Team:Heidelberg
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From 2014.igem.org
Life shows an astonishing diversity and complexity, resulting from millions of years of random mutation and selection.
Accelerate Evolutionto drive Innovation for human benefit
Explore our projectTo speed up and direct evolution, we use phage-assisted continuous evolution and our newly created & simple method called PREDCEL
Klick here for our second video!
No way to be fast enough without
ModelingLearn how we optimized our experimental parameters using ODE models calibrated with wet lab data.
And the best: Our interactive models run entirely in your browser!
Still too slow? Meet our Artificial Intelligence for Genetic Evolution Mimicking,
AiGEM!AiGEM comprises a deep neuronal network and accompanying genetic algorithm able to fast-forward directed evolution in silico
Not convinced yet? Check out our fully in silico evolved, optimized Beta-lactamase and reprogrammed Beta-glucuronidase!
To make a difference, we need to consider the whole
Colorful PictureOur integrated human practice activities helped us to make our technology safer and stimulate its responsible use, ideally to address urgent human needs.
Evolving novel cytochromes with help of in silico predicted riboswitches, to enable fully biological production of organosilicons. Using PREDCEL, we engineered the product specificity of cytochrome P450 1A2 towards theophylline.
Now it’s on you. Our toolbox guide and RFC help you to get started.
