-CC_San_Diego--podium.png" width = "250"></div>
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<p> You can upload your pictures and files to the iGEM 2017 server. Remember to keep all your pictures and files within your team's namespace or at least include your team's name in the file name. <br />
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        <div class="info">
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When you upload, set the "Destination Filename" to <br><code>T--YourOfficialTeamName--NameOfFile.jpg</code>. (If you don't do this, someone else might upload a different file with the same "Destination Filename", and your file would be erased!)<br><br>
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      <h3 class = "page-title">Human Practices</h3>
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        </div></a>
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</div>
  
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<a href="https://2017.igem.org/Special:Upload">
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<div class="icon-wrapper ih-item circle effect10 top_to_bottom"><a href="https://2017.igem.org/Team:TP-CC_San_Diego/Team">
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UPLOAD FILES
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        <div class="icon-wrapper img"><img src="https://static.igem.org/mediawiki/2017/archive/e/e7/20171023064541%21T--TP-CC_San_Diego--ecdnagroup.png" width = "250"></div>
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</a>
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        <div class="info">
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</p>
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      <h3 class = "page-title">Team</h3>
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        </div></a>
 
</div>
 
</div>
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</center>
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</body>
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</html>
 
</html>

Latest revision as of 00:04, 2 November 2017

Home

Abstract

Cancer, a genetic disease resulting in uncontrollable cell growth, is mostly caused by somatic mutations acquired throughout an individual’s lifetime. Because it induces the increased expression of growth related genes, oncogene amplification is one of the driving forces of cancer cell replication. Recently, it was discovered that some oncogenes resided on extrachromosomal DNA (ecDNA). Like the DNA on chromosomes, ecDNAs are double stranded. A key difference, however, is the circular shape of ecDNAs; they are able to randomly distribute because they do not have centromeres, which increases heterogeneity in daughter cells. This can cause the cancerous tumors to develop faster resistance to current treatments. To target the ecDNA, we used CRISPR technology to create double strand breaks specifically in the ecDNA. Because ecDNA causes oncogene copy number to increase exponentially, utilizing CRISPR to create breaks in ecDNA decreases cancer cells’ replication speed.

Lab Notebook

Interlab Study

Protocols

Medal Criteria

Human Practices

Team