Lukas Adam (Talk | contribs) |
Lukas Adam (Talk | contribs) |
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− | |||
<html lang="en" dir="ltr" class="client-nojs"> | <html lang="en" dir="ltr" class="client-nojs"> | ||
<head> | <head> | ||
− | + | <meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes"> | |
− | <meta name="viewport" content="width=device-width, initial-scale=1.0" | + | |
− | + | ||
− | + | ||
<meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> | <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> | ||
<meta name="generator" content="MediaWiki 1.16.5" /> | <meta name="generator" content="MediaWiki 1.16.5" /> | ||
Line 118: | Line 114: | ||
} | } | ||
</style> | </style> | ||
+ | <link rel="stylesheet" type="text/css" href="https://2017.igem.org/Template:Heidelberg/jasnybootstrapmin/CSS?action=raw&ctype=text/css" /> | ||
+ | <script src="https://2017.igem.org/Template:Heidelberg/bootstrapmin/JS?action=raw&ctype=text/javascript"></script> | ||
+ | |||
− | |||
− | |||
− | |||
<!-- Assets --> | <!-- Assets --> | ||
− | <link rel="stylesheet" href=" | + | <link rel="stylesheet" href="https://2017.igem.org/Template:Heidelberg/tilda-grid/CSS?action=raw&ctype=text/css" type="text/css" media="all" /> |
+ | <link rel="stylesheet" href="https://2017.igem.org/Template:Heidelberg/mdl-teal/CSS?action=raw&ctype=text/css" type="text/css" media="all" /> | ||
− | |||
<link rel="stylesheet" href="https://fonts.googleapis.com/css?family=Josefin+Sans:300,400|Roboto:300,400,500"> | <link rel="stylesheet" href="https://fonts.googleapis.com/css?family=Josefin+Sans:300,400|Roboto:300,400,500"> | ||
− | <link rel="stylesheet" | + | <link rel="stylesheet" type="text/css" href="https://2017.igem.org/Template:Heidelberg/bootstrapmin/CSS?action=raw&ctype=text/css" /> |
− | + | <link rel="stylesheet" type="text/css" href="https://2017.igem.org/Template:Heidelberg/styles/CSS?action=raw&ctype=text/css" /> | |
− | <link href="https:// | + | |
− | <link rel="stylesheet" href=" | + | <link href="https://fonts.googleapis.com/css?family=Open+Sans" rel="stylesheet"> |
+ | <link rel="stylesheet" type="text/css" href="https://2017.igem.org/Template:Heidelberg/font-icons/CSS?action=raw&ctype=text/css"/> | ||
+ | |||
+ | |||
+ | <style> | ||
+ | #sidebarCollapse { | ||
+ | background-color: white; | ||
+ | border: none; | ||
+ | } | ||
+ | |||
+ | |||
+ | |||
+ | /* Enlarge Icons on hover */ | ||
+ | .toolbox-icon-scale:hover { | ||
+ | transform: scale(1.15); | ||
+ | -webkit-transform: scale(1.15); | ||
+ | -moz-transform: scale(1.15); | ||
+ | -o-transform: scale(1.15); | ||
+ | -ms-transform: scale(1.15); | ||
+ | } | ||
+ | |||
+ | .toolbox-icon-scale { | ||
+ | transition:transform 0.15s ease; | ||
+ | -webkit-transition:-webkit-transform 0.15s ease; | ||
+ | -moz-transition:-moz-transform 0.15s ease; | ||
+ | -o-transition:-o-transform 0.15s ease; | ||
+ | } | ||
+ | |||
+ | |||
+ | .abstract-special { | ||
+ | color: white; | ||
+ | } | ||
+ | |||
+ | |||
+ | |||
+ | |||
+ | |||
+ | |||
+ | #box1 { | ||
+ | position: absolute; | ||
+ | left: 110px; | ||
+ | top: 395px; | ||
+ | width: 150px; | ||
+ | } | ||
+ | |||
+ | |||
+ | |||
+ | #box2 { | ||
+ | position: absolute; | ||
+ | left: 90px; | ||
+ | top: 455px; | ||
+ | width: 260px; | ||
+ | float: left; | ||
+ | |||
+ | } | ||
+ | |||
+ | |||
+ | #box3 { | ||
+ | position: absolute; | ||
+ | left: 330px; | ||
+ | top: 450px; | ||
+ | width: 160px; | ||
+ | } | ||
+ | |||
+ | |||
+ | #box4 { | ||
+ | position: absolute; | ||
+ | left: 590px; | ||
+ | top: 510px; | ||
+ | width: 120px; | ||
+ | } | ||
+ | |||
+ | |||
+ | #box5 { | ||
+ | position: absolute; | ||
+ | left: 740px; | ||
+ | top: 453px; | ||
+ | width: 100px; | ||
+ | } | ||
+ | |||
+ | #icon-text { | ||
+ | position: absolute; | ||
+ | right: 550px; | ||
+ | top: 150px; | ||
+ | width:220px; | ||
+ | } | ||
+ | |||
+ | .graphicalAbstract { | ||
+ | position:relative; | ||
+ | z-index: 1; | ||
+ | height:750px; | ||
+ | } | ||
+ | |||
+ | |||
+ | |||
+ | svg{ | ||
+ | width:100%; | ||
+ | margin:0 auto; | ||
+ | padding: 5px; | ||
+ | |||
+ | |||
+ | } | ||
+ | .hex{ | ||
+ | stroke-width:5; | ||
+ | stroke: white; | ||
+ | fill-opacity:1; | ||
+ | transition:fill-opacity .8s; | ||
+ | |||
+ | } | ||
+ | |||
+ | |||
+ | |||
+ | |||
+ | |||
+ | #icon-text > p { | ||
+ | color: white !important; | ||
+ | } | ||
+ | |||
+ | #text{ | ||
+ | stroke-width:0; | ||
+ | stroke:white; | ||
+ | fill:white; | ||
+ | font-family: 'Josefin Sans' !important, sans-serif; | ||
+ | } | ||
+ | #hex:hover + #text{ | ||
+ | fill-opacity:1; | ||
+ | } | ||
+ | |||
+ | canvas{ | ||
+ | display:block; background:transparent; | ||
+ | position: absolute;bottom: 78px; right: 5px; | ||
+ | } | ||
+ | |||
+ | </style> | ||
+ | <style> | ||
+ | |||
+ | #box1:hover #path4572, #box1:hover #path4576 { | ||
+ | fill: #b3dede !important; | ||
+ | transition: all 0.2s ease; | ||
+ | } | ||
+ | #box1:hover #path4579, #box1:hover #path4581, #box1:hover #path4583 { | ||
+ | stroke: #b3dede !important; | ||
+ | transition: all 0.2s ease; | ||
+ | } | ||
+ | |||
+ | #box2:hover #g5682, #box2:hover #path20-6, #box2:hover #path5684 { | ||
+ | fill: #fed699 !important; | ||
+ | transition: all 0.2s ease; | ||
+ | } | ||
+ | |||
+ | #box3:hover #path5656, #box3:hover #path6215, #box3:hover #path6219 , #box3:hover #path6221 , #box3:hover #path6223, #box3:hover #path6227, #box3:hover #circle6225,#box3:hover #circle6229, #box3:hover #circle6231, #box3:hover #circle6233, #box3:hover #circle6235 , #box3:hover #circle6237 , #box3:hover #circle6239,#box3:hover #circle6241, #box3:hover #circle6243, #box3:hover #circle6245, #box3:hover #circle6247, #box3:hover #path6233 { | ||
+ | fill: #d89f9c !important; | ||
+ | |||
+ | transition: all 0.2s ease; | ||
+ | } | ||
+ | |||
+ | #box3:hover #path6211, #box3:hover #path6215, #box3:hover #path6219, #box3:hover #path6223, #box3:hover #path6227, #box3:hover #path6233 { | ||
+ | stroke: #d89f9c !important; | ||
+ | |||
+ | transition: all 0.2s ease; | ||
+ | } | ||
+ | |||
+ | #box4:hover #path6582, #box4:hover #path6572{ | ||
+ | fill: #9AD5C3 !important; | ||
+ | |||
+ | transition: all 0.2s ease; | ||
+ | } | ||
+ | #box5:hover #path4587{ | ||
+ | fill: #b2cbdd !important; | ||
+ | |||
+ | transition: all 0.2s ease; | ||
+ | } | ||
+ | |||
+ | #box5:hover #path4593, #box5:hover #path5179, #box5:hover #path5181, #box5:hover #path5183, #box5:hover #path5185, #box5:hover #path5187, #box5:hover #path5189, #box5:hover #path5191, #box5:hover #path5193 { | ||
+ | stroke: #b2cbdd !important; | ||
+ | |||
+ | transition: all 0.2s ease; | ||
+ | } | ||
+ | |||
+ | .overall-wrapper { | ||
+ | min-width: 1300px !important; | ||
+ | overflow-x: scroll; | ||
+ | } | ||
+ | .icon-box { | ||
+ | position: absolute; | ||
+ | } | ||
+ | button { | ||
+ | background-color: #9d1c20 !important; | ||
+ | color: white !important; | ||
+ | border: none; | ||
+ | } | ||
+ | </style> | ||
− | |||
− | |||
<link rel="stylesheet" type="text/css" | <link rel="stylesheet" type="text/css" | ||
href="https://2017.igem.org/Template:Heidelberg/table_layout/CSS?action=raw&ctype=text/css" /> | href="https://2017.igem.org/Template:Heidelberg/table_layout/CSS?action=raw&ctype=text/css" /> | ||
<!-- Favicon and touch icons --> | <!-- Favicon and touch icons --> | ||
− | + | <script src="https://ajax.googleapis.com/ajax/libs/jquery/3.2.1/jquery.min.js"></script> | |
+ | |||
+ | |||
+ | |||
<script type="text/javascript" src="https://2015.igem.org/Template:Heidelberg/js/jasnybootstrapmin?action=raw&ctype=text/javascript"></script> | <script type="text/javascript" src="https://2015.igem.org/Template:Heidelberg/js/jasnybootstrapmin?action=raw&ctype=text/javascript"></script> | ||
− | |||
− | |||
− | < | + | <link href="https://maxcdn.bootstrapcdn.com/font-awesome/4.2.0/css/font-awesome.min.css" rel="stylesheet"> |
− | <script src=" | + | <script src="https://maxcdn.bootstrapcdn.com/bootstrap/3.3.7/js/bootstrap.min.js"></script> |
− | < | + | |
− | <script src=" | + | |
− | + | ||
− | + | ||
+ | <link rel="stylesheet" href="https://fonts.googleapis.com/css?family=Josefin+Sans:300,400|Roboto:300,400,500"> | ||
+ | |||
+ | |||
+ | <link rel="stylesheet" href="http://azmind.com/demo/bootstrap-navbar-menu/layout-3/assets/font-awesome/css/font-awesome.min.css"> | ||
+ | |||
+ | |||
+ | <!-- Favicon and touch icons --> | ||
+ | <script src="https://ajax.googleapis.com/ajax/libs/jquery/3.2.1/jquery.min.js"></script> | ||
+ | |||
+ | <script type="text/javascript" src="https://2017.igem.org/Template:Heidelberg/jasnybootstrapmin/JS?action=raw&ctype=text/javascript"></script> | ||
+ | |||
+ | |||
+ | |||
+ | <link href="https://maxcdn.bootstrapcdn.com/font-awesome/4.2.0/css/font-awesome.min.css" rel="stylesheet"> | ||
+ | |||
+ | |||
+ | </head> | ||
+ | <body class="t-body"> | ||
+ | |||
+ | <link href="https://fonts.googleapis.com/css?family=Quicksand:300,400|Roboto:400,400i" rel="stylesheet"> | ||
</head> | </head> | ||
− | |||
− | |||
− | |||
− | |||
<body class="t-body"> | <body class="t-body"> | ||
<!-- CSS --> | <!-- CSS --> | ||
Line 170: | Line 372: | ||
<div class="navbar-header"> | <div class="navbar-header"> | ||
− | <a class="navbar-brand" href="https://2017.igem.org/Team:Heidelberg | + | <a class="navbar-brand" href="https://2017.igem.org/Team:Heidelberg"><div id="circle"> |
</div></a> | </div></a> | ||
+ | <a type="button" data-canvas="body" id="sidebarCollapse" class="navbar-toggle" data-toggle="offcanvas" data-target="#sidebar" style="color: #393939;margin-top: 9px;">NAVIGATION | ||
+ | </a> | ||
</div> | </div> | ||
Line 223: | Line 427: | ||
<nav id="sidebar" style="background-color: white;border: none;box-shadow:1px 0px 0px #393939;" class="navmenu navmenu-default navmenu-fixed-left offcanvas" role="navigation"> | <nav id="sidebar" style="background-color: white;border: none;box-shadow:1px 0px 0px #393939;" class="navmenu navmenu-default navmenu-fixed-left offcanvas" role="navigation"> | ||
− | <a class="navmenu-brand" href=" | + | <a class="navmenu-brand" href="https://2017.igem.org/Team:Heidelberg"><img src="https://static.igem.org/mediawiki/2017/8/8f/Heidelberg_2017_phage_logo.svg"><br><br> iGEM TEAM HEIDELBERG 2017</a> |
<hr> | <hr> | ||
<ul class="nav navmenu-nav" id="sidenav"> | <ul class="nav navmenu-nav" id="sidenav"> | ||
Line 240: | Line 444: | ||
</ul> | </ul> | ||
</li> | </li> | ||
− | <li><a data-toggle="collapse" data-target="#AI_side">Software & Hardware <i class="fa fa-fw fa-caret-down"></i></a> | + | <li><a data-toggle="collapse" data-target="#AI_side">Software & Hardware <i class="fa fa-fw fa-caret-down"></i></a>our |
<ul id="AI_side" class="collapse side"> | <ul id="AI_side" class="collapse side"> | ||
<li><a href="https://2017.igem.org/Team:Heidelberg/Software">AI</a></li> | <li><a href="https://2017.igem.org/Team:Heidelberg/Software">AI</a></li> | ||
Line 269: | Line 473: | ||
</ul> | </ul> | ||
</nav> | </nav> | ||
− | + | <div class="page-title" style="color: #9d1c20 !important;padding-top: 100px;"> | |
− | + | <div class="t-container"> | |
− | + | <div class="t-col t-col_12"> | |
+ | <span id="header-subtitle" style="white-space: pre-line;"> Project Overview</span> | ||
+ | </div> | ||
+ | |||
+ | </div> | ||
+ | </div> | ||
+ | |||
+ | <div style="background-color:#393939;"> | ||
<div class="t-container"> | <div class="t-container"> | ||
− | + | <div class="t-col t-col_12"> | |
− | + | <div class="graphicalAbstract" style="overflow-x: auto;"> | |
− | + | ||
+ | <div style="z-index:3;position:relative; height:100%;width: 1150px !important;"> | ||
+ | <img src="https://static.igem.org/mediawiki/2017/f/f3/T--Heidelberg--2017_Description_Background.svg" style="width: 100%;position: absolute;left: 0px;"> | ||
+ | <?xml version="1.0" encoding="UTF-8" standalone="no"?> | ||
+ | <!-- Created with Inkscape (http://www.inkscape.org/) --> | ||
− | + | <canvas id='flagella'></canvas> | |
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | <div id="box1" class="icon-box"><?xml version="1.0" encoding="UTF-8" standalone="no"?> | |
− | + | <!-- Created with Inkscape (http://www.inkscape.org/) --> | |
− | + | ||
− | + | <svg | |
+ | width="100%" | ||
+ | height="auto" | ||
+ | viewBox="0 0 80 50" | ||
+ | version="1.1" | ||
+ | id="svg7594"> | ||
+ | <g | ||
+ | inkscape:label="Layer 1" | ||
+ | inkscape:groupmode="layer" | ||
+ | id="layer1" | ||
+ | transform="translate(0,-247)"> | ||
+ | <g | ||
+ | transform="matrix(0.32783362,0,0,0.28976156,-76.973977,51.046922)" | ||
+ | style="stroke-width:0.85845065" | ||
+ | id="g8144"> | ||
+ | <path | ||
+ | sodipodi:nodetypes="csccc" | ||
+ | inkscape:connector-curvature="0" | ||
+ | id="path4572" | ||
+ | d="m 285.88235,809.29011 c 12.6945,9.15823 44.97094,3.26696 39.60759,-3.84411 -20.08563,-26.63079 -20.05884,-30.75579 -3.81932,-63.76386 -18.61643,-22.78601 -44.55259,-5.15187 -50.12072,18.78792 -3.6652,15.09102 0.68052,43.09394 14.33245,48.82005 z" | ||
+ | style="fill:#66bdbe;fill-opacity:1;stroke:none;stroke-width:0.85845071px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" /> | ||
+ | <path | ||
+ | style="fill:#66bdbe;fill-opacity:1;stroke:none;stroke-width:0.85845071px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1" | ||
+ | d="m 403.97331,763.79067 c -2.92155,-15.39099 3.52969,-23.96699 12.06013,-32.9241 18.48489,-13.03844 39.78984,-6.82884 35.56362,16.1563 -4.75603,11.24235 1.05255,17.94281 1.33664,27.03309 -0.3782,13.05843 -3.44209,16.60024 -8.48369,19.25622 -8.01536,3.98807 -17.60638,10.55248 -25.17606,4.51448 -8.6647,-7.15764 -13.17111,-25.38795 -15.30064,-34.03599 z" | ||
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+ | sodipodi:nodetypes="ccccccc" /> | ||
+ | <path | ||
+ | sodipodi:nodetypes="cc" | ||
+ | inkscape:connector-curvature="0" | ||
+ | id="path4579" | ||
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+ | <path | ||
+ | style="fill:none;fill-opacity:1;stroke:#66bdbe;stroke-width:9.73361397;stroke-linecap:butt;stroke-linejoin:miter;stroke-miterlimit:4;stroke-dasharray:none;stroke-opacity:1" | ||
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+ | </g> | ||
+ | </g> | ||
+ | </svg> | ||
+ | </div> | ||
+ | <div id="box2" class="icon-box"> | ||
+ | <svg | ||
+ | width="100%" | ||
+ | height="auto" | ||
+ | viewBox="0 0 140 90" | ||
+ | version="1.1" | ||
+ | id="svg8182"> | ||
+ | <g | ||
+ | inkscape:label="Layer 1" | ||
+ | inkscape:groupmode="layer" | ||
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+ | <div class="col-lg-4 col-md-4 col-xs-12"> <h4 style="color: white !important; text-align: center;border: 2px solid white;cursor: pointer" id="general_abstract_button">General Abstract</h4></div> | ||
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+ | |||
+ | The concept of life turned out to be immensely powerful and rapidly transformed our planet into what ET could easily describe as a huge bioreactor. Innumerable rounds of mutation and selection over billions of years gave rise to the beautiful biological diversity and complexity we can appreciate today. Life appears to seamlessly adapt to even the most harsh and unfriendly environments by finding clever solutions – provided it has enough time to do so. And this is where our project begins. | ||
+ | |||
+ | This year, the iGEM team Heidelberg aims at harnessing the enormous power of Darwinian evolution to facilitate the development of biomolecules for human benefit. To this end, we will build upon the PACE (phage-assisted continuous evolution) method, which miniaturizes and accelerates evolution and governs it towards a predefined purpose. PACE couples the survival of quickly mutating phages carrying a scaffold protein to directed selection within E. coli hosts. Thereby, proteins with desired properties can be evolved within hours instead of centuries. To harness its enormous potential, we will create a comprehensive and standardized toolbox and accompanying software that will enable the application of PACE on diverse protein classes, including enzymes for pharmaceutical and biomaterial production.</p> | ||
+ | </div> | ||
+ | |||
+ | <div id="Protein Interaction" style="display: none;"> | ||
+ | |||
+ | <p style="color: white !important"> | ||
+ | |||
+ | The concept of life turned out to be immensely powerful and rapidly transformed our planet into what ET could easily describe as a huge bioreactor. Innumerable rounds of mutation and selection over billions of years gave rise to the beautiful biological diversity and complexity we can appreciate today. Life appears to seamlessly adapt to even the most harsh and unfriendly environments by finding clever solutions – provided it has enough time to do so. And this is where our project begins. | ||
+ | |||
+ | This year, the iGEM team Heidelberg aims at harnessing the enormous power of Darwinian evolution to facilitate the development of biomolecules for human benefit. To this end, we will build upon the PACE (phage-assisted continuous evolution) method, which miniaturizes and accelerates evolution and governs it towards a predefined purpose. PACE couples the survival of quickly mutating phages carrying a scaffold protein to directed selection within E. coli hosts. Thereby, proteins with desired properties can be evolved within hours instead of centuries. To harness its enormous potential, we will create a comprehensive and standardized toolbox and accompanying software that will enable the application of PACE on diverse protein classes, including enzymes for pharmaceutical and biomaterial production.</p> | ||
</div> | </div> | ||
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+ | |||
+ | The concept of life turned out to be immensely powerful and rapidly transformed our planet into what ET could easily describe as a huge bioreactor. Innumerable rounds of mutation and selection over billions of years gave rise to the beautiful biological diversity and complexity we can appreciate today. Life appears to seamlessly adapt to even the most harsh and unfriendly environments by finding clever solutions – provided it has enough time to do so. And this is where our project begins. | ||
+ | |||
+ | This year, the iGEM team Heidelberg aims at harnessing the enormous power of Darwinian evolution to facilitate the development of biomolecules for human benefit. To this end, we will build upon the PACE (phage-assisted continuous evolution) method, which miniaturizes and accelerates evolution and governs it towards a predefined purpose. PACE couples the survival of quickly mutating phages carrying a scaffold protein to directed selection within E. coli hosts. Thereby, proteins with desired properties can be evolved within hours instead of centuries. To harness its enormous potential, we will create a comprehensive and standardized toolbox and accompanying software that will enable the application of PACE on diverse protein classes, including enzymes for pharmaceutical and biomaterial production.</p> | ||
+ | </div> | ||
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+ | |||
+ | <p style="color: white !important"> | ||
+ | This year, the iGEM team Heidelberg aims at harnessing the enormous power of Darwinian evolution to facilitate the development of biomolecules for human benefit. To this end, we will build upon the PACE (phage-assisted continuous evolution) method, which miniaturizes and accelerates evolution and governs it towards a predefined purpose. PACE couples the survival of quickly mutating phages carrying a scaffold protein to directed selection within E. coli hosts. Thereby, proteins with desired properties can be evolved within hours instead of centuries. To harness its enormous potential, we will create a comprehensive and standardized toolbox and accompanying software that will enable the application of PACE on diverse protein classes, including enzymes for pharmaceutical and biomaterial production.</p> | ||
+ | </div> | ||
+ | <div id="Screening" style="display: none;"> | ||
+ | |||
+ | <p style="color: white !important">Abstract on protein Interaction About four billion years ago our planet was at a historic turning point. While organic chemistry had already been invented, the recent generation of organic molecules was profoundly different. They organized into spatially confined structures and self-replicated at an ever-increasing speed. Soon, the freely available organic building blocks became limited and the increasingly complex structures began to actively compete for resources and space. Life emerged and with it the Darwinian evolution. | ||
+ | |||
+ | The concept of life turned out to be immensely powerful and rapidly transformed our planet into what ET could easily describe as a huge bioreactor. Innumerable rounds of mutation and selection over billions of years gave rise to the beautiful biological diversity and complexity we can appreciate today. Life appears to seamlessly adapt to even the most harsh and unfriendly environments by finding clever solutions – provided it has enough time to do so. And this is where our project begins. | ||
+ | |||
+ | This year, the iGEM team Heidelberg aims at harnessing the enormous power of Darwinian evolution to facilitate the development of biomolecules for human benefit. To this end, we will build upon the PACE (phage-assisted continuous evolution) method, which miniaturizes and accelerates evolution and governs it towards a predefined purpose. PACE couples the survival of quickly mutating phages carrying a scaffold protein to directed selection within E. coli hosts. Thereby, proteins with desired properties can be evolved within hours instead of centuries. To harness its enormous potential, we will create a comprehensive and standardized toolbox and accompanying software that will enable the application of PACE on diverse protein classes, including enzymes for pharmaceutical and biomaterial production.he concept of life turned out to be immensely powerful and rapidly transformed our planet into what ET could easily describe as a huge bioreactor. Innumerable rounds of mutation and selection over billions of years gave rise to the beautiful biological diversity and complexity we can appreciate today. Life appears to seamlessly adapt to even the most harsh and unfriendly environments by finding clever solutions – provided it has enough time to do so. And this is where our project begins. | ||
+ | |||
+ | This year, the iGEM team Heidelberg aims at harnessing the enormous power of Darwinian evolution to facilitate the development of biomolecules for human benefit. To this end, we will build upon the PACE (phage-assisted continuous evolution) method, which miniaturizes and accelerates evolution and governs it towards a predefined purpose. PACE couples the survival of quickly mutating phages carrying a scaffold protein to directed selection within E. coli hosts. Thereby, proteins with desired properties can be evolved within hours instead of centuries. To harness its enormous potential, we will create a comprehensive and standardized toolbox and accompanying software that will enable the application of PACE on diverse protein classes, including enzymes for pharmaceutical and biomaterial production.</p> | ||
+ | </div> | ||
+ | <div id="Opto Genetics" style="display: none;"> | ||
+ | |||
+ | <p style="color: white !important">Abstract on protein Interaction About four billion years ago our planet was at a historic turning point. While organic chemistry had already been invented, the recent generation of organic molecules was profoundly different. They organized into spatially confined structures and self-replicated at an ever-increasing speed. Soon, the freely available organic building blocks became limited and the increasingly complex structures began to actively compete for resources and space. Life emerged and with it the Darwinian evolution. | ||
+ | |||
+ | The concept of life turned out to be immensely powerful and rapidly transformed our planet into what ET could easily describe as a huge bioreactor. Innumerable rounds of mutation and selection over billions of years gave rise to the beautiful biological diversity and complexity we can appreciate today. Life appears to seamlessly adapt to even the most harsh and unfriendly environments by finding clever solutions – provided it has enough time to do so. And this is where our project begins. | ||
+ | |||
+ | This year, the iGEM team Heidelberg aims at harnessing the enormous power of Darwinian evolution to facilitate the development of biomolecules for human benefit. To this end, we will build upon the PACE (phage-assisted continuous evolution) method, which miniaturizes and accelerates evolution and governs it towards a predefined purpose. PACE couples the survival of quickly mutating phages carrying a scaffold protein to directed selection within E. coli hosts. Thereby, proteins with desired properties can be evolved within hours instead of centuries. To harness its enormous potential, we will create a comprehensive and standardized toolbox and accompanying software that will enable the application of PACE on diverse protein classes, including enzymes for pharmaceutical and biomaterial production.</p> | ||
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<h4> Follow us on </h4> | <h4> Follow us on </h4> | ||
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Revision as of 13:29, 19 October 2017
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