Difference between revisions of "Team:Fudan/Applied Design"
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| + | <div class="block main-text main-text"> | ||
| + | <h class="highlight-title dark-blue"><center></br></br></br>Antigen density heterogeneity and limited treatment, </br>two obstacles in improving therapeutic effect and applicability of immunotherapy</center></h> | ||
| + | <h></h> | ||
| + | <h class="highlight-title dark-blue"></br></br>Target antigen density heterogeneity</h> | ||
| + | <p></br>The expression of the antigen on individual cells within a given tumor is different or heterogeneous. A solid tumor mass consists of numerous tumor cells. In thesetumor cells, some may express relatively less tumor antigens, others may express relatively more tumor antigens. Meanwhile, a given tumor antigen is not only expressed on malignant cells, but may also be expressed on normalcells at a low level <font color="dark-blue">(Figure 1A)</font>. Thus, normal cells expressing low level of tumor antigens subsequently should not be targeted, otherwise would casusecomplications. Carefully control the on-target/off-tumor effect is critical for the success of immunotherapy. <font color="dark-blue">(Figure 1B)</font> </br></br> | ||
| + | </p> | ||
| + | </div> | ||
Revision as of 14:25, 30 October 2017
The expression of the antigen on individual cells within a given tumor is different or heterogeneous. A solid tumor mass consists of numerous tumor cells. In thesetumor cells, some may express relatively less tumor antigens, others may express relatively more tumor antigens. Meanwhile, a given tumor antigen is not only expressed on malignant cells, but may also be expressed on normalcells at a low level (Figure 1A). Thus, normal cells expressing low level of tumor antigens subsequently should not be targeted, otherwise would casusecomplications. Carefully control the on-target/off-tumor effect is critical for the success of immunotherapy. (Figure 1B)
