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<section class="TrypIntro"> | <section class="TrypIntro"> | ||
<div class="Title"> | <div class="Title"> | ||
− | <h1>Affinity | + | <h1>Affinity Molecule library</h1> </div> |
<div class="Textbox Results-Desc"> | <div class="Textbox Results-Desc"> | ||
<!--Introduction--> | <!--Introduction--> | ||
+ | |||
+ | <div class="col-lg-4 banner-column" style="float: right;"> | ||
+ | <div class="figure-fullwidth"> | ||
+ | <div class="figure-center-imagebox.Banner-box"> | ||
+ | <img class="figure-center-img bnl_banner" src="https://static.igem.org/mediawiki/2017/5/54/T--Wageningen_UR--Application_Device_GPS.jpg" /> | ||
+ | </div> | ||
<p> | <p> | ||
− | + | The modularity and specificity of the Mantis diagnostic system comes from the use of affinity molecules. Affinity molecules are | |
− | + | antibody mimetics based on staphylococcal protein A (SPA) (Nord et al., 1997).The small, 6kDa, affinity proteins are based on the | |
− | + | Z domain of the cell-wall anchored bacterial protein A. The native function of protein A is immunoglobin binding and contributes | |
− | + | to evading the immune system (Nord et al., 1995). By making changes to 13 amino acids on 2 helices essential for specificity, | |
− | + | affibodies for a wide variety of targets can be developed (Figure X). Since its discovery affibodies have been developed for targets | |
− | + | such as insulin, fibrinogen, transferrin, tumor necrosis factor-a, IL-8, gp120, CD28, human serum albumin, IgA, IgE and HER2 | |
− | + | (Löfblom et al., 2010). Potential uses for these affibodies are imaging, purification, detection and many therapeutic applications | |
− | + | (Löfblom et al., 2010).</p> | |
</div></section> | </div></section> |
Revision as of 12:50, 23 October 2017
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