Brittneywick (Talk | contribs) |
Evan pepper (Talk | contribs) |
||
Line 504: | Line 504: | ||
<div class="row"> | <div class="row"> | ||
<div class="col-md-4"> | <div class="col-md-4"> | ||
− | <h3>Project Homepage</h3> | + | <h3><b>Project Homepage</b></h3> |
<hr> | <hr> | ||
<a href="https://2017.igem.org/Team:UCSC/Project" class="proj-button"> | <a href="https://2017.igem.org/Team:UCSC/Project" class="proj-button"> | ||
Line 515: | Line 515: | ||
<div class="col-md-8"> | <div class="col-md-8"> | ||
− | <h3>Click here to learn more!</h3> | + | <h3><b>Click here to learn more!</b></h3> |
<hr> | <hr> | ||
<div class="row"> | <div class="row"> | ||
<a href="https://2017.igem.org/Team:UCSC/B-12" class="proj-button"> | <a href="https://2017.igem.org/Team:UCSC/B-12" class="proj-button"> | ||
− | <img src="https://static.igem.org/mediawiki/2017/ | + | <img src="https://static.igem.org/mediawiki/2017/a/a2/B12_flask_button.png" class="proj-button-image"> |
<div class="proj-button-desc"> | <div class="proj-button-desc"> | ||
− | <div class="overlap-button-text"> | + | <div class="overlap-button-text">VITAMIN B<sub>12</sub></div> |
</div> | </div> | ||
</a> | </a> | ||
<a href="https://2017.igem.org/Team:UCSC/Model" class="proj-button"> | <a href="https://2017.igem.org/Team:UCSC/Model" class="proj-button"> | ||
− | <img src="https://static.igem.org/mediawiki/2017/ | + | <img src="https://static.igem.org/mediawiki/2017/b/be/Modeling_button.png" class="proj-button-image"> |
<div class="proj-button-desc"> | <div class="proj-button-desc"> | ||
− | <div class="overlap-button-text"> | + | <div class="overlap-button-text">MODELING</div> |
</div> | </div> | ||
</a> | </a> | ||
Line 535: | Line 535: | ||
<img src="https://static.igem.org/mediawiki/2017/e/e6/Results_icon.png" class="proj-button-image"> | <img src="https://static.igem.org/mediawiki/2017/e/e6/Results_icon.png" class="proj-button-image"> | ||
<div class="proj-button-desc"> | <div class="proj-button-desc"> | ||
− | <div class="overlap-button-text"> | + | <div class="overlap-button-text">RESULTS</div> |
</div> | </div> | ||
</a> | </a> | ||
Line 544: | Line 544: | ||
<img src="https://static.igem.org/mediawiki/2017/0/0b/Cyano_button_icon.png" class="proj-button-image"> | <img src="https://static.igem.org/mediawiki/2017/0/0b/Cyano_button_icon.png" class="proj-button-image"> | ||
<div class="proj-button-desc"> | <div class="proj-button-desc"> | ||
− | <div class="overlap-button-text"> | + | <div class="overlap-button-text">TARGET ORGANISM</div> |
</div> | </div> | ||
</a> | </a> | ||
Line 551: | Line 551: | ||
<img src="https://static.igem.org/mediawiki/2017/9/9c/Parts_icon.png" class="proj-button-image"> | <img src="https://static.igem.org/mediawiki/2017/9/9c/Parts_icon.png" class="proj-button-image"> | ||
<div class="proj-button-desc"> | <div class="proj-button-desc"> | ||
− | <div class="overlap-button-text"> | + | <div class="overlap-button-text">PARTS</div> |
</div> | </div> | ||
</a> | </a> |
Revision as of 22:37, 28 October 2017
Acetaminophen Metabolics
"Antipyretic drugs, by being analgesics, reduce not only the fever but also the pain."
We aim to genetically modify PCC 7942 to produce acetaminophen, a common mild anesthetic and antipyretic recognized by the WHO as an essential medicine [1]. However, in many countries with lower regulations and faulty policies regarding drug manufacturing, acetaminophen can be synthesized with lethal toxins that result in hundreds of deaths worldwide [23]. Acetaminophen is oftenused in conjunction with opioid pain medications postoperatively to enhance pain relief, thus reducing reliance upon opioid pharmaceuticals [24].
We are using a previously engineered pathway in E. coli as a model of acetaminophen biosynthesis to enhance PCC 7942 [26, 25]. The pathway converts chorismate, an abundant aminoacid precursor of tryptophan, phenylalanine, and tyrosine, into acetaminophen with the addition ofthe 4ABH gene from A. bisporus, an edible mushroom, and nhoA from E. coli.